Results 11 to 20 of about 7,262,600 (380)
Drugging Drug Resistance [PDF]
Cell, 2010 Resistance to anticancer drugs is widely observed in vitro and in cancer patients, but its prevalence is too high to be solely explained by the acquisition of mutations. Sharma et al. (2010) now report that dynamic chromatin modifications may be an independent route to drug resistance in cancer cells that can be reversed by epigenetic drugs.
Anton Berns, Jan-Hermen Dannenberg
openaire +3 more sources
BMC Infectious Diseases, 2023 Background The World Health Organization has reported that the treatment success rate of multi-drug resistance tuberculosis is approximately 57% globally. Although new drugs such as bedaquiline and linezolid is likely improve the treatment outcome, there
J-B Ma +9 more
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Experimental Closed-Loop Control of Breast Cancer in Mice
Complexity, 2022 Cancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer.
Levente Kovács +7 more
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Molecular Mechanisms of Drug Resistance in Staphylococcus aureus
International Journal of Molecular Sciences, 2022 This paper discusses the mechanisms of S. aureus drug resistance including: (1) introduction. (2) resistance to beta-lactam antibiotics, with particular emphasis on the mec genes found in the Staphylococcaceae family, the structure and occurrence of ...
B. Młynarczyk-bonikowska +3 more
semanticscholar +1 more source
mSystems, 2021 Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functional genome ...
Samuel J. Modlin +10 more
doaj +1 more source
Burden of malaria infection among individuals of varied blood groups in Kenya
Malaria Journal, 2022 Background The ABO blood groups consist of A, B, and H carbohydrate antigens, which regulate protein activities during malaria infection in humans.
Redemptah Yeda +17 more
doaj +1 more source
Pharmaceuticals, 2023 Antibiotics have revolutionized medicine, saving countless lives since their discovery in the early 20th century. However, the origin of antibiotics is now overshadowed by the alarming rise in antibiotic resistance.
Ghazala Muteeb +3 more
semanticscholar +1 more source
The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review
Cancers, 2021 Simple Summary Drug resistance remains one of the major problems in cancer therapy and is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and treatment; thus, determining how to overcome this problem is a goal ...
F. Rascio +6 more
semanticscholar +1 more source
Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance
Frontiers in Immunology, 2021 The tumor microenvironment (TME) is a complex and ever-changing “rogue organ” composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells and extracellular matrix (ECM).
Khalil Khalaf +5 more
semanticscholar +1 more source
Advancing Drug Resistance Research Through Quantitative Modeling and Synthetic Biology [PDF]
Frontiers in Bioengineering and Biotechnology, 8: 583415 (2020), 2020 Antimicrobial resistance is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050. Research over the last decade has demonstrated that the differences between genetically identical cells in the same environment can lead to drug resistance ...
arxiv +1 more source