Drug resistance outcomes of long-term ART with tenofovir disoproxil fumarate in the absence of virological monitoring [PDF]
, 2018 Objectives: The resistance profiles of patients receiving long-term ART in sub-Saharan Africa have been poorly described. This study obtained a sensitive assessment of the resistance patterns associated with long-term tenofovir-based ART in a ...
Appiah, Lambert T +9 more
core +3 more sources
Viruses, 2018 Emergence of human immunodeficiency virus type 1 (HIV-1) drug resistance arises from mutation fixation in the viral genome during antiretroviral therapy. Primary mutations directly confer antiviral drug resistance, while secondary mutations arise that do
José O. Maldonado, Louis M. Mansky
doaj +1 more source
Evolution of Drug-Resistant Viral Populations during Interruption of Antiretroviral Therapy [PDF]
Journal of Virology, 2011 ABSTRACTAnalysis of a large number of HIV-1 genomes at multiple time points after antiretroviral treatment (ART) interruption allows determination of the evolution of drug-resistant viruses and viral fitnessin vivoin the absence of drug selection pressure.
Dongning, Wang +7 more
openaire +2 more sources
AIDS Research and Therapy, 2009 Access to antiretroviral therapy (ART) is increasing in resource-limited settings (RLS) and can successfully reduce HIV-related morbidity and mortality.
Reynaerts Jacqueline +8 more
doaj +1 more source
In Vivo validation of a bioinformatics based tool to identify reduced replication capacity in HIV-1. [PDF]
, 2010 Although antiretroviral drug resistance is common in treated HIV infected individuals, it is not a consistent indicator of HIV morbidity and mortality.
Kitchen, Christina MR +2 more
core +2 more sources
Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus [PDF]
The Journal of Infectious Diseases, 2003 Certain mutations in the viral DNA polymerase (pol) gene are known to confer drug resistance when transferred to susceptible human cytomegalovirus (CMV) strains, whereas other putative resistance mutations remain unproven. A new marker-transfer technique was used to produce recombinant CMV strains, to determine the drug susceptibility phenotypes ...
Sunwen, Chou +4 more
openaire +2 more sources
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. [PDF]
, 2007 BackgroundWe reported previously on the emergence and clinical implications of simian immunodeficiency virus (SIVmac251) mutants with a K65R mutation in reverse transcriptase (RT), and the role of CD8+ cell-mediated immune responses in suppressing ...
Bischofberger, Norbert +10 more
core +3 more sources
Personalizing HIV therapy, mission impossible? [PDF]
, 2012 Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core +1 more source
Pressurized DNA state inside herpes capsids-A novel antiviral target.
PLoS Pathogens, 2020 Drug resistance in viruses represents one of the major challenges of healthcare. As part of an effort to provide a treatment that avoids the possibility of drug resistance, we discovered a novel mechanism of action (MOA) and specific compounds to treat ...
Alberto Brandariz-Nuñez +2 more
doaj +1 more source
Identification of drug resistance mutations in HIV from constraints on natural evolution [PDF]
, 2015 Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape.
Barton, John P. +3 more
core +2 more sources