Results 81 to 90 of about 2,582,033 (201)

Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy

The Journal of Clinical Investigation
The histopathological neurons in the brain tissue of drug-resistant epilepsy exhibit aberrant cytoarchitecture and imbalanced synaptic circuit function.
Qianqian Ge, Jiachao Yang, Fei Huang, Xinyue Dai, Chao Chen, Jingxin Guo, Mi Wang, Mengyue Zhu, Yijie Shao, Yuxian Xia, Yu Zhou, Jieqiao Peng, Suixin Deng, Jiachen Shi, Yiqi Hu, Huiying Zhang, Yi Wang, Xiaoqun Wang, Xiao-Ming Li, Zhong Chen, Yousheng Shu, Jun-Ming Zhu, Jianmin Zhang, Ying Shen, Shumin Duan, Shengjin Xu, Li Shen, Jiadong Chen   +27 more
doaj   +1 more source

Neuroimaging abnormalities in pediatric drug-resistant epilepsy

Alexandria Journal of Medicine
Background One of the most prevalent neurological conditions in the world is epilepsy. With over 90% of all newly diagnosed cases occurring in young persons aged 20 and under, epilepsy disproportionately affects children.
Samar Almestkawy, Hanan Galal Azouz, Tarek Omar, Omneya Attallah, Shimaa A.M. Anwar   +4 more
doaj   +1 more source

Drug resistant epilepsy as the consequence of inadequate control of type 1 diabetes

Hypoglycemic encephalopathy (HE) is a type of encephalopathy resulting from extremely low blood glucose level. Symptoms are not specific and can be misdiagnosed very often.
Maria Mazurkiewicz-Bełdzińska, Marta Zawadzka, Natalia Omieczyńska, Ewa M. Sokolewicz, Kamil Dzwilewski   +4 more
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Language recovery after epilepsy surgery of the Broca's area

Epilepsy and Behavior Case Reports, 2018
Epilepsy surgery is indicated in select patients with drug-resistant focal epilepsy. Seizure freedom or significant reduction of seizure burden without risking new neurological deficits is the expected goal of epilepsy surgery.
Lilit Mnatsakanyan, Sumeet Vadera, Christopher W. Ingalls, Jie Zheng, Mona Sazgar, Frank P. Hsu, Jack J. Lin   +6 more
doaj   +1 more source

Study on expressions of heat shock 27⁃associated protein 1 and echinoderm microtubule⁃associated protein⁃like 5 in drug⁃resistant epilepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective To observe the expressions of heat shock 27 ⁃ associated protein 1 (HSPBAP1) and echinoderm microtubule⁃associated protein⁃like 5 (EML5) in cerebrospinal fluid of drug⁃ resistant epilepsy, and to explore the value in early diagnosis of epilepsy.
Yun CHEN, Zhi⁃qin XI, Zhen⁃li GUO, Hong⁃xiang YIN, Bin FU, Rui ZHOU, Bi⁃tang DAN   +6 more
doaj  

Diagnosis and Surgical Treatment of Drug-Resistant Epilepsy

Brain Sciences, 2018
Despite appropriate trials of at least two antiepileptic drugs, about a third of patients with epilepsy remain drug resistant (intractable; refractory).
Chinekwu Anyanwu, Gholam K. Motamedi
doaj   +1 more source

[Drug-resistant epilepsy].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2009
Despite the introduction of many new antiepileptic drugs during recent years, about one third of the epilepsy population continue to have drug-resistant seizures. We present two hypotheses on mechanisms of drug-resistant epileptic seizures.The article is based on our own clinical experience and literature identified through a PubMed search using the ...
Karl O, Nakken, Erik, Taubøll
openaire   +1 more source

Benzodiazepine-resistant epilepsy: unraveling molecular mechanisms and developing multimodal therapeutic strategies

Frontiers in Neurology
Epilepsy is one of the most common nervous system diseases, which is characterized by recurrent seizures caused by abnormal neuronal discharges in the brain. Drug-resistant epilepsy (DRE) brings great challenges to clinical treatment.
Yanqiu Huang, Yangfan Zhang, Yi Liang
doaj   +1 more source

Second‐hit DEPDC5 mutation is limited to dysmorphic neurons in cortical dysplasia type IIA

Annals of Clinical and Translational Neurology, 2019
Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy and is associated with pathogenic variants in mTOR pathway genes. How germline variants cause these focal lesions is unclear, however a germline + somatic “2‐hit” model is hypothesized.
Wei Shern Lee, Sarah E. M. Stephenson, Katherine B. Howell, Kate Pope, Greta Gillies, Alison Wray, Wirginia Maixner, Simone A. Mandelstam, Samuel F. Berkovic, Ingrid E. Scheffer, Duncan MacGregor, Anthony Simon Harvey, Paul J. Lockhart, Richard J. Leventer   +13 more
doaj   +1 more source

Report of the 2003 National Conference on Public Health and Epilepsy [PDF]

I. Executive Summary -- II. Introduction -- III. Living Well with Epilepsy II Conference -- -- IV. Review and Recommendations -- -- Workgroup A: Early Recognition, Diagnosis and Treatment -- -- Workgroup B: Epidemiology and Surveillance -- -- Workgroup C:
National Conference on Public Health and Epilepsy (2003 : Baltimore, MD)
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