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The effect of transmitted HIV-1 drug resistance on pre-therapy viral load
AIDS, 2010Reduced replication capacity of viruses expressing drug resistant mutations implies that patients with transmitted drug resistance (TDR) could have lower HIV RNA viral load than those infected with wild-type virus.We performed analysis using data from the UK HIV Drug Resistance Database and the UK CHIC study.
Harrison, Linda +8 more
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The impact of the M184V substitution on drug resistance and viral fitness
Expert Review of Anti-infective Therapy, 2004Treatment of HIV/AIDS with antiretroviral therapy can result in HIV-1 drug resistance, limiting its use. Resistance mutations arise prior to therapy due to errors in HIV-1 replication, and are also spread by sexual and other modes of transmission. However, it is also generally believed that resistance is due to multiple drug mutations to any single or ...
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Efficiency of Drug Resistance Genotypic Tests in Specimens with Low HIV Viral Load
Antiviral Therapy, 1999The early recognition of resistance to antiretroviral agents could allow a rapid switch in therapy and therefore avoid the accumulation of mutations and reduce the risk of cross-resistance. However, the efficiency of genotypic tests in specimens with low viral load (VL) is severely compromised since human immunodeficiency virus (HIV) RNA in these ...
M, Gómez-Cano +6 more
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Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections
The Lancet Infectious Diseases, 2017Antibiotics have revolutionised medicine in many aspects, and their discovery is considered a turning point in human history. However, the most serious consequence of the use of antibiotics is the concomitant development of resistance against them. The marine environment has proven to be a very rich source of diverse natural products with significant ...
Abdelmohsen, Usama Ramadan +6 more
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Drugs, 1996
High rates of viral replication throughout HIV infection, and the frequency of mutation occurring during each replication cycle due to the inaccuracy of reverse transcriptase, drive the potential for drug-resistant viral variants to appear under the selective pressure of antiretroviral therapy.
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High rates of viral replication throughout HIV infection, and the frequency of mutation occurring during each replication cycle due to the inaccuracy of reverse transcriptase, drive the potential for drug-resistant viral variants to appear under the selective pressure of antiretroviral therapy.
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Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation
2016Viral proteases have been shown to be effective targets of anti-viral therapies for human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, under the pressure of therapy including protease inhibitors, the virus evolves to select drug resistance mutations both in the protease and substrates. In my thesis study, I aimed to understand the
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Drug-resistant Viral Hepatitis
Journal of Infection, 2000M, Wright, J, Main, H C, Thomas
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The mechanism for emergence of viral drug-resistance.
Nihon rinsho. Japanese journal of clinical medicine, 2019Antiviral drug was firstly reported regarding thiosemicarbazones developed for poxviruses in 1951. Then, human beings have been developed antiviral drugs using the latest technolo- gies including drug-design by computer, selection from huge compounds, antibodies and ge- nome editing.
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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