Results 101 to 110 of about 366,264 (296)
Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]
, 2014 Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core +1 more source
Effect and tolerability of perampanel in patients with drug-resistant epilepsy.
Epilepsy & Behavior, 2021 OBJECTIVE Perampanel is one of the most recently approved antiseizure medications. The aim of the present study was to assess clinical efficacy and tolerability, in combination with pharmacokinetic variability, of perampanel treatment in patients at a ...
Ida Marie Bakke Lossius +6 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source
Quality in SportIntroduction and objective Drug-resistant epilepsy (DRE) is a type of epilepsy where seizures persist despite treatment with multiple antiepileptic drugs being implemented.
Robert Rzenno +9 more
doaj +1 more source
Current approaches to neurosurgical treatment for drug-resistant focal epilepsy in adults
Неврология, нейропсихиатрия, психосоматика, 2018 The review is dedicated to the problems of current neurosurgical treatment for drug-resistant epilepsy in the adult population of Russia and foreign countries. The literature published in the period 2010–2017 was sought in Russian and foreign databases.
E. A. Narodova +4 more
doaj +1 more source
Evaluation of perampanel as monotherapy for focal seizures: Experience from open-label extension studies [PDF]
, 2017 Perampanel, a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, is approved for adjunctive treatment of focal seizures, with or without secondarily generalized seizures, and for primary ...
Cartwright, Karen +5 more
core +1 more source
White Matter Abnormalities in Patients with Treatment-Resistant Genetic Generalized Epilepsies. [PDF]
, 2016 BACKGROUND Genetic generalized epilepsies (GGEs) are associated with microstructural brain abnormalities that can be evaluated with diffusion tensor imaging (DTI). Available studies on GGEs have conflicting results.
Allendorfer, Jane B +7 more
core +2 more sources
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
Incidence and prevalence of major epilepsy-associated brain lesions
Epilepsy & Behavior Reports, 2022 Epilepsy surgery is an effective treatment option for drug-resistant focal epilepsy patients with associated structural brain lesions. However, little epidemiological data are available regarding the number of patients with these lesions.
Javier A. López-Rivera +11 more
doaj +1 more source
Getting the best outcomes from epilepsy surgery. [PDF]
, 2018 Neurosurgery is an underutilized treatment that can potentially cure drug-refractory epilepsy. Careful, multidisciplinary presurgical evaluation is vital for selecting patients and to ensure optimal outcomes.
Duncan, John S +5 more
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