Results 11 to 20 of about 1,232,228 (310)
PLoS Medicine, 2017 Resistance to first-line treatments for Plasmodium falciparum malaria and the insecticides used for Anopheles vector control are threatening malaria elimination efforts. Suboptimal responses to drugs and insecticides are both spreading geographically and
malERA Refresh Consultative Panel on Insecticide and Drug Resistance
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Drug Resistance in Leishmaniasis [PDF]
Journal of Global Infectious Diseases, 2010 The treatment options of leishmaniasis are limited and far from satisfactory. For more than 60 years, treatment of leishmaniasis has centered around pentavalent antimonials (Sb(v)). Widespread misuse has led to the emergence of Sb(v) resistance in the hyperendemic areas of North Bihar. Other antileishmanials could also face the same fate, especially in
Shyam Sundar, Jaya Chakravarty
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eLife, 2020 This study assembles DNA adenine methylomes for 93 Mycobacterium tuberculosis complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo assembled genomes. Integrative analysis yielded four key results.
Samuel J Modlin +9 more
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Drug Repurposing Opportunities in Pancreatic Ductal Adenocarcinoma
Pharmaceuticals, 2021 Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest tumors worldwide. The diagnosis is often possible only in the latter stages of the disease, with patients already presenting an advanced or metastatic tumor. It is also one of the
Rita Rebelo +4 more
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Drug resistance and combating drug resistance in cancer
Cancer Drug Resistance, 2019 Cancer is the second leading cause of death in the US. Current major treatments for cancer management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy, endocrine therapy and immunotherapy. Despite the endeavors and achievements made in treating cancers during the past decades, resistance to classical chemotherapeutic agents ...
Xiaozhuo Chen, Haiyun Zhang, Xuan Wang
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Survival outcomes of autologous breast reconstruction after mastectomy: A matched case-control study
Frontiers in Oncology, 2023 BackgroundDue to the lack of strong evidence-based medical evidence, the relationship between autologous breast reconstruction (ABR) after mastectomy and long-term prognosis is unclear.
Shang Wu +11 more
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Resisting Bacterial Drug Resistance [PDF]
Chemistry & Biology, 2003 In this issue of Chemistry & Biology, Wright and colleagues report an elegant method for inhibiting enzymes critical for rendering bacteria drug resistant. By using cationic peptides as inhibitors, the authors have exploited two antibacterial mechanisms, making it doubly difficult for microbial retaliation.
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Drug resistant tuberculosis [PDF]
BMJ, 1995 EDITOR,—Concern is growing over the spread of drug resistant Mycobacterium tuberculosis. New evidence suggests that this spread may be increasing in certain sections of the British population. The recent advances in molecular techniques have equipped us with the means to make substantial inroads into the possible impact of drug resistant tuberculosis.1
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Biomedicines, 2023 Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes that escape death, and correlates with the expression of negative prognostic markers such as the CD38 antigen.
Brigitte Bauvois +5 more
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Rv1453 is associated with clofazimine resistance in Mycobacterium tuberculosis
Microbiology Spectrum, 2023 Clofazimine (CFZ) has been repurposed for treating tuberculosis (TB), especially multidrug-resistant tuberculosis (MDR-TB). However, the mechanisms of resistance to clofazimine are poorly understood.
Lei Zhang +9 more
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