Results 241 to 250 of about 334,676 (308)

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Mutation-Tolerant Inhibition of HIV-1 Integrase Strand Transfer by Secondary Metabolites from the Endophytic Fungus <i>Alternaria alternata</i> PO4PR2. [PDF]

Microorganisms
Mashabela N, Naidu D, Oduro-Kwateng E, Mkhwanazi NP.   +3 more
europepmc   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Characteristics of Drug Resistance Mutations in a Korean HIV/AIDS Cohort, and Risk Factors for Resistance Acquisition in ART-Experienced Patients. [PDF]

Infect Chemother
Lee M, Kim SM, Kim JH, Park BY, Choi JY, Kim JH, Kim YK, Kim SI, Kim SW, Hur J, Kim Y, Choi HJ, Song JY, Jeong O, Go MJ, Ryou S, Kim HS, Jeong HW.   +17 more
europepmc   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

A cocktail of SARS-CoV-2 S stem helix domain and receptor binding domain human monoclonal antibodies prevents the emergence of viral escape mutants. [PDF]

Microbiol Spectr
Ma Y, Ye C, Piepenbrink MS, Mahmoud SH, Cupic A, Castro E, Jackson N, Bayoumi M, Padron AS, García-Sastre A, Ippolito GC, Walter MR, Kobie JJ, Martinez-Sobrido L.   +13 more
europepmc   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Efficacy of dolutegravir-based therapy in achieving virological suppression in PLHIV in low- and middle-income countries: real-world evidence from a large clinical cohort in Cameroon. [PDF]

BMC Infect Dis
Tadenfok C, Fokam J, Semengue ENJ, Mossiang L, Oyie S, Noumo P, Ngia J, Beloumou GA, Djupsa Ndjeyep SC, Nka AD, Chenwi Ambe C, Ka'e AC, Takou D, Ngwese DTA, Anim-Keng TT, Forgwei L, Kengne A, Yagai B, Elong Lobe E, Feukeng A, Awoh RA, Bissek AZ, Vouking M, Ndjolo A, Ndembi N, Perno CF, Kouanfack C, Nkenfou C.   +27 more
europepmc   +1 more source

Recurrent and novel evolutionary pathways drive in vitro HIV-1 lenacapavir resistance with diverse phenotypic consequences. [PDF]

Nat Commun
Orris LL, Siddiqui MA, Tang J, Bose R, Yamashita M.   +4 more
europepmc   +1 more source

Organoids: From Bench to Bedside Applications. [PDF]

MedComm (2020)
Li K, Cao R, Li M, Tian Z, Fan H, Hong B, Liu X.   +6 more
europepmc   +1 more source