Results 31 to 40 of about 507,510 (307)

Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance [PDF]

AIDS and Behavior, 2017
Patient-initiated repackaging of antiretroviral therapy (ART) refers to removal of ART medications from their original manufacturer's containers, and putting them into alternative containers. This behavior may be triggered by stigma associated with HIV infection, and may impact patient outcomes.
Habib O, Ramadhani, Charles, Muiruri, Venance P, Maro, Balthazar, Nyombi, Michael, Omondi, Julian B, Mushi, Eileen S, Lirhunde, John A, Bartlett   +7 more
openaire   +2 more sources

HIV-1C proviral DNA for detection of drug resistance mutations. [PDF]

PLoS ONE, 2018
BACKGROUND:Using HIV proviral DNA as a template may be suitable for initial detection of transmitted drug resistance mutations (TDRMs) as it is easy to handle and less expensive compared to RNA.
Kahsay Huruy, Andargachew Mulu, Uwe Gerd Liebert, Melanie Maier   +3 more
doaj   +1 more source

Challenges and Opportunities for the Implementation of Virological Testing in resource-limited settings [PDF]

, 2012
Though the advantages of routine virological monitoring for patients on anti-retroviral therapy have been established, cost and complexity limit its full implementation.
Bartlett, Department of Health and Human Services, Emmanuel Fajardo, Hamers, Hamers, Helen Bygrave, Jani, Kerschberger, Laurent, Murtagh, Médecins Sans Frontières, Médecins Sans Frontières, Nathan Ford, Orrell, Orrell, Orrell, Oyomopito, Teri Roberts, UNAIDS, Médecins Sans Frontières, World Health Organization, World Health Organization, World Health Organization, World Health Organization, UNAIDS   +22 more
core   +3 more sources

Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting. [PDF]

, 2011
In resource-limited settings, many patients, with no prior protease inhibitor (PI) treatment on a second-line, high genetic barrier, ritonavir-boosted PI-containing regimen have virologic ...
Arribas, Bangsberg, Barreiro, Berg, Carolina Malavazzi, Cassani, Delaugerre, El-Khatib, Eric Decloedt, Frost, Gandhi, Gardner, Gary Maartens, Gathe, Gert Uves van Zyl, Helen McIlleron, Huang, Jean B Nachega, Kosuge, Lize van der Merwe, Michele Zeier, Mo, Monica Gandhi, Peter Smith, Pujades-Rodriguez, Quiros-Roldan, Riddler, Thijs E van Mens, van Zyl, van Zyl, Yong Huang   +30 more
core   +3 more sources

Modeling long-term longitudinal HIV dynamics with application to an AIDS clinical study

, 2009
A virologic marker, the number of HIV RNA copies or viral load, is currently used to evaluate antiretroviral (ARV) therapies in AIDS clinical trials. This marker can be used to assess the ARV potency of therapies, but is easily affected by drug exposures,
Huang, Yangxin, Lu, Tao
core   +1 more source

An expert consensus for the management of chronic hepatitis B in Asian Americans. [PDF]

, 2018
BACKGROUND: Hepatitis B virus (HBV) infection is common with major clinical consequences. In Asian Americans, the HBsAg carrier rate ranges from 2% to 16% which approximates the rates from their countries of origin.
Abbas, Abbas, Ahn, Beasley, Beasley, Bisceglie, Bogr, Brown, Buti, Centers for Disease Control, Chae, Chan, Chang, Chang, Chang, Chang, Chang, Chao, Chaung, Chen, Chen, Chen, Chen, Chi, Chien, Choe, Chu, Clemente, Della Corte, European Association for the Study of the Liver, Evans, Fang, Fattovich, Fontana, Fung, Gish, Hadziyannis, Halperin, Hann, Heathcote, Hongthanakorn, Hoofnagle, Hu, Huang, Hung, Hyun, Iino, Iloeje, Jeng, Keeffe, Kim, Komatsu, Konstantinou, Kowdley, Kuo, Kwong, Lai, Lai, Lai, Lai, Lampertico, Lau, Lau, Lee, Lee, Liang, Liaw, Liaw, Liaw, Liew, Lin, Lin, Lin, Liu, Liu, Liu, Lok, Lok, Lok, Loomba, MacLachlan, Manegold, Marcellin, Marcellin, Marcellin, Marcellin, Marcellin, Marcellin, Martin, Martin-Carbonero, Mast, McClune, McMahon, Mitchell, Monte, Murata, Mutimer, Nafa, Nguyen, Nguyen, Nikolopoulos, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Papatheodoridis, Park, Park, Park, Patterson, Perrillo, Perrillo, Pollack, Prati, Qiu, Reijnders, Sarin, Seto, Seto, Sherman, Shim, Shiraki, Sinatra, Sinn, Soriano, Stevens, Takano, Takayama, Takkenberg, Terrault, Thibault, Thio, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tse, Wang, Wedemeyer, Wei, Wen, Wiseman, Wursthorn, Xie, Xu, Yi, Yi, Yu, Yu, Yuen, Yuen, Yuen, Yuen, Yuen, Zhang, Zhang, Zhang, Zou   +173 more
core   +2 more sources

The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility. [PDF]

, 2016
BackgroundThe p6 region of the HIV-1 structural precursor polyprotein, Gag, contains two motifs, P7TAP11 and L35YPLXSL41, designated as late (L) domain-1 and -2, respectively.
Anastos, Kathryn, Burger, Harold, Carter, Carol A, Chen, Benjamin K, Chen, Chaoping, Durham, Natasha D, Foley, Brian, Kemal, Kimdar Sherefa, Kemp, Brittney R, Li, Hongru, Machihara, Satoshi, Shi, Binshan, Simon, Viviana, Watanabe, Susan M, Weiser, Barbara   +14 more
core   +1 more source

Using small molecules to overcome drug resistance induced by a viral oncogene [PDF]

Cancer Cell, 2006
We used small molecule screening to discover compounds and mechanisms for overcoming E6 oncogene-mediated drug resistance. Using high-throughput screening in isogenic cell lines, we identified compounds that potentiate doxorubicin's lethality in E6-expressing colon cancer cells.
Smukste, Inese, Bhalala, Oneil, Persico, Marco, Stockwell, Brent R.   +3 more
openaire   +2 more sources

HIV drug resistance and its associated factors among patients during interruption of antiretroviral therapy in China

Frontiers in Microbiology
BackgroundThe prevalence of human immunodeficiency virus (HIV) drug resistance among people living with HIV (PLWH) who experience treatment interruptions is a significant concern.
Zhongbao Zuo, Wei Huang, Lei Liu, Miaomiao Li, Hongli Chen, Yi Feng, Lingjie Liao, Yiming Shao, Yuhua Ruan, Jing Wu, Hui Xing   +10 more
doaj   +1 more source

Estimating HIV-1 fitness characteristics from cross-sectional genotype data.

PLoS Computational Biology, 2014
Despite the success of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV)-1 infection, virological failure due to drug resistance development remains a major challenge.
Sathej Gopalakrishnan, Hesam Montazeri, Stephan Menz, Niko Beerenwinkel, Wilhelm Huisinga   +4 more
doaj   +1 more source