Results 41 to 50 of about 283,019 (191)

Nude mice multi-drug resistance model of orthotopic transplantation of liver neoplasm and Tc-99m MIBI SPECT on p-glycoprotein

World Journal of Gastroenterology, 2005
To establish a model of drug-resistant neoplasms using a nude mice model, orthotopic transplantation of liver neoplasm and sporadic abdominal chemotherapy.Hepatocellular carcinoma cells HepG2 were cultured and injected subdermally to form the tumor-supplying mice.
Yu, Han, Xiao-Ping, Chen, Zhi-Yong, Huang, Hong, Zhu   +3 more
openaire   +2 more sources

Mitochondrion: Main organelle in orchestrating cancer escape from chemotherapy

Cancer Reports
Background Chemoresistance is a challenging barrier to cancer therapy, and in this context, the role of mitochondria is significant. We put emphasis on key biological characteristics of mitochondria, contributing to tumor escape from various therapies ...
Samaneh Mostafavi, Nahid Eskandari
doaj   +1 more source

Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms

Oncotarget, 2014
// Shih-Min A. Huang 1,2,* , Anlai Wang 1,* , Rita Greco 1 , Zhifang Li 1 , Fangxian Sun 1 , Claude Barberis 3 , Michel Tabart 4 , Vinod Patel 3 , Laurent Schio 4 , Raelene Hurley 1 , Bo Chen 5 , Hong Cheng 1 , Christoph Lengauer 1,6 , Jack Pollard 1 , James Watters 1 , Carlos Garcia-Echeverria 4 , Dmitri Wiederschain 1 , Francisco Adrian 1 and ...
Shih-Min A. Huang, Anlai Wang, Rita Greco, Zhifang Li, Fangxian Sun, Claude Barberis, Michel Tabart, Vinod Patel, Laurent Schio, Raelene Hurley, Bo Chen, Hong Cheng, Christoph Lengauer, Jack Pollard, James Watters, Carlos Garcia-Echeverria, Dmitri Wiederschain, Francisco Adrian, JingXin Zhang   +18 more
openaire   +2 more sources

Bortezomib resistance can be reversed by induced expression of plasma cell maturation markers in a mouse in vitro model of multiple myeloma.

PLoS ONE, 2013
Multiple myeloma (MM), the second most common hematopoietic malignancy, remains an incurable plasma cell (PC) neoplasm. While the proteasome inhibitor, bortezomib (Bz) has increased patient survival, resistance represents a major treatment obstacle as ...
Holly A F Stessman, Aatif Mansoor, Fenghuang Zhan, Michael A Linden, Brian Van Ness, Linda B Baughn   +5 more
doaj   +1 more source

RAB family gene expression in breast cancer cells under influence of paclitaxel [PDF]

, 2011
The aim of this study was to investigate the role of paclitaxel on RAB family of genes in primary breast cancer cell lines. The cancer breast cells obtained from 40 women during mastectomy were used to address this issue. The group included patients with
Andrzej Wilkolaski, Jolanta Rzymowska, Piotr Maj, Tadeusz Malewski   +3 more
core   +1 more source

Emerging targets in human lymphoma: targeting the MYD88 mutation [PDF]

, 2016
B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link ...
Horikawa, Keisuke, Jeelall, Yogesh S., Wang, James Q.   +2 more
core   +1 more source

The relationship of site to transplantability [PDF]

, 1963
Thesis (M.A.)--Boston ...
Anderson, Leonard L.
core  

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

Circular RNAs: key regulators of paclitaxel sensitivity and resistance in cancer

European Journal of Medical Research
Paclitaxel remains a cornerstone of cancer therapy, yet resistance significantly limits its clinical efficacy. Emerging evidence implicates circular RNAs (circRNAs) as key regulators of paclitaxel resistance, offering potential biomarkers and therapeutic
Zahra Tajik, Soudeh Ghafouri-Fard
doaj   +1 more source

Polyphenols and Chronic Myeloid Leukemia: Emerging Therapeutic Opportunities

Hemato
Background/Objectives: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the BCR–ABL fusion gene, whose constitutive tyrosine kinase activity drives leukemogenesis.
Claudia Moriello, Chiara De Rosa, Stefania D’Angelo, Perrone Pasquale   +3 more
doaj   +1 more source