Results 251 to 260 of about 505,639 (311)

HIV Treatment Paradigm Shifts over the Past 40 Years. [PDF]

Jugan Geongang Gwa Jilbyeong
Heo JY.
europepmc   +1 more source

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Disrupting resistance: novel therapeutic approaches to combat multidrug resistance in fusion-negative rhabdomyosarcoma. [PDF]

Cancer Drug Resist
Codenotti S, Marampon F, Megiorni F, Cattaneo CG, Gastaldello S, Pozzo E, Sampaolesi M, Rota R, Keller C, Fanzani A.   +9 more
europepmc   +1 more source

SUPER: Upcycling Genetic Parts for Precise Gene Expression Control, Leakage Minimization, and Genetic Circuit Stability

Advanced Science, EarlyView.
To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo, Dongwon Park, Woosub Shin, Jongmin Kim   +3 more
wiley   +1 more source

Prevalence of primary HIV-1 drug resistance among antiretroviral-naïve individuals in Togo in 2023: a national study. [PDF]

Front Public Health
Ouro-Medeli A, Togan RM, Serrano L, Butel C, Atoun R, Youa F, Ali-Edje K, Douffan M, Ehlan P, Tegueni K, Amenti R, Konou AA, Salou M, Ekouevi DK, Peeters M, Dagnra AC.   +15 more
europepmc   +1 more source

Reversion of Val(Ganciclovir)-Resistance-Associated Mutations in Two SOT Patients with Mismatched Serostatus for CMV (D+/R-). [PDF]

Viruses
Seminari E, Tebaldi A, Sangani A, Giordani P, Lilleri D, Paolucci S, Campanini G, Iskandar E, Baldanti F, Bruno R.   +9 more
europepmc   +1 more source

Resistance Analysis of Low-Level Virologic Rebound During HIV-1 Treatment With Lenacapavir and Broadly Neutralizing Antibodies Teropavimab and Zinlirvimab. [PDF]

J Infect Dis
Selzer L, Demirdjian S, Falkard B, Li J, Martin R, Collins SE, Eron J, VanderVeen LA, Callebaut C.   +8 more
europepmc   +1 more source

Impaired host shutoff is a fitness cost associated with baloxavir marboxil resistance mutations in influenza A virus PA/PA-X nuclease domain. [PDF]

PLoS Pathog
Case JR, Khaperskyy DA.
europepmc   +1 more source

Maturation inhibitors: a lost cause? [PDF]

EClinicalMedicine
Pozniak A.
europepmc   +1 more source