Results 11 to 20 of about 332,502 (264)

Improving Viral Protease Inhibitors to Counter Drug Resistance [PDF]

Trends in Microbiology, 2016
Drug resistance is a major problem in health care, undermining therapy outcomes and necessitating novel approaches to drug design. Extensive studies on resistance to viral protease inhibitors, particularly those of HIV-1 and hepatitis C virus (HCV) protease, revealed a plethora of information on the structural and molecular mechanisms underlying ...
Yilmaz, Nese Kurt, Swanstrom, Ronald I., Schiffer, Celia A.   +2 more
openaire   +3 more sources

Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs

Molecules, 2019
HIV protease inhibitors against the viral protease are often hampered by drug resistance mutations in protease and in the viral substrate Gag. To overcome this drug resistance and inhibit viral maturation, targeting Gag alongside protease rather than ...
Chinh Tran-To Su, Darius Wen-Shuo Koh, Samuel Ken-En Gan   +2 more
doaj   +1 more source

Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers

Pharmaceutics, 2023
Despite the availability of currently approved antiviral drugs, infections with human cytomegalovirus (HCMV) still cause clinically challenging, sometimes life-threatening situations.
Markus Wild, Dubravka Karner, Jan Eickhoff, Sabrina Wagner, Jintawee Kicuntod, William Chang, Peter Barry, Stipan Jonjić, Tihana Lenac Roviš, Manfred Marschall   +9 more
doaj   +1 more source

Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients

Advances in Virology, 2011
Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus reported to be associated with human prostate cancer and chronic fatigue syndrome. Since retroviruses cause various cancers, and XMRV replication might be facilitated by HIV-1 co-
Krista A. Delviks-Frankenberry, Chawaree Chaipan, Rachel Bagni, Kathleen Wyvill, Robert Yarchoan, Vinay K. Pathak   +5 more
doaj   +1 more source

The HIV-1 Reverse Transcriptase A62V Mutation Influences Replication Fidelity and Viral Fitness in the Context of Multi-Drug-Resistant Mutations

Viruses, 2018
Emergence of human immunodeficiency virus type 1 (HIV-1) drug resistance arises from mutation fixation in the viral genome during antiretroviral therapy. Primary mutations directly confer antiviral drug resistance, while secondary mutations arise that do
José O. Maldonado, Louis M. Mansky
doaj   +1 more source

Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya

AIDS Research and Therapy, 2009
Access to antiretroviral therapy (ART) is increasing in resource-limited settings (RLS) and can successfully reduce HIV-related morbidity and mortality.
Reynaerts Jacqueline, Dauwe Kenny, Luchters Stanley, Steegen Kim, Mandaliya Kishor, Jaoko Walter, Plum Jean, Temmerman Marleen, Verhofstede Chris   +8 more
doaj   +1 more source

Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients

Retrovirology, 2012
Background The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, and therefore are expected to ...
Theys Kristof, Deforche Koen, Vercauteren Jurgen, Libin Pieter, van de Vijver David AMC, Albert Jan, Åsjö Birgitta, Balotta Claudia, Bruckova Marie, Camacho Ricardo J, Clotet Bonaventura, Coughlan Suzie, Grossman Zehava, Hamouda Osamah, Horban Andrzei, Korn Klaus, Kostrikis Leondios G, Kücherer Claudia, Nielsen Claus, Paraskevis Dimitrios, Poljak Mario, Puchhammer-Stockl Elisabeth, Riva Chiara, Ruiz Lidia, Liitsola Kirsi, Schmit Jean-Claude, Schuurman Rob, Sönnerborg Anders, Stanekova Danica, Stanojevic Maja, Struck Daniel, Van Laethem Kristel, Wensing Annemarie MJ, Boucher Charles AB, Vandamme Anne-Mieke   +34 more
doaj   +1 more source

Pressurized DNA state inside herpes capsids-A novel antiviral target.

PLoS Pathogens, 2020
Drug resistance in viruses represents one of the major challenges of healthcare. As part of an effort to provide a treatment that avoids the possibility of drug resistance, we discovered a novel mechanism of action (MOA) and specific compounds to treat ...
Alberto Brandariz-Nuñez, Scott J Robinson, Alex Evilevitch   +2 more
doaj   +1 more source

Future of Antiretroviral Drugs and Evolution of HIV-1 Drug Resistance

Viruses, 2023
Highly active antiretroviral (ARV) therapy has been used for many years, but the use in low- and middle-income countries of antiretroviral drugs with low genetic barrier to resistance, combined with limited availability of viral load testing, has led to ...
Charlotte Charpentier, Quentin Le Hingrat, Valentine Marie Ferré, Florence Damond, Diane Descamps   +4 more
doaj   +1 more source

Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 338)

AIDS Research and Therapy, 2007
Background The association between baseline drug resistance mutations and subsequent increase in viral failure has not been established for HIV-infected children.
McIntosh Kenneth, Yogev Ram, Mofenson Lynne M, Wiznia Andrew A, Hu Chengcheng, Petch Leslie A, Kovacs Andrea, Fiscus Susan A, Pelton Stephen I, Napravnik Sonia, Stanley Kenneth, Nachman Sharon A   +11 more
doaj   +1 more source