Results 21 to 30 of about 4,670,790 (255)

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Rosalba Lepore, LEPORE, ROSALBA, Pillai, DR, Via Allegra, K. Khairnar, Khairnar Krishna, Rachel Lau, Pillai Dylan R, D. R. Pillai, VIA, ALLEGRA, Dylan R Pillai, Henry M Staines, Krishna Sanjeev, S. Krishna, Lau, R, Khairnar, K, Lau Rachel, Via, A, Staines, HM, H. M. Staines, Krishna, S, Sanjeev Krishna, Krishna Khairnar, Lepore, R, Allegra Via, R. Lau, Lepore Rosalba, Staines Henry M   +27 more
core   +1 more source

The Geogenomic Mutational Atlas of Pathogens (GoMAP) web system.

PLoS ONE, 2014
We present a new approach for pathogen surveillance we call Geogenomics. Geogenomics examines the geographic distribution of the genomes of pathogens, with a particular emphasis on those mutations that give rise to drug resistance.
David P Sargeant, Michael W Hedden, Sandeep Deverasetty, Christy L Strong, Izua J Alaniz, Alexandria N Bartlett, Nicholas R Brandon, Steven B Brooks, Frederick A Brown, Flaviona Bufi, Monika Chakarova, Roxanne P David, Karlyn M Dobritch, Horacio P Guerra, Kelvy S Levit, Kiran R Mathew, Ray Matti, Dorothea Q Maza, Sabyasachy Mistry, Nemanja Novakovic, Austin Pomerantz, Timothy F Rafalski, Viraj Rathnayake, Noura Rezapour, Christian A Ross, Steve G Schooler, Sarah Songao, Sean L Tuggle, Helen J Wing, Sandy Yousif, Martin R Schiller   +30 more
doaj   +1 more source

HIV-1 subtypes and pre-treatment drug resistance in newly reported HIV-1-infected cases in Hongkou District， Shanghai in 2016

Shanghai yufang yixue, 2022
ObjectiveTo determine the HIV-1 subtypes and pre-treatment drug resistance （PDR） mutations in newly reported HIV-1-infected cases in Hongkou District of Shanghai， and provide evidence for the adjustment of antiretroviral therapy （ART）.MethodsA total of ...
HONG Liang, TAO Jing, LI Jiajie, JIA Min
doaj   +1 more source

Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa [PDF]

, 2013
South Africa shows one of the highest global burdens of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Since 2002, MDR-TB in South Africa has been treated by a standardized combination therapy, which until 2010 included
Pillay, Manormoney, van Helden, Paul D., Nicolaas C. Gey van Pittius (173264), Paul D. van Helden (33594), Marlein E Bosman, Gagneux, Sebastien, Thomas C Victor, Manormoney Pillay (257769), Nicolaas C Gey van Pittius, Borna Müller (173253), Hayes, Cindy, Streicher, Elizabeth M., Andre Trollip (449922), Robin M Warren, Elizabeth M Streicher, Trollip, Andre, Violet N. Chihota (143307), Warren, Robin M., Bosman, Marlein E., Müller, Borna, Violet N Chihota, Cindy Hayes, Marisa Klopper (398815), Cindy Hayes (449923), Elizabeth M. Streicher (439727), Borna Müller, Paul D van Helden, Marlein E. Bosman (449924), Klopper, Marisa, Gerrit Coetzee, Sebastien Gagneux (149824), Chihota, Violet N., Andre Trollip, Marisa Klopper, Sebastien Gagneux, Gerrit Coetzee (296078), Victor, Thomas C., Manormoney Pillay, Coetzee, Gerrit, Gey van Pittius, Nicolaas C., Robin M. Warren (33593), Thomas C. Victor (185348)   +41 more
core   +2 more sources

Low Incidence of HIV-1C Acquired Drug Resistance 10 Years after Roll-Out of Antiretroviral Therapy in Ethiopia: A Prospective Cohort Study. [PDF]

PLoS ONE, 2015
The emergence of HIV-1 drug resistance mutations has mainly been linked to the duration and composition of antiretroviral treatment (ART), as well as the level of adherence.
Andargachew Mulu, Melanie Maier, Uwe Gerd Liebert   +2 more
doaj   +1 more source

Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs

Molecules, 2019
HIV protease inhibitors against the viral protease are often hampered by drug resistance mutations in protease and in the viral substrate Gag. To overcome this drug resistance and inhibit viral maturation, targeting Gag alongside protease rather than ...
Chinh Tran-To Su, Darius Wen-Shuo Koh, Samuel Ken-En Gan   +2 more
doaj   +1 more source

Naturally Occurring Mutations in HIV-1 Protease Gene Among People Living With HIV

Acta Medica Iranica, 2023
The emergence of resistance to antiretroviral drugs is the main problem in their long-term efficacy and by considering the wide use of protease inhibitors (PIs), monitoring drug resistance mutations is necessary.
Zahra Hasanshahi, Ava Hashempour, Javad Moayedi, Zahra Musavi, Behzad Rezaei, Behzad Dehghani, Farzaneh Ghassabi   +6 more
doaj   +1 more source

Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]

, 2013
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack, Crampin, Amelia C., Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, Ram K Shrestha, Travers, Simon A, Simon A Travers, French, Neil, Glynn, Judith R, Crampin, Amelia C, Vijay Bansode, Judith R Glynn, Vijay Bansode, Amelia C Crampin, McCormack, Grace P, Travers, Simon A., Shrestha, Ram K., Ngwira, Bagrey, Shrestha, Ram K, Bagrey Ngwira, Bansode Vijay, French Neil, Ngwira Bagrey, Crampin Amelia C, McCormack Grace P, Travers Simon A, Glynn Judith R, Shrestha Ram K   +29 more
core   +2 more sources

Drug resistance missense mutations in cancer are subject to evolutionary constraints.

PLoS ONE, 2013
Several tumour types are sensitive to deactivation of just one or very few genes that are constantly active in the cancer cells, a phenomenon that is termed 'oncogene addiction'.
Ran Friedman
doaj   +1 more source

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]

, 2014
This work was supported by grants from Breakthrough Breast Cancer and Scottish Funding Council (SRDG), and personal support to Alexey Goltsov from Scottish Informatics and Computer Science Alliance (SICSA) and to James Bown from The Northwood Trust.Drug ...
Bown, James, Goltsov, Alexey, Gregory Goltsov, Harrison, David J, Bown, J., Goltsov, Gregory, Simon P. Langdon, James eBown, Langdon, Simon P., Bown, James L., Langdon, S.P., Goltsov, G., Alexey eGoltsov, David eHarrison, Gregory eGoltsov, Alexey Goltsov, Harrison, D.J., Goltsov, A., Langdon, Simon P, David J. Harrison, Simon eLangdon, James Bown, Harrison, David J.   +22 more
core   +1 more source