Results 261 to 270 of about 505,639 (311)
Some of the next articles are maybe not open access.
Drugs Resistance Against Viral Diseases
2021Viruses can cause different types of infections including respiratory, skin, foodborne and sexually transmitted ones. Worldwide trades of food and food by products and international travelling have resulted in the transmission of various viruses from developing countries to the America and European region.
Atif Liaqat +11 more
openaire +1 more source
Contingency and Entrenchment of Drug-Resistance Mutations in HIV Viral Proteins
The Journal of Physical Chemistry B, 2022The ability of HIV-1 to rapidly mutate leads to antiretroviral therapy (ART) failure among infected patients. Drug-resistance mutations (DRMs), which cause a fitness penalty to intrinsic viral fitness, are compensated by accessory mutations with favorable epistatic interactions which cause an evolutionary trapping effect, but the kinetics of this ...
Indrani Choudhuri +3 more
openaire +2 more sources
Microbial and viral drug resistance mechanisms
Trends in Microbiology, 2002Microorganisms and viruses have developed numerous resistance mechanisms that enable them to evade the effect of antimicrobials and antivirals. As a result, many have become resistant to almost every available means of treatment. This problem, although not new, is becoming increasingly acute and it is now clear that a fundamental understanding of the ...
Kenneth S, McKeegan +2 more
openaire +2 more sources
Viral Drug Resistance and Fitness
2008Publisher Summary This chapter presents recent findings related to human immunodeficiency virus (HIV)‐1 drug resistance and fitness. Antiretroviral therapy is a form of extrinsic pressure applied against the HIV‐1 that reduces replication but also selects for variants with reduced sensitivity to this pressure.
Miguel E, Quiñones-Mateu +4 more
openaire +2 more sources
The intersection between viral oncolysis, drug resistance, and autophagy
Biological Chemistry, 2015Abstract Resistance to both cytotoxic and targeted therapies is a major problem facing cancer treatment. The mechanisms of resistance to unrelated drugs share many common features, including up-regulation of detoxifying pathways, activation of pro-survival mechanisms, and ineffective induction of cell death.
Beljanski, Vladimir +2 more
openaire +3 more sources
HIV drug resistance and viral fitness
2000Publisher Summary The first documented cases of HIV drug resistance concerned AZT (zidovudine), a nucleoside analog that inhibits HIV replication by virtue of its activity, as a DNA chain terminator. Several mutations in the viral reverse transcriptase (RT), the enzyme that transcribes virion RNA into DNA in the newly infected cell, were identified ...
F, Clavel, E, Race, F, Mammano
openaire +2 more sources
Designing a low-cost drug resistance database for viral hepatitis
Antiviral Therapy, 2010Plans are outlined for a new database for hepatitis antiviral drug resistance mutations that will be closely linked to existing sequence databases. The new database will contain an infrastructure to store all available information on drug resistance mutations for the virus and a mutation can be searched by itself or in conjunction with the sequence ...
openaire +2 more sources
Surveillance of Multi Drug Resistant Bacteria Isolated from Virally Infected Broilers
International Journal of Veterinary Science, 2022One health call to ensure human, animal and environment safety put on a major responsibility on the animal health care sector starting with identifying the circulating pathogens and its multi drug resistant (MDR) patterns. This study was conducted on total 283 diseased broilers collected from small broilers flocks in Giza and El-Kalubia province, Egypt.
openaire +1 more source