Results 221 to 230 of about 332,502 (264)
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The impact of the M184V substitution on drug resistance and viral fitness
Expert Review of Anti-infective Therapy, 2004Treatment of HIV/AIDS with antiretroviral therapy can result in HIV-1 drug resistance, limiting its use. Resistance mutations arise prior to therapy due to errors in HIV-1 replication, and are also spread by sexual and other modes of transmission. However, it is also generally believed that resistance is due to multiple drug mutations to any single or ...
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Effects of drug resistance on viral load in patients failing antiretroviral therapy
Journal of Medical Virology, 2006Previous studies on patients who develop drug resistant HIV-1 variants have shown that continued use of failing regimens might provide clinical benefit. However, the effect of long-term exposure to drug resistant variants may lead to emergence of compensatory mutations that may jeopardize this effect.
Machouf, N. +6 more
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Viral quasispecies and the problem of vaccine-escape and drug-resistant mutants
1997Since a first version of this article on the relevance of quasispecies to viral disease control was published by one of us [1], an explosion of information on viral quasispecies has been gathered by several groups. For many viruses, extreme complexity at the population level has been documented by direct copying into cDNA of viral RNA extracted from ...
E, Domingo +8 more
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Designing a low-cost drug resistance database for viral hepatitis
Antiviral Therapy, 2010Plans are outlined for a new database for hepatitis antiviral drug resistance mutations that will be closely linked to existing sequence databases. The new database will contain an infrastructure to store all available information on drug resistance mutations for the virus and a mutation can be searched by itself or in conjunction with the sequence ...
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Models of Viral Kinetics and Drug Resistance in HIV-1 Infection
AIDS Patient Care and STDs, 1998Mathematical models have become an increasingly valuable tool in HIV research. In particular, the mathematical analysis of drug-induced perturbations of the steady-state viral load in chronically infected patients has led to fundamental new insights into HIV dynamics in vivo and demonstrated that there is highly active viral replication throughout the ...
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Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation
2016Viral proteases have been shown to be effective targets of anti-viral therapies for human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, under the pressure of therapy including protease inhibitors, the virus evolves to select drug resistance mutations both in the protease and substrates. In my thesis study, I aimed to understand the
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Drugs, 1996
High rates of viral replication throughout HIV infection, and the frequency of mutation occurring during each replication cycle due to the inaccuracy of reverse transcriptase, drive the potential for drug-resistant viral variants to appear under the selective pressure of antiretroviral therapy.
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High rates of viral replication throughout HIV infection, and the frequency of mutation occurring during each replication cycle due to the inaccuracy of reverse transcriptase, drive the potential for drug-resistant viral variants to appear under the selective pressure of antiretroviral therapy.
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The effect of transmitted HIV-1 drug resistance on pre-therapy viral load
AIDS, 2010Reduced replication capacity of viruses expressing drug resistant mutations implies that patients with transmitted drug resistance (TDR) could have lower HIV RNA viral load than those infected with wild-type virus.We performed analysis using data from the UK HIV Drug Resistance Database and the UK CHIC study.
Harrison, Linda +8 more
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Mathematical Approaches in the Study of Viral Kinetics and Drug Resistance in HIV-1 Infection
Current Drug Target -Infectious Disorders, 2003We review some crucial aspects of drug therapy and viral resistance that have been investigated within the framework developed for the modelling of virus kinetics. First, we give a general overview on the use of mathematical models in the field of HIV research.
Müller V, Bonhoeffer S
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The mechanism for emergence of viral drug-resistance.
Nihon rinsho. Japanese journal of clinical medicine, 2019Antiviral drug was firstly reported regarding thiosemicarbazones developed for poxviruses in 1951. Then, human beings have been developed antiviral drugs using the latest technolo- gies including drug-design by computer, selection from huge compounds, antibodies and ge- nome editing.
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