Results 1 to 10 of about 4,670,790 (255)

Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update. [PDF]

PLoS ONE, 2009
Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs.
Diane E Bennett, Ricardo J Camacho, Dan Otelea, Daniel R Kuritzkes, Hervé Fleury, Mark Kiuchi, Walid Heneine, Rami Kantor, Michael R Jordan, Jonathan M Schapiro, Anne-Mieke Vandamme, Paul Sandstrom, Charles A B Boucher, David van de Vijver, Soo-Yon Rhee, Tommy F Liu, Deenan Pillay, Robert W Shafer   +17 more
doaj   +3 more sources

Predicting Anticancer Drug Resistance Mediated by Mutations

Pharmaceuticals, 2022
Cancer drug resistance presents a challenge for precision medicine. Drug-resistant mutations are always emerging. In this study, we explored the relationship between drug-resistant mutations and drug resistance from the perspective of protein structure ...
Yu-Feng Lin, Jia-Jun Liu, Yu-Jen Chang, Chin-Sheng Yu, Wei Yi, Hsien-Yuan Lane, Chih-Hao Lu   +6 more
doaj   +3 more sources

Deep Contrastive Learning for High-Throughput Prediction of Drug Resistance Mutations from Sequences. [PDF]

Adv Sci (Weinh)
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Hu X, Zhang P, Wu S, Sun H, Li M, Tsoka S, Sheng Z, Deng L.   +7 more
europepmc   +2 more sources

Hepatitis B virus genotypes and antiviral drug resistance mutations in treatment-naïve patients with chronic hepatitis B in Bacninh, Vietnam: a cross-sectional study

Therapeutic Advances in Infectious Disease
Background: Vietnam has one of the highest hepatitis B virus (HBV) infection rates, with approximately 8 million people affected. Although antiviral drug resistance mutations have been reported in treatment-naïve patients with chronic hepatitis B, there ...
Minh-Cong Hoang, Hong-Quan Duong, Van-Duyet Le, Thi-Thuy-Nga Nguyen, Van-Lang Ngo, The-Hung Dang   +5 more
doaj   +2 more sources

Research progress of ALK kinase domain drug resistance mutation and its future countermeasures [PDF]

Zhongguo aizheng zazhi, 2022
Anaplastic lymphoma kinase (ALK) is one of the common oncogenic driver genes in non-small cell lung cancer (NSCLC). Tyrosine kinase inhibitors (TKIs) have achieved excellent therapeutic effects in patients with ALK fusion positive NSCLC.
Liyuan HE, Yudong WANG
doaj   +2 more sources

Assessment of a Computational Approach to Predict Drug Resistance Mutations for HIV, HBV and SARS-CoV-2

Molecules, 2022
Viral resistance is a worldwide problem mitigating the effectiveness of antiviral drugs. Mutations in the drug-targeting proteins are the primary mechanism for the emergence of drug resistance. It is essential to identify the drug resistance mutations to
Dharmeshkumar Patel, Suzane K. Ono, Leda Bassit, Kiran Verma, Franck Amblard, Raymond F. Schinazi   +5 more
doaj   +1 more source

Association of preexisting drug-resistance mutations and treatment failure in hepatitis B patients. [PDF]

PLoS ONE, 2013
The role of preexisting minority drug-resistance mutations in treatment failure has not been fully understood in chronic hepatitis B patients. To understand mechanisms of drug resistance, we analyzed drug-resistance mutations in 46 treatment-failure ...
Jie Ma, Yingchun Zhang, Xinyue Chen, Yi Jin, Dexi Chen, Yun Wu, Jing Cui, Haitao Wang, Jia Liu, Ning Li, Feng Gao   +10 more
doaj   +1 more source

Drug resistant Mycobacterium tuberculosis in Oman: resistance-conferring mutations and lineage diversity [PDF]

PeerJ, 2022
Background The Sultanate of Oman is country a low TB-incidence, with less than seven cases per 105 population detected in 2020. Recent years have witnessed a persistence in TB cases, with sustained incidence rate among expatriates and limited reduction ...
Sara Al Mahrouqi, Amal Gadalla, Saleh Al Azri, Salama Al-Hamidhi, Amina Al-Jardani, Abdullah Balkhair, Amira Al-fahdi, Laila Al Balushi, Samiya Al Zadjali, Asmahan Mohammed Nasser Al Marhoubi, Hamza A. Babiker   +10 more
doaj   +2 more sources

Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naïve populations and associate with reduced treatment efficacy. [PDF]

PLoS Medicine, 2008
BACKGROUND: Transmitted HIV-1 drug resistance can compromise initial antiretroviral therapy (ART); therefore, its detection is important for patient management.
Jeffrey A Johnson, Jin-Fen Li, Xierong Wei, Jonathan Lipscomb, David Irlbeck, Charles Craig, Amanda Smith, Diane E Bennett, Michael Monsour, Paul Sandstrom, E Randall Lanier, Walid Heneine   +11 more
doaj   +1 more source

Detection of antiviral drug resistance in patients with congenital cytomegalovirus infection using long-read sequencing: a retrospective observational study

BMC Infectious Diseases, 2022
Background Congenital human cytomegalovirus (cCMV) infection can cause sensorineural hearing loss and neurodevelopmental disabilities in children. Ganciclovir and valganciclovir (GCV/VGCV) improve long-term audiologic and neurodevelopmental outcomes for ...
Yuka Torii, Kazuhiro Horiba, Jun-ichi Kawada, Kazunori Haruta, Makoto Yamaguchi, Takako Suzuki, Hideko Uryu, Naoyuki Kashiwa, Keiji Goishi, Tomoo Ogi, Yoshinori Ito   +10 more
doaj   +1 more source