Results 11 to 20 of about 8,375,389 (400)

Development and validation of a prediction model for unsuccessful treatment outcomes in patients with multi-drug resistance tuberculosis

BMC Infectious Diseases, 2023
Background The World Health Organization has reported that the treatment success rate of multi-drug resistance tuberculosis is approximately 57% globally. Although new drugs such as bedaquiline and linezolid is likely improve the treatment outcome, there
J-B Ma, L-C Zeng, F Ren, L-Y Dang, H Luo, Y-Q Wu, X-J Yang, R Li, H Yang, Y Xu   +9 more
doaj   +1 more source

Treatment of tuberculosis in a region with high drug resistance: Outcomes, drug resistance amplification and re-infection [PDF]

, 2011
Introduction: Emerging antituberculosis drug resistance is a serious threat for tuberculosis (TB) control, especially in Eastern European countries. Methods: We combined drug susceptibility results and molecular strain typing data with treatment outcome ...
Andrew, P W, Barer, M, Bonnet, M, Checchi, F, Fattorini, L, Jarosz, T, Meacci, F, Melzer, J, Niemann, S, Oggioni, M R, Orefici, G, Orrù, G, Pardini, M, Rinder, H, Rüsch-Gerdes, S, Varaine, F, Yesilkaya, H   +16 more
core   +14 more sources

Molecular Mechanisms of Drug Resistance in Staphylococcus aureus

International Journal of Molecular Sciences, 2022
This paper discusses the mechanisms of S. aureus drug resistance including: (1) introduction. (2) resistance to beta-lactam antibiotics, with particular emphasis on the mec genes found in the Staphylococcaceae family, the structure and occurrence of ...
B. Młynarczyk-bonikowska, C. Kowalewski, Aneta Królak-Ulińska, W. Marusza   +3 more
semanticscholar   +1 more source

Experimental Closed-Loop Control of Breast Cancer in Mice

Complexity, 2022
Cancer therapy optimization is an issue that can be solved using the control engineering approach. An optimal therapy generation algorithm is presented and tested using a tractable mouse model of breast cancer.
Levente Kovács, Bence Czakó, Máté Siket, Tamás Ferenci, András Füredi, Balázs Gombos, Gergely Szakács, Dániel András Drexler   +7 more
doaj   +1 more source

Structure-Aware Mycobacterium tuberculosis Functional Annotation Uncloaks Resistance, Metabolic, and Virulence Genes

mSystems, 2021
Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functional genome ...
Samuel J. Modlin, Afif Elghraoui, Deepika Gunasekaran, Alyssa M. Zlotnicki, Nicholas A. Dillon, Nermeeta Dhillon, Norman Kuo, Cassidy Robinhold, Carmela K. Chan, Anthony D. Baughn, Faramarz Valafar   +10 more
doaj   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant, A Dube, A Mehta, A Mukherjee, AB Sidhu, AC Coelho, AH Fairlamb, Ashutosh, B Gourbal, B Vergnes, Basudha Khanal, BJ Mookerjee, C Brochu, C Dumas, CS Ferreira, D Legare, DM Weinreich, F Chappuis, F Frezard, G Mandal, Graham H. Coombs, H Denton, H Shim, Hideo Imamura, HW Murray, J Alvar, J Hellemans, J Mikus, J Tovar, JC Mottram, JC Munday, Jean-Claude Dujardin, JM Kelly, K Ait-Oudhia, K Grondin, KC Carter, Kirstyn Brunker, KW Tintaya, L Flohe, M Maharjan, M Samant, M Vanaerschot, Manu Vanaerschot, MK Mittal, ML Cunningham, MR Ariyanayagam, MR Perry, N Beerenwinkel, N Singh, N Van Meirvenne, P Baiocco, PJ Alcolea, PR Romao, R Hadighi, R Lira, R Mukhopadhyay, R Rojas, R Singh, RA Williams, RI da Luz, RL Krauth-Siegel, RL Krauth-Siegel, S Borrell, S Decuypere, S Dey, S Gagneux, S Mandal, S Muller, S Rais, S Rijal, S Sundar, S Wyllie, S Wyllie, S Yan, S Yan, Saskia Decuypere, Suman Rijal, Sylke Müller, T Downing, T Downing, T Laurent, T Nozaki, Timothy G. Geary, V Adaui, V Yardley, Y Zhou   +85 more
core   +11 more sources

Burden of malaria infection among individuals of varied blood groups in Kenya

Malaria Journal, 2022
Background The ABO blood groups consist of A, B, and H carbohydrate antigens, which regulate protein activities during malaria infection in humans.
Redemptah Yeda, Charles Okudo, Eunice Owiti, Gladys Biwot, Cliff Momanyi, Winnie Korir, Thoya Mitsanze, Caroline Tegerei, Dennis Juma, Benjamin Opot, Edwin Mwakio, Gladys Chemwor, Raphael Okoth, Douglas O. Ochora, Agnes C. Cheruiyot, Amanda Roth, Hoseah M. Akala, Ben Andagalu   +17 more
doaj   +1 more source

The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review

Cancers, 2021
Simple Summary Drug resistance remains one of the major problems in cancer therapy and is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and treatment; thus, determining how to overcome this problem is a goal ...
F. Rascio, F. Spadaccino, M. Rocchetti, G. Castellano, G. Stallone, G. Netti, E. Ranieri   +6 more
semanticscholar   +1 more source

Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance

International Journal on Biological Sciences, 2022
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic failure.
Aiping Zhang, Kai Miao, Heng Sun, Chuxia Deng   +3 more
semanticscholar   +1 more source

Infection and Drug Resistance

, 2022
Dr Benjamin A H Jensen Dr Aarabi Dr Mera A Ababneh Dr Albert Abaka-Yawson Dr Mohamed Salah Abassi Dr Getahun Abate Dr Tarek Mohamed Abd ElAziz Dr Rehab M Abd El-Baky Dr Amir Abdoli Dr Akebe Luther King Abia Dr Fatma Ben Abid Prof Dr Khaled M Aboshanab Mr
Mohd Abdul-Aziz, Khaled Aboshanab
semanticscholar   +1 more source