Results 81 to 90 of about 507,510 (307)

HIV drug resistance in persons who inject drugs enrolled in an HIV prevention trial in Indonesia, Ukraine, and Vietnam: HPTN 074.

PLoS ONE, 2019
BackgroundPersons who inject drugs (PWID) have high HIV incidence and prevalence, and may have limited access to antiretroviral therapy (ART) in some settings. We evaluated HIV drug resistance in PWID in a randomized clinical trial (HPTN 074).
Philip J Palumbo, Yinfeng Zhang, Jessica M Fogel, Xu Guo, William Clarke, Autumn Breaud, Paul Richardson, Estelle Piwowar-Manning, Stephen Hart, Erica L Hamilton, Ngo T K Hoa, Mariya Liulchuk, Latifah Anandari, Tran Viet Ha, Kostyantyn Dumchev, Zubairi Djoerban, Irving Hoffman, Brett Hanscom, William C Miller, Susan H Eshleman   +19 more
doaj   +1 more source

Patient needs and point-of-care requirements for HIV load testing in resource-limited settings [PDF]

, 2010
Medecins Sans Frontieres (MSF) is an international, independent medical nongovernmental organization. One way in which MSF acts to improve patient care is to assist in the identification and development of adapted and appropriate tools for use in ...
Calmy, Alexandra, Guillerm, Martine, Usdin, Martine   +2 more
core   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. [PDF]

, 2005
Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g ...
Back, DJ, Bray, PG, Chandler, B, Hart, CA, Hartkoorn, RC, Janneh, O, Khoo, SH, Martin, P, Owen, A, Ward, SA   +9 more
core   +1 more source

Structure-activity relationships of fluorene compounds inhibiting HCV variants [PDF]

, 2020
Approximately 71 million people suffer from hepatitis C virus (HCV) infection worldwide. Persistent HCV infection causes liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma, resulting in approximately 400,000 deaths ...
Gadhe, Changdev G., JANG, SUNG KEY, Keum, Gyochang, Kim, Byeong Moon, Kim, Hee Sun, Kohara, Michinori, Lee, Jae Seung, Moon, Heejo, Mun, Jaegon, Pae, Ae Nim, You, Youngsu   +10 more
core   +1 more source

Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance

Cell
DNA polymerases are important drug targets, and many structural studies have captured them in distinct conformations. However, a detailed understanding of the impact of polymerase conformational dynamics on drug resistance is lacking. We determined cryoelectron microscopy (cryo-EM) structures of DNA-bound herpes simplex virus polymerase holoenzyme in ...
Shankar, Sundaresh, Pan, Junhua, Yang, Pan, Bian, Yuemin, Oroszlán, Gábor, Yu, Zishuo, Mukherjee, Purba, Filman, David J, Hogle, James M, Shekhar, Mrinal, Coen, Donald M, Abraham, Jonathan   +11 more
openaire   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Low prevalence of hepatitis C co-infection in recently HIV-infected minority men who have sex with men in Los Angeles: a cross-sectional study. [PDF]

, 2015
BackgroundGeographic and sociodemographic characterization of hepatitis C virus (HCV) transmission amongst men who have sex with men (MSM) has been limited.
Bhattacharya, Debika, Blum, Martha L, Bolan, Robert, Bornfleth, Lorelei D, Chew, Kara W, Clare, Laurel E, Gorbach, Pamina M, Javanbakht, Marjan   +7 more
core   +2 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

HIV resistance to anti-viral drugs.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1994
The use of zidovudine (ZDV) and other forms of nucleoside therapy, including dideoxyinosine (ddI), to treat HIV-infected individuals has led to both longer survival and improved quality of life. However, ZDV-resistant variants of HIV-1 can be isolated from patients undergoing prolonged therapy with this drug.
M A, Wainberg, H, Salomon, B, Spira, L, Mercure, J, Wainberg, K, Nagai, Z, Bentwich, J, Montaner   +7 more
openaire   +1 more source