Results 271 to 280 of about 334,676 (308)
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Designing a low-cost drug resistance database for viral hepatitis
Antiviral Therapy, 2010Plans are outlined for a new database for hepatitis antiviral drug resistance mutations that will be closely linked to existing sequence databases. The new database will contain an infrastructure to store all available information on drug resistance mutations for the virus and a mutation can be searched by itself or in conjunction with the sequence ...
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Models of Viral Kinetics and Drug Resistance in HIV-1 Infection
AIDS Patient Care and STDs, 1998Mathematical models have become an increasingly valuable tool in HIV research. In particular, the mathematical analysis of drug-induced perturbations of the steady-state viral load in chronically infected patients has led to fundamental new insights into HIV dynamics in vivo and demonstrated that there is highly active viral replication throughout the ...
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A within-host drug resistance model with continuous state-dependent viral strains
Applied Mathematics Letters, 2020zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ting Guo, Zhipeng Qiu, Libin Rong
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Drugs, 1996
High rates of viral replication throughout HIV infection, and the frequency of mutation occurring during each replication cycle due to the inaccuracy of reverse transcriptase, drive the potential for drug-resistant viral variants to appear under the selective pressure of antiretroviral therapy.
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High rates of viral replication throughout HIV infection, and the frequency of mutation occurring during each replication cycle due to the inaccuracy of reverse transcriptase, drive the potential for drug-resistant viral variants to appear under the selective pressure of antiretroviral therapy.
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Mathematical Approaches in the Study of Viral Kinetics and Drug Resistance in HIV-1 Infection
Current Drug Target -Infectious Disorders, 2003We review some crucial aspects of drug therapy and viral resistance that have been investigated within the framework developed for the modelling of virus kinetics. First, we give a general overview on the use of mathematical models in the field of HIV research.
Müller V, Bonhoeffer S
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Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation
2016Viral proteases have been shown to be effective targets of anti-viral therapies for human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, under the pressure of therapy including protease inhibitors, the virus evolves to select drug resistance mutations both in the protease and substrates. In my thesis study, I aimed to understand the
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Efficiency of Drug Resistance Genotypic Tests in Specimens with Low HIV Viral Load
Antiviral Therapy, 1999The early recognition of resistance to antiretroviral agents could allow a rapid switch in therapy and therefore avoid the accumulation of mutations and reduce the risk of cross-resistance. However, the efficiency of genotypic tests in specimens with low viral load (VL) is severely compromised since human immunodeficiency virus (HIV) RNA in these ...
M, Gómez-Cano +6 more
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The mechanism for emergence of viral drug-resistance.
Nihon rinsho. Japanese journal of clinical medicine, 2019Antiviral drug was firstly reported regarding thiosemicarbazones developed for poxviruses in 1951. Then, human beings have been developed antiviral drugs using the latest technolo- gies including drug-design by computer, selection from huge compounds, antibodies and ge- nome editing.
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Drug-resistant Viral Hepatitis
Journal of Infection, 2000M, Wright, J, Main, H C, Thomas
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Expert Opinion on Investigational Drugs, 1997
Massive viral turnover and reverse transcriptase's high error rate create the potential for drug-resistant viral variants to appear rapidly under the selective pressure of antiretroviral therapy. Loss of antiviral effect in treatment-adherent persons is most commonly coincident with the appearance of viral mutants with reduced drug sensitivity.
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Massive viral turnover and reverse transcriptase's high error rate create the potential for drug-resistant viral variants to appear rapidly under the selective pressure of antiretroviral therapy. Loss of antiviral effect in treatment-adherent persons is most commonly coincident with the appearance of viral mutants with reduced drug sensitivity.
openaire +2 more sources