Results 31 to 40 of about 334,676 (308)

Access to art, adherence and drug resistance among HIV-Positive patients in rural Tanzania [PDF]

, 2015
HIV is one of the worst pandemics in recent times, having affected more than 70 million and with a mortality rate close to 50%. Antiretroviral drugs fight viral replication and has improved life of HIV infected patients since it was introduced.
Nyogea, Daniel, Nyogea, Daniel Simon
core   +1 more source

Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya

AIDS Research and Therapy, 2009
Access to antiretroviral therapy (ART) is increasing in resource-limited settings (RLS) and can successfully reduce HIV-related morbidity and mortality.
Reynaerts Jacqueline, Dauwe Kenny, Luchters Stanley, Steegen Kim, Mandaliya Kishor, Jaoko Walter, Plum Jean, Temmerman Marleen, Verhofstede Chris   +8 more
doaj   +1 more source

Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Machleidt, Werner, Hoffmann, D., Assfalg-Machleidt, Irmgard, Helm, K. von der, Nitschko, H., Koszinowski, U.   +5 more
core   +1 more source

Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients

Retrovirology, 2012
Background The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, and therefore are expected to ...
Theys Kristof, Deforche Koen, Vercauteren Jurgen, Libin Pieter, van de Vijver David AMC, Albert Jan, Åsjö Birgitta, Balotta Claudia, Bruckova Marie, Camacho Ricardo J, Clotet Bonaventura, Coughlan Suzie, Grossman Zehava, Hamouda Osamah, Horban Andrzei, Korn Klaus, Kostrikis Leondios G, Kücherer Claudia, Nielsen Claus, Paraskevis Dimitrios, Poljak Mario, Puchhammer-Stockl Elisabeth, Riva Chiara, Ruiz Lidia, Liitsola Kirsi, Schmit Jean-Claude, Schuurman Rob, Sönnerborg Anders, Stanekova Danica, Stanojevic Maja, Struck Daniel, Van Laethem Kristel, Wensing Annemarie MJ, Boucher Charles AB, Vandamme Anne-Mieke   +34 more
doaj   +1 more source

Drug resistance with monitored adherence [PDF]

, 2013
Drug resistance can be defined as the failure of a drug to exert its expected effect on pharmacological biomarkers and is caused by pharmacogenetic, cellular or clinical factors.
Walter, Philipp Niklaus
core   +1 more source

Pressurized DNA state inside herpes capsids-A novel antiviral target.

PLoS Pathogens, 2020
Drug resistance in viruses represents one of the major challenges of healthcare. As part of an effort to provide a treatment that avoids the possibility of drug resistance, we discovered a novel mechanism of action (MOA) and specific compounds to treat ...
Alberto Brandariz-Nuñez, Scott J Robinson, Alex Evilevitch   +2 more
doaj   +1 more source

Protease mediated maturation of HIV: Inhibitors of protease and the maturation process [PDF]

, 2012
Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol ...
Catherine S. Adamson, Adamson, Catherine S   +1 more
core   +1 more source

Future of Antiretroviral Drugs and Evolution of HIV-1 Drug Resistance

Viruses, 2023
Highly active antiretroviral (ARV) therapy has been used for many years, but the use in low- and middle-income countries of antiretroviral drugs with low genetic barrier to resistance, combined with limited availability of viral load testing, has led to ...
Charlotte Charpentier, Quentin Le Hingrat, Valentine Marie Ferré, Florence Damond, Diane Descamps   +4 more
doaj   +1 more source

Using small molecules to overcome drug resistance induced by a viral oncogene [PDF]

Cancer Cell, 2006
We used small molecule screening to discover compounds and mechanisms for overcoming E6 oncogene-mediated drug resistance. Using high-throughput screening in isogenic cell lines, we identified compounds that potentiate doxorubicin's lethality in E6-expressing colon cancer cells.
Smukste, Inese, Bhalala, Oneil, Persico, Marco, Stockwell, Brent R.   +3 more
openaire   +2 more sources

HIV-1C proviral DNA for detection of drug resistance mutations. [PDF]

PLoS ONE, 2018
BACKGROUND:Using HIV proviral DNA as a template may be suitable for initial detection of transmitted drug resistance mutations (TDRMs) as it is easy to handle and less expensive compared to RNA.
Kahsay Huruy, Andargachew Mulu, Uwe Gerd Liebert, Melanie Maier   +3 more
doaj   +1 more source