Results 71 to 80 of about 334,676 (308)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration [PDF]

, 2005
Background The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate.Methods and ...
Wynhoven, B, Cane, P, Holguin, A, Pedro Cahn, Maria Belen Bouzas, Africa Holguin, Luis F Brigido, Sirivichayakul, S, Anne-Mieke Vandamme, Camacho, R, Efron, B, Koya Ariyoshi, Grossman, Z, Robert W Shafer, Shafer, RW, Bouzas, MB, Brian Wynhoven, Ricardo Camacho, Jonathan N Weber, Harrigan, PR, Ariyoshi, K, Ana Patricia Carvalho, Rosangela Rodrigues, Rudich, H, Candice Pillay, Soares, MA, Katzenstein, DA, Vandamme, AM, Clarke, J, Lynn Morris, Snoeck, J, Soriano, V, Rodrigues, R, Brigido, LF, Wataru Sugiura, Praphan Phanuphak, Kantor, R, Sugiura, W, John Clarke, Jonathan M Schapiro, Rami Kantor, David A Katzenstein, Carvalho, AP, P Richard Harrigan, Patricia Cane, Phanuphak, P, Brad Efron, Pillay, D, Pillay, C, Sunee Sirivichayakul, Joke Snoeck, Cahn, P, Hagit Rudich, Schapiro, JM, Morris, L, Zehava Grossman, Amilcar Tanuri, Tanuri, A, Weber, JN, Vincent Soriano, Deenan Pillay, Marcelo A Soares   +61 more
core   +1 more source

Loss and recovery of genetic diversity in adapting populations of HIV. [PDF]

PLoS Genetics, 2014
The evolution of drug resistance in HIV occurs by the fixation of specific, well-known, drug-resistance mutations, but the underlying population genetic processes are not well understood.
Pleuni S Pennings, Sergey Kryazhimskiy, John Wakeley   +2 more
doaj   +1 more source

Targeting Human Proteins for Antiviral Drug Discovery and Repurposing Efforts: A Focus on Protein Kinases

Viruses, 2023
Despite the great technological and medical advances in fighting viral diseases, new therapies for most of them are still lacking, and existing antivirals suffer from major limitations regarding drug resistance and a limited spectrum of activity. In fact,
Rima Hajjo, Dima A. Sabbah, Osama H. Abusara, Reham Kharmah, Sanaa Bardaweel   +4 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants

, 2010
Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease ...
Stefan Zeuzem, Randle, John C. R., Randle John C. R., Lin, Chao, Kwong Ann D., Bambang S Adiwijaya, John C. R. Randle, Sarrazin, Christoph, Paul R. Caron, Herrmann Eva, Zeuzem Stefan, Christoph Sarrazin, Garg Varun, Kieffer, Tara, Brian Hare, Hare, Brian, Varun Garg, Lin Chao, Kieffer Tara, Herrmann, Eva, Caron, Paul R., Kwong, Ann D., Tara Kieffer, Ann D Kwong, Sarrazin Christoph, Chao Lin, Bambang S. Adiwijaya, Adiwijaya, Bambang S., Hare Brian, Paul R Caron, Caron Paul R., Garg, Varun, Eva Herrmann, Ann D. Kwong, John C R Randle, Adiwijaya Bambang S., Zeuzem, Stefan   +36 more
core   +1 more source

[Viral drug resistance].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2008
More and more viral infections are treated with antiviral drugs, and resistance against these drugs is steadily increasing. Our aim is to give a general understanding of viral resistance and its clinical significance.This article is based on review of published literature on the subject, international recommendations and our own experience as a ...
Susanne Gjeruldsen, Dudman, Kathrine, Stene-Johansen, Inger Sofie Samdal, Vik   +2 more
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain

, 2005
Known human immunodeficiency virus (HIV) transmission histories are invaluable models for investigating the evolutionary and transmission dynamics of the virus and to assess the accuracy of phylogenetic reconstructions.
A.-M. Vandamme, Lemey, P, A. Rambaut, Dumont, Stephanie, S. Dumont, Van Wijngaerden, Eric, Vandamme, A M, K. Van Laethem, Rambaut, Andrew, Vermeulen, Steve, S. Vermeulen, E. Van Wijngaerden, Dumont, S, Vandamme, Anne-Mieke, P. Lemey, Rambaut, A, Van Laethem, Kristel, Lemey, Philippe, I. Derdelinckx, Van Wijngaerden, E, Derdelinckx, Inge, Vermeulen, S, Van Laethem, K, Derdelinckx, I   +23 more
core   +1 more source

Statin (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor)-based therapy for hepatitis C virus (HCV) infection-related diseases in the era of direct-acting antiviral agents [version 2; referees: 2 approved]

F1000Research, 2016
Recent improvements have been made in the treatment of hepatitis C virus (HCV) infection with the introduction of direct-acting antiviral agents (DAAs).
Sara Kishta, Reem EI-Shenawy, Sobhy Kishta   +2 more
doaj   +1 more source