Results 211 to 220 of about 332,502 (264)

Genotypic antiretroviral drug resistance testing at low viral loads in the UK

HIV Medicine, 2008
BackgroundAntiretroviral drug resistance testing is recommended in HIV‐1 infected patients failing therapy in order to inform treatment selection. Although guidelines and test manufacturers recommend a viral load of at least 500–1000 HIV‐1 RNA copies/mL for genotypic resistance testing to be performed, prompt management of virological failure could ...
, P A Cane
exaly   +5 more sources

Drugs Resistance Against Viral Diseases

2021
Viruses can cause different types of infections including respiratory, skin, foodborne and sexually transmitted ones. Worldwide trades of food and food by products and international travelling have resulted in the transmission of various viruses from developing countries to the America and European region.
Atif Liaqat, Muhammad Farhan Jahangir Chughtai, Adnan Khaliq, Tariq Mehmood, Samreen Ahsan, Kanza Saeed, Syed Junaid Ur Rahman, Nimra Sameed, Shoaib Aziz, Rabia Iqba, Waqas Ahmad, Saeed Ur Rahman   +11 more
openaire   +1 more source

Microbial and viral drug resistance mechanisms

Trends in Microbiology, 2002
Microorganisms and viruses have developed numerous resistance mechanisms that enable them to evade the effect of antimicrobials and antivirals. As a result, many have become resistant to almost every available means of treatment. This problem, although not new, is becoming increasingly acute and it is now clear that a fundamental understanding of the ...
Kenneth S, McKeegan, M Ines, Borges-Walmsley, Adrian R, Walmsley   +2 more
openaire   +2 more sources

Contingency and Entrenchment of Drug-Resistance Mutations in HIV Viral Proteins

The Journal of Physical Chemistry B, 2022
The ability of HIV-1 to rapidly mutate leads to antiretroviral therapy (ART) failure among infected patients. Drug-resistance mutations (DRMs), which cause a fitness penalty to intrinsic viral fitness, are compensated by accessory mutations with favorable epistatic interactions which cause an evolutionary trapping effect, but the kinetics of this ...
Indrani Choudhuri, Avik Biswas, Allan Haldane, Ronald M. Levy   +3 more
openaire   +2 more sources

Viral Drug Resistance and Fitness

2008
Publisher Summary This chapter presents recent findings related to human immunodeficiency virus (HIV)‐1 drug resistance and fitness. Antiretroviral therapy is a form of extrinsic pressure applied against the HIV‐1 that reduces replication but also selects for variants with reduced sensitivity to this pressure.
Miguel E, Quiñones-Mateu, Dawn M, Moore-Dudley, Oyebisi, Jegede, Jan, Weber, Eric, J Arts   +4 more
openaire   +2 more sources

The intersection between viral oncolysis, drug resistance, and autophagy

Biological Chemistry, 2015
Abstract Resistance to both cytotoxic and targeted therapies is a major problem facing cancer treatment. The mechanisms of resistance to unrelated drugs share many common features, including up-regulation of detoxifying pathways, activation of pro-survival mechanisms, and ineffective induction of cell death.
Beljanski, Vladimir, Chiang, Cindy, Hiscott, John   +2 more
openaire   +3 more sources

HIV drug resistance and viral fitness

2000
Publisher Summary The first documented cases of HIV drug resistance concerned AZT (zidovudine), a nucleoside analog that inhibits HIV replication by virtue of its activity, as a DNA chain terminator. Several mutations in the viral reverse transcriptase (RT), the enzyme that transcribes virion RNA into DNA in the newly infected cell, were identified ...
F, Clavel, E, Race, F, Mammano
openaire   +2 more sources