The prevalence of drug-resistant-epilepsy and its associated factors in patients with epilepsy.
Clinical neurology and neurosurgery (Dutch-Flemish ed. Print), 2021 BACKGROUND Drug-resistant epilepsy (DRE) is a major challenge in patients with epilepsy. The majority of previous studies evaluating the risk factors of DRE have been conducted in children. Therefore, this study aimed to investigate the prevalence of DRE
P. Mohammadzadeh, S. Nazarbaghi
semanticscholar +1 more source
Frontiers in NeurologyAn increasing number of gene mutations associated with epilepsy have been identified, some linked to gray matter heterotopia—a common cause of drug-resistant epilepsy.
Zijian Li +5 more
doaj +1 more source
The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs [PDF]
, 2019 Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary.
Dag, Ramazan +4 more
core +1 more source
Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy [PDF]
Brain, 2002 Epilepsy is resistant to drug treatment in about one-third of cases, but the mechanisms underlying this drug resistance are not understood. In cancer, drug resistance has been studied extensively. Amongst the various resistance mechanisms, overexpression of drug resistance proteins, such as multi-drug resistance gene-1 P-glycoprotein (MDR1) and ...
S M, Sisodiya +4 more
openaire +2 more sources
Evaluation of Risk Factors for Epilepsy in Pediatric Patients with Cerebral Palsy
Brain Sciences, 2020 Cerebral palsy (CP) is a set of etiologically diverse symptoms that change with the child’s age. It is one of the most frequent causes of motor disability in children. CP occurs at a frequency of 1.5 to 3.0 per 1000 live-born children.
Małgorzata Sadowska +2 more
doaj +1 more source
Cost-Effectiveness of Advanced Imaging Technologies in the Presurgical Workup of Epilepsy. [PDF]
, 2020 The cost-effectiveness and benefit of many diagnostic tests used in the presurgical evaluation for persons with epilepsy is for the most part uncertain as is their influence on decision-making.
Chang, Edward F +2 more
core
Increased expression of matrix metalloproteinase-9 in patients with temporal lobe epilepsy [PDF]
, 2014 Aim: The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited.
Acar, Feridun +3 more
core +1 more source
Clinical predictors of drug-resistant epilepsy in children
Turkish Journal of Medical Sciences, 2021 Background/aim In up to 20% of epilepsy patients, seizures may not be controlled despite the use of antiepileptic drugs, either alone or in combination. These individuals are considered to have drug-resistant epilepsy.
P. Karaoğlu +4 more
semanticscholar +1 more source
Drug-Resistant Juvenile Myoclonic Epilepsy: Misdiagnosis of Progressive Myoclonus Epilepsy [PDF]
Frontiers in Neurology, 2019 Juvenile myoclonic epilepsy (JME) is a common epilepsy syndrome characterized by bilateral myoclonic and tonic-clonic seizures typically starting in adolescence and responding well to medication. Misdiagnosis of a more severe progressive myoclonus epilepsy (PME) as JME has been suggested as a cause of drug-resistance.
Sarah Martin +23 more
openaire +5 more sources
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source