Results 21 to 30 of about 332,502 (264)
HIV-1C proviral DNA for detection of drug resistance mutations. [PDF]
PLoS ONE, 2018 BACKGROUND:Using HIV proviral DNA as a template may be suitable for initial detection of transmitted drug resistance mutations (TDRMs) as it is easy to handle and less expensive compared to RNA.
Kahsay Huruy +3 more
doaj +1 more source
Frontiers in MicrobiologyBackgroundThe prevalence of human immunodeficiency virus (HIV) drug resistance among people living with HIV (PLWH) who experience treatment interruptions is a significant concern.
Zhongbao Zuo +10 more
doaj +1 more source
Estimating HIV-1 fitness characteristics from cross-sectional genotype data.
PLoS Computational Biology, 2014 Despite the success of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV)-1 infection, virological failure due to drug resistance development remains a major challenge.
Sathej Gopalakrishnan +4 more
doaj +1 more source
Low Incidence of HIV-1C Acquired Drug Resistance 10 Years after Roll-Out of Antiretroviral Therapy in Ethiopia: A Prospective Cohort Study. [PDF]
PLoS ONE, 2015 The emergence of HIV-1 drug resistance mutations has mainly been linked to the duration and composition of antiretroviral treatment (ART), as well as the level of adherence.
Andargachew Mulu +2 more
doaj +1 more source
Evolution of Drug-Resistant Viral Populations during Interruption of Antiretroviral Therapy [PDF]
Journal of Virology, 2011 ABSTRACTAnalysis of a large number of HIV-1 genomes at multiple time points after antiretroviral treatment (ART) interruption allows determination of the evolution of drug-resistant viruses and viral fitnessin vivoin the absence of drug selection pressure.
Dongning, Wang +7 more
openaire +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Using small molecules to overcome drug resistance induced by a viral oncogene [PDF]
Cancer Cell, 2006 We used small molecule screening to discover compounds and mechanisms for overcoming E6 oncogene-mediated drug resistance. Using high-throughput screening in isogenic cell lines, we identified compounds that potentiate doxorubicin's lethality in E6-expressing colon cancer cells.
Smukste, Inese +3 more
openaire +2 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Dominant drug targets suppress the emergence of antiviral resistance
eLife, 2014 The emergence of drug resistance can defeat the successful treatment of pathogens that display high mutation rates, as exemplified by RNA viruses.
Elizabeth J Tanner +5 more
doaj +1 more source
Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus [PDF]
The Journal of Infectious Diseases, 2003 Certain mutations in the viral DNA polymerase (pol) gene are known to confer drug resistance when transferred to susceptible human cytomegalovirus (CMV) strains, whereas other putative resistance mutations remain unproven. A new marker-transfer technique was used to produce recombinant CMV strains, to determine the drug susceptibility phenotypes ...
Sunwen, Chou +4 more
openaire +2 more sources