Results 201 to 210 of about 332,502 (264)

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Next-generation sequencing: Driving a paradigm shift from pathogen detection to systems-level analysis. [PDF]

Infect Med (Beijing)
Peng Y, Wang Y, Liu L, Liu Y, Yu Y, Sun R, Yu Z.   +6 more
europepmc   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research. [PDF]

Microb Biotechnol
Brüssow H.
europepmc   +1 more source

Pretreatment drug resistance profiles and transmission dynamics of HIV-1 among adults aged ≥50 in Hebei Province, China. [PDF]

Front Cell Infect Microbiol
Fan X, Liu M, An N, Bai G, Xu X, Meng M, Cui L, Li Q, Lu X.   +8 more
europepmc   +1 more source

Protein language model embeddings improve HIV drug resistance prediction: a comprehensive benchmark with attention-based interpretability. [PDF]

Bioinformatics
Farquhar H.
europepmc   +1 more source

The challenge of HTLV-1 therapeutics: lessons from anti-protease approaches. [PDF]

New Microbes New Infect
Ahmadi Ghezeldasht S, Miri R, Shamsian SK, Mosavat A, Rezaee SA.   +4 more
europepmc   +1 more source

Drugs against broad-spectrum of coronaviruses. [PDF]

Front Immunol
Huang S, Zhang X, Luo W, Yao Y, Hu J, Wang X, Xin H.   +6 more
europepmc   +1 more source