Results 41 to 50 of about 334,676 (308)

Evolution of Drug-Resistant Viral Populations during Interruption of Antiretroviral Therapy [PDF]

Journal of Virology, 2011
ABSTRACTAnalysis of a large number of HIV-1 genomes at multiple time points after antiretroviral treatment (ART) interruption allows determination of the evolution of drug-resistant viruses and viral fitnessin vivoin the absence of drug selection pressure.
Dongning, Wang, Charles B, Hicks, Neela D, Goswami, Emi, Tafoya, Ruy M, Ribeiro, Fangping, Cai, Alan S, Perelson, Feng, Gao   +7 more
openaire   +2 more sources

Viral DNA Polymerase Mutations Associated with Drug Resistance in Human Cytomegalovirus [PDF]

The Journal of Infectious Diseases, 2003
Certain mutations in the viral DNA polymerase (pol) gene are known to confer drug resistance when transferred to susceptible human cytomegalovirus (CMV) strains, whereas other putative resistance mutations remain unproven. A new marker-transfer technique was used to produce recombinant CMV strains, to determine the drug susceptibility phenotypes ...
Sunwen, Chou, Nell S, Lurain, Kenneth D, Thompson, Richard C, Miner, W Lawrence, Drew   +4 more
openaire   +2 more sources

Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 338)

AIDS Research and Therapy, 2007
Background The association between baseline drug resistance mutations and subsequent increase in viral failure has not been established for HIV-infected children.
McIntosh Kenneth, Yogev Ram, Mofenson Lynne M, Wiznia Andrew A, Hu Chengcheng, Petch Leslie A, Kovacs Andrea, Fiscus Susan A, Pelton Stephen I, Napravnik Sonia, Stanley Kenneth, Nachman Sharon A   +11 more
doaj   +1 more source

Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study [PDF]

, 2013
BACKGROUND: Non-adherence is one of the strongest predictors of therapeutic failure in HIV-positive patients. Virologic failure with subsequent emergence of resistance reduces future treatment options and long-term clinical success. METHODS: Prospective
Jürg Böni (36157), Yerly, Sabine, von Wyl Viktor, Alexandra Calmy (36005), Dunja Nicca (336117), Glass, Tracy R, Swiss HIV Cohort Study,, Hansjakob Furrer (93994), Günthard Huldrych F., Vincent Aubert (297526), Jürg Böni, Aubert Vincent, Calmy, Alexandra, Bucher, Heiner C, Huldrych F. Günthard (173082), Böni, J., Cavassini Matthias, Viktor von Wyl, Swiss HIV Cohort Study, Günthard, Huldrych F., Enos Bernasconi (174329), Furrer, Hansjakob, Heiner C Bucher, Klimkait, Thomas, Hansjakob Furrer, Alexandra Calmy, Calmy Alexandra, Aubert, Vincent, Glass, T.R., Sabine Yerly (82534), Dunja Nicca, Yerly, S., Bucher, Heiner C., Tracy R. Glass (134725), Yerly Ferrillo, Sabine, Bucher Heiner C., Tracy R Glass, Nicca, D., Bernasconi, E., Wainberg, Mark, Thomas Klimkait (178911), Calmy, A., Günthard, Huldrych F, Enos Bernasconi, Heiner C. Bucher (134728), Cavassini, M., Matthias Cavassini (146654), Aubert, V., Glass, Tracy R., Böni, Jürg, Klimkait Thomas, Thomas Klimkait, Glass Tracy R., Bernasconi, Enos, Nicca Dunja, von Wyl, Viktor, Nicca, Dunja, von Wyl, V., Furrer Hansjakob, Bernasconi Enos, Sabine Yerly, Furrer, H., Viktor von Wyl (146506), Günthard, H.F., Böni Jürg, Klimkait, T., Yerly Sabine, Vincent Aubert, Bucher, H.C., Huldrych F Günthard, Cavassini, Matthias, Matthias Cavassini   +71 more
core   +1 more source

Prevalence of and Viral Outcomes Associated with Primary HIV-1 Drug Resistance [PDF]

The Open AIDS Journal, 2012
Primary, or transmitted, HIV antiretroviral resistance is an ongoing concern despite continuing development of new antiretroviral therapies. We examined HIV surveillance data, including both patient demographic characteristics and laboratory data, combined with HIV genotypic test results to evaluate the comprehensiveness of drug resistance surveillance,
Buskin, SE, Zhang, S, Thibault, CS
openaire   +2 more sources

HIV drug resistance and its associated factors among patients during interruption of antiretroviral therapy in China

Frontiers in Microbiology
BackgroundThe prevalence of human immunodeficiency virus (HIV) drug resistance among people living with HIV (PLWH) who experience treatment interruptions is a significant concern.
Zhongbao Zuo, Wei Huang, Lei Liu, Miaomiao Li, Hongli Chen, Yi Feng, Lingjie Liao, Yiming Shao, Yuhua Ruan, Jing Wu, Hui Xing   +10 more
doaj   +1 more source

Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance [PDF]

AIDS and Behavior, 2017
Patient-initiated repackaging of antiretroviral therapy (ART) refers to removal of ART medications from their original manufacturer's containers, and putting them into alternative containers. This behavior may be triggered by stigma associated with HIV infection, and may impact patient outcomes.
Habib O, Ramadhani, Charles, Muiruri, Venance P, Maro, Balthazar, Nyombi, Michael, Omondi, Julian B, Mushi, Eileen S, Lirhunde, John A, Bartlett   +7 more
openaire   +2 more sources

Modelling the impact of antiretroviral use in resource-poor settings. [PDF]

, 2006
BACKGROUND: The anticipated scale-up of antiretroviral therapy (ART) in high-prevalence, resource-constrained settings requires operational research to guide policy on the design of treatment programmes.
Garnett, Geoff P, Baggaley Rebecca F, Geoff P Garnett, Neil M Ferguson, Ferguson Neil M, Baggaley, Rebecca F, Rebecca F Baggaley, Garnett Geoff P, Ferguson, Neil M   +8 more
core   +1 more source

Estimating HIV-1 fitness characteristics from cross-sectional genotype data.

PLoS Computational Biology, 2014
Despite the success of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV)-1 infection, virological failure due to drug resistance development remains a major challenge.
Sathej Gopalakrishnan, Hesam Montazeri, Stephan Menz, Niko Beerenwinkel, Wilhelm Huisinga   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source