Results 101 to 110 of about 2,749,589 (298)
Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling
Advanced Science, EarlyView.Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev +6 morewiley +1 more sourceAssociation between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese
, 2007 There is accumulating evidence to suggest that overexpression of efflux drug transporters at the blood-brain barrier, by reducing antiepileptic drug (AED) accumulation in the seizure foci, contributes to drug resistance in epilepsy.Hui, ACF, Wong, V, Baum, L, Lui, CH, Sin, NC, Yu, E, Ng, PW, Kwan, P, Wong, LKS +8 morecore +1 more sourceRemote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH
Advanced Science, EarlyView.Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo +14 morewiley +1 more sourceGenome-wide association meta-analyses of drug-resistant epilepsy [PDF]
Background
Epilepsy is one of the most common neurological disorders, affecting over 50 million people worldwide. One-third of people with epilepsy do not respond to currently available anti-seizure medications, constituting one of the most important ...Hoeper, Olivia, Taneja, Randip S., Francis, Ben, Leu, Costin, Schneider, Reinhard, Doherty, Colin P, Baumgartner, Tobias H, Demurtas, Rita, Todaro, Marian, Lowenstein, Daniel H, Krenn, Martin, Chinthapalli, Krishna, Krause, Roland, Lerche, Holger, Bisulli, Francesca, Meador, Kimford J., Tsai, Meng-Han, McCormack, Mark, Lal, Dennis, Unnsteinsdóttir, Unnur, Lin, Chih-Hsiang, Steinhoff, Bernhard J, Johnson, Michael R., Berghuis, Bianca, Andrade, Danielle M, Ferraro, Thomas N, Ryvlin, Philippe, Neale, Benjamin M, Pickrell, William O., Nikanorova, Marina, Lin, Kuang-Lin, Riva, Antonella, Zimprich, Fritz, Meador, Kimford J, Petrovski, Slavé, Lauxmann, Stephan, Castellotti, Barbara, Mayer, Thomas, Marson, Anthony G., Borggräfe, Ingo, Lowenstein, Daniel H., Pendziwiat, Manuela, Wagner, Ryan G, Lewis-Smith, David, Jorgensen, Andrea L., Brodie, Martin J, Müller-Schlüter, Karen, Ellis, Colin A, Striano, Pasquale, Ellis, Colin A., Scheffer, Ingrid E, Cotsapas, Chris, Weber, Yvonne G, Stevelink, Remi, Maillard, Louis, Suzuki, Toshimitsu, Lui, Colin H. T., Sammarra, Ilaria, Balagura, Ganna, Ali, Quratulain Zulfiqar, Madia, Francesca, Stefansson, Hreinn, Busch, Robyn M., Doccini, Viola, O'Brien, Terence J, Minardi, Raffaella, Lui, Colin H.T., Kunz, Wolfram S, Custodio, Helena Martins, Ragona, Francesca, Papacostas, Savvas S, Hirose, Shinichi, Fitzgerald, Mark, Craig, John J, Jonsson, Lina, Scala, Marcello, Sisodiya, Sanjay M, Neale, Benjamin M., Zahnert, Felix, Kousiappa, Ioanna, Neubauer, Bernd A., McGraw, Christopher M., Lacey, Austin, Kuzniecky, Ruben I., Sadleir, Lynette G, Langley, Sarah R, Hung, Po-Chen, Schubert-Bast, Susanne, Haas, Kevin, Salmon, Andrea, Baumgartner, Tobias H., von Wrede, Randi, Balling, Rudi, Powell, Robert HW, Gudmundsson, Lárus J, Magri, Stefania, Goldman, Alica, Rees, Mark I, Kuzniecky, Ruben I, Morris, Andrew, Andrade, Danielle M., Sander, Josemir W., Parrini, Elena, Speed, Doug, Chung, Seo-Kyung, Busch, Robyn M, Barba, Carmen, Campbell, Ellen, Chen, Siwei, Klein, Karl M, Tumiene, Birute, Berkovic, Samuel F., Dlugos, Dennis J., Salman, Bar??, Bennett, Caitlin A., Jorgensen, Andrea, Gagliardi, Monica, Sander, Josemir W, French, Jacqueline A, Wiebe, Samuel, Salman, Barış, Johnson, Michael R, Papacostas, Savvas S., Weckhuysen, Sarah, Auce, Pauls, Cavalleri, Gianpiero L, Hutton, Jane L., Marques, Paula, Nasreddine, Wassim, Gudmundsson, Lárus J., Powell, Robert H. W., Møller, Rikke S., Shiedley, Beth R, Hassanin, Emadeldin, Brodie, Martin J., Stefansson, Kari, Craig, John J., Yapıcı, Zuhal, Khoueiry-Zgheib, Nathalie, French, Jacqueline A., Neubauer, Bernd A, Labate, Angelo, Sadleir, Lynette G., Strzelczyk, Adam, Khoury, Jean, McGraw, Christopher M, Widdess-Walsh, Peter, Devinsky, Orrin, Srivastava, Prashant K, Granata, Tiziana, Stephani, Ulrich, Rener-Primec, Zvonka, Weber, Yvonne G., Mei, Davide, Turkdogan, Dilsad, Barboza, Karen, Jorgensen, Andrea L, Rheims, Sylvain, Balestrini, Simona, Baykan, Betül, Beydoun, Ahmad, Yamakawa, Kazuhiro, Surges, Rainer, Sperling, Michael R, Taneja, Randip S, Bosselmann, Christian, Rees, Mark I., Delanty, Norman, Amadori, Elisabetta, Shiedley, Beth R., Zara, Federico, Kwan, Patrick, Avbersek, Andreja, Annesi, Grazia, Klein, Karl M., Rau, Sarah, Bennett, Caitlin A, Scheffer, Ingrid E., Rosenow, Felix, Omidvar, Maryam Erfanian, Liao, Calwing, Zizovic, Milena, Schulze-Bonhage, Andreas, Zsurka, Gábor, Muccioli, Lorenzo, Hengsbach, Christian, Borghei, Mojgansadat, May, Patrick, Talarico, Mariagrazia, Langley, Sarah R., Hutton, Jane L, O'Brien, Terence J., van Baalen, Andreas, Gambardella, Antonio, Knake, Susanne, Craig, John, Koeleman, Bobby PC, Steinhoff, Bernhard J., Manna, Lorella, Vetro, Annalisa, Coppola, Antonietta, Yap?c?, Zuhal, Evans, Meghan, Freri, Elena, Marson, Anthony G, El-Naggar, Hany, Tanteles, George A, Lawthom, Charlotte, Doherty, Colin P., Sills, Graeme J., Sargsyan, Narek, Muhle, Hiltrud, Cavalleri, Gianpiero L., Berkovic, Samuel F, Lui, Colin HT, Koeleman, Bobby P. C., Srivastava, Prashant K., Sperling, Michael R., Willis, Joseph, Fortunato, Francesco, Powell, Robert H.W., Ingason, Andrés, Pickrell, William O, Koeleman, Bobby P.C., Becker, Felicitas, Canafoglia, Laura, Wolking, Stefan, Tanteles, George A., Depondt, Chantal, Sills, Graeme J, Wagner, Ryan G., Sisodiya, Sanjay M., Linnankivi, Tarja, Bebek, Nerses, Valton, Luc, Dlugos, Dennis J, Mostacci, Barbara, Chou, I-Jun, Ferraro, Thomas N., Gupta, Namrata, Klein, Karl Martin, Heggeli, Kristin, Kunz, Wolfram S., Koupparis, Andreas, Møller, Rikke S, Langley S. R., Hassanin E., McCormack M., Balestrini S., Scala M., Fortunato F., Striano P., Lui C. H. T., Mei D., Heggeli K., McGraw C. M., Rheims S., Berghuis B., Brodie M. J., Epi25 Collaborative, Petrovski S., Krause R., Gambardella A., Yap\u131c\u131, Zuhal, Chou I. -J., Stefansson K., Meador K. J., Nasreddine W., Rosenow F., Marson A. G., Muller-Schluter K., Pendziwiat M., Gudmundsson, L\ue1rus J., Sammarra I., Stef\ue1nsson, K\ue1ri, Lal D., Vetro A., Widdess-Walsh P., Steinhoff B. J., Jorgensen A. L., Devinsky O., Linnankivi T., Srivastava P. K., Kwan P., Kunz W. S., Custodio H. M., Maillard L., Surges R., Hutton J. L., Labate A., Chen S., Hoeper O., Marson, Anthony, Barba C., Baykan, Bet\ufcl, Wagner R. G., Ingason, Andr\ue9s, Collaborative, Epi25, El-Naggar H., Busch R. M., Zizovic M., Castellotti B., Koeleman, Bobby P C, Baykan B., Craig J., Weber Y. G., Becker F., Jorgensen A., Tanteles G. A., M\ufcller-Schl\ufcter, Karen, Nikanorova M., Balagura G., Valton L., O\u27Brien, Terence J, Berkovic, Samuel, Willis J., Salmon A., Borggr\ue4fe, Ingo, Turkdogan D., Auce P., Omidvar M. E., Ingason A., Beydoun A., Freri E., Powell R. H. W., Sander, Josemir, Bosselmann C., Mostacci B., Zimprich F., Lin K. -L., Cotsapas C., Bebek N., French J. A., Sisodiya S. M., Lawthom C., Khoueiry-Zgheib N., Martins Custodio, Helena, Haas K., Neale, Benjamin, Talarico M., Zara F., Coppola A., Yamakawa K., Petrovski, Slav\ue9, Stevelink R., Delanty N., Rees M. I., Zsurka G., Sadleir L. G., Stefansson H., Doccini V., Rau S., Kuzniecky R. I., Tsai M. -H., Lewis-Smith D., Gupta N., Sander J. W., Manna L., Lerche H., Papacostas S. S., Khoury J., Zahnert F., Sargsyan N., Riva A., Weckhuysen S., Borghei M., Canafoglia L., O'brien, Terence, Gudmundsson L. J., May P., Koeleman, Bobby, Hengsbach C., Unnsteinsd\uf3ttir, Unnur, Andrade D. M., Wiebe S., Lacey A., Parrini E., Omidvar, Maryam, Ferraro T. N., Suzuki T., Baumgartner T. H., Muccioli L., Taneja R. S., Marques P., Jonsson L., Koeleman B. P. C., Mayer T., Bennett, Caitlin, Ryvlin P., Morris A., Muhle H., Depondt C., Barboza K., Salman B., Craig J. J., Fitzgerald M., Campbell E., Borggrafe I., Pickrell W. O., van Baalen A., O'Brien T. J., Krenn M., Francis B., Stephani U., Ali Q. Z., Madia F., Liao C., Koupparis A., Cavalleri G. L., Yapici Z., Wolking S., Strzelczyk A., Knake S., Schulze-Bonhage A., Magri S., von Wrede R., Schubert-Bast S., Neale B. M., Bisulli F., Sisodiya, Sanjay, Moller R. S., Schneider R., Demurtas R., Sisodiyab, Sanjay M, Sperling M. R., Johnson, Michael, Lin C. -H., Annesi G., Hirose S., Gagliardi M., Doherty C. P., Tumiene B., Rener-Primec Z., Berkovic S. F., Hung P. -C., Shiedley B. R., Chung S. -K., O'Brien, Terence J, Unnsteinsdottir U., Lowenstein D. H., Granata T., Goldman A., Evans M., Leu C., Ragona F., Zsurka, G\ue1bor, Balling R., The Epi25 Collaborative, [Study group], EpiPGX Consortium, Cavalleri, Gianpiero, Bennett C. A., Scheffer I. E., Avbersek A., Ellis C. A., Salman, Bar\u131\u15f, Kousiappa I., Speed D., Klein K. M., Sills G. J., Lauxmann S., Amadori E., Dlugos D. J., Johnson M. R., Sills, Graeme, Chinthapalli K., Todaro M., Neubauer B. A., M\uf8ller, Rikke S., Consortium, Epipgx, Minardi R., Lingason L. +470 morecore +4 more sourcesLanguage recovery after epilepsy surgery of the Broca's area
Epilepsy and Behavior Case Reports, 2018 Epilepsy surgery is indicated in select patients with drug-resistant focal epilepsy. Seizure freedom or significant reduction of seizure burden without risking new neurological deficits is the expected goal of epilepsy surgery.Lilit Mnatsakanyan, Sumeet Vadera, Christopher W. Ingalls, Jie Zheng, Mona Sazgar, Frank P. Hsu, Jack J. Lin +6 moredoaj +1 more sourceLactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer
Advanced Science, EarlyView.Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu +11 morewiley +1 more source[Drug-resistant epilepsy].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2009 Despite the introduction of many new antiepileptic drugs during recent years, about one third of the epilepsy population continue to have drug-resistant seizures. We present two hypotheses on mechanisms of drug-resistant epileptic seizures.The article is based on our own clinical experience and literature identified through a PubMed search using the ...Karl O, Nakken, Erik, Taubøllopenaire +1 more source
