Results 81 to 90 of about 366,264 (296)

High‐mobility group box 1 as a predictive biomarker for drug‐resistant epilepsy: A proof‐of‐concept study

open access: yesEpilepsia, 2021
Currently no sensitive and specific biomarkers exist to predict drug‐resistant epilepsy. We determined whether blood levels of high‐mobility group box 1 (HMGB1), a mediator of neuroinflammation implicated in drug‐resistant epilepsies, identifies patients
L. Walker   +8 more
semanticscholar   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu   +11 more
wiley   +1 more source

Clinical diagnostic features and surgical outcomes of mesial temporal lobe epilepsy

open access: yesВестник хирургии имени И.И. Грекова, 2023
Despite certain successes in the treatment of epilepsy, primarily associated with the active development of pharmacology, in 30% of cases, there is a resistant course, especially focal forms of temporal lobe epilepsy.
O. P. Subbotina   +2 more
doaj   +1 more source

Definitions of Drug-Resistant Epilepsy for Administrative Claims Data Research

open access: yesNeurology, 2021
Background and Objective To assess the accuracy of definitions of drug-resistant epilepsy applied to administrative claims data. Methods We randomly sampled 450 patients from a tertiary health system with ≥1 epilepsy/convulsion encounter, ≥2 distinct ...
C. Hill   +6 more
semanticscholar   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

EVALUATION OF THE PSYCHOLOGICAL INTERVENTION PROGRAM APPLIED TO PEOPLE WITH DRUG-RESISTANT EPILEPSY [PDF]

open access: yesPsihologie
Drug-resistant epilepsy presents a myriad of psychological challenges, including cognitive decline, emotional and behavioral disturbances, loss of autonomy, stigma, psychosocial dysfunction, and a heightened risk of trauma and premature death, all of ...
DOȚEN Natalia
doaj   +1 more source

Efficacy of modified atkins ketogenic diet in chronic cluster headache. An open-label, single-arm, clinical trial [PDF]

open access: yes, 2018
Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine.
Cherubino Di Lorenzo   +9 more
core   +3 more sources

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye   +11 more
wiley   +1 more source

Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy

open access: yesEpilepsy and Behavior Case Reports, 2018
Responsive neurostimulation for epilepsy involves an implanted device that delivers direct electrical brain stimulation in response to detection of incipient seizures.
Nilika S. Singhal   +6 more
doaj   +1 more source

Pregabalin Add-On vs. Dose Increase in Levetiracetam Add-On Treatment: A Real-Life Trial in Dogs With Drug-Resistant Epilepsy

open access: yesFrontiers in Veterinary Science, 2022
Epilepsy is a common neurological disorder affecting 0.6–0.75% of dogs in veterinary practice. Treatment is frequently complicated by the occurrence of drug-resistant epilepsy and cluster seizures in dogs with idiopathic epilepsy.
Sandra R. P. Kriechbaumer   +12 more
doaj   +1 more source

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