Results 11 to 20 of about 334,676 (308)

Life cycle synchronization is a viral drug resistance mechanism. [PDF]

PLoS Computational Biology, 2018
Viral infections are one of the major causes of death worldwide, with HIV infection alone resulting in over 1.2 million casualties per year. Antiviral drugs are now being administered for a variety of viral infections, including HIV, hepatitis B and C ...
Iulia A Neagu, Jason Olejarz, Mark Freeman, Daniel I S Rosenbloom, Martin A Nowak, Alison L Hill   +5 more
doaj   +11 more sources

Improving Viral Protease Inhibitors to Counter Drug Resistance [PDF]

Trends in Microbiology, 2016
Drug resistance is a major problem in health care, undermining therapy outcomes and necessitating novel approaches to drug design. Extensive studies on resistance to viral protease inhibitors, particularly those of HIV-1 and hepatitis C virus (HCV) protease, revealed a plethora of information on the structural and molecular mechanisms underlying ...
Yilmaz, Nese Kurt, Swanstrom, Ronald I., Schiffer, Celia A.   +2 more
core   +6 more sources

An MHV-68 Mutator Phenotype Mutant Virus, Confirmed by CRISPR/Cas9-Mediated Gene Editing of the Viral DNA Polymerase Gene, Shows Reduced Viral Fitness

Viruses, 2021
Drug resistance studies on human γ-herpesviruses are hampered by the absence of an in vitro system that allows efficient lytic viral replication. Therefore, we employed murine γ-herpesvirus-68 (MHV-68) that efficiently replicates in vitro as a model to ...
Erika Trompet, Arturo Temblador, Sarah Gillemot, Dimitrios Topalis, Robert Snoeck, Graciela Andrei   +5 more
doaj   +2 more sources

Nationwide Estimates of Viral Load Suppression and Acquired HIV Drug Resistance in Cameroon [PDF]

EClinicalMedicine, 2018
Population-based studies to estimate viral load (VL) suppression and rate of acquired HIV drug resistance (ADR) are essential in sub-Saharan Africa. We conducted the first nationally representative study estimating VL suppression and ADR in Cameroon.Eligible participants were patients on antiretroviral therapy (ART) for 12 to 24 months (ART 12-24) or ...
Sabrina Eymard-Duvernay, Amandine Cournil, Laetitia Serrano   +2 more
exaly   +5 more sources

Conquering viral drug resistance: Structural and mechanistic paradigms for antiresistance drug design

Pharmaceutical Science Advances
Viral drug resistance remains a critical challenge in antiviral therapy. This perspective highlights five studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human immunodeficiency virus type 1 (HIV-1), monkeypox virus (MPXV ...
Mei Wang, Haiyong Jia, Xinyong Liu, Peng Zhan   +3 more
doaj   +3 more sources

“I feel drug resistance testing allowed us to make an informed decision”: qualitative insights on the role of HIV drug resistance mutation testing among children and pregnant women living with HIV in western Kenya

BMC Health Services Research, 2023
Background Pregnant women and children living with HIV in Kenya achieve viral suppression (VS) at lower rates than other adults. While many factors contribute to these low rates, the acquisition and development of HIV drug resistance mutations (DRMs) are
Andrea J. Scallon, Shukri A. Hassan, Shirley Rui Qian, Yuandi Gao, Patrick Oyaro, Evelyn Brown, James Wagude, Irene Mukui, Eunice Kinywa, Frederick Oluoch, Francesca Odhiambo, Boaz Oyaro, Leonard Kingwara, Nashon Yongo, Enericah Karauki, Lindah Otieno, Grace C. John-Stewart, Lisa L. Abuogi, Rena C. Patel   +18 more
doaj   +1 more source

HIV-1 resistance profile in plasma and peripheral blood lymphocytes in a group of naive patients [PDF]

Archives of Biological Sciences, 2012
Transmitted HIV-1 drug resistance (TDR) is a persisting problem, even though the prevalence of primary resistance may remain stable or start to decline.
Šiljić Marina, Salemović Dubravka, Jevtović Đ., Pešić-Pavlović Ivana, Zerjav Sonja, Nikolić Valentina, Stanojević Maja   +6 more
doaj   +1 more source

Uptake of antiretroviral treatment and viral suppression among men who have sex with men and transgender women in sub-Saharan Africa in an observational cohort study: HPTN 075

International Journal of Infectious Diseases, 2021
Objectives: HPTN 075 enrolled men who have sex with men (MSM) and transgender women (TGW) in sub-Saharan Africa. Persons in HIV care or on antiretroviral treatment (ART) were not eligible to enroll.
Philip J. Palumbo, Yinfeng Zhang, William Clarke, Autumn Breaud, Mariya Sivay, Vanessa Cummings, Erica L. Hamilton, Xu Guo, Arthur Ogendo, Noel Kayange, Ravindre Panchia, Karen Dominguez, Ying Q. Chen, Theodorus G.M. Sandfort, Susan H. Eshleman   +14 more
doaj   +1 more source

Treatment effect and drug-resistant mutations in Chinese AIDS patients switching to second-line antiretroviral therapy. [PDF]

PLoS ONE, 2014
This study aimed to investigate treatment effect, drug resistance changes, and their influencing factors in Chinese AIDS patients after switching to second-line antiretroviral therapy, and thus provide important information for the scale-up of second ...
Min Zhang, Mingquan Shang, Weiwei Yang, Junli Chen, Zhe Wang, Hong Shang   +5 more
doaj   +1 more source

Potential challenges to sustained viral load suppression in the HIV treatment programme in South Africa: a narrative overview

AIDS Research and Therapy, 2021
Background South Africa, with one of the highest HIV prevalences in the world, introduced the universal test and treat (UTT) programme in September 2016.
Pascal O. Bessong, Nontokozo D. Matume, Denis M. Tebit   +2 more
doaj   +1 more source