Results 71 to 80 of about 2,582,033 (201)

Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy

Epilepsia Open
Objective Subcortical nuclei such as the thalamus and striatum have been shown to be related to seizure modulation and termination, especially in drug‐resistant epilepsy.
Guixian Tang, Hailing Zhou, Chunyuan Zeng, Yuanfang Jiang, Ying Li, Lu Hou, Kai Liao, Zhiqiang Tan, Huanhua Wu, Yongjin Tang, Yong Cheng, Xueying Ling, Qiang Guo, Hao Xu   +13 more
doaj   +1 more source

Deep brain stimulation in drug-resistant epilepsy: current status and future perspectives

Chinese Journal of Contemporary Neurology and Neurosurgery
Drug-resistant epilepsy remains a major challenge in management of epilepsy, with approximately half of patients being unsuitable candidates for resective surgery.
HU Tian-qi, XIE Hu-tao, ZHANG Jian-guo
doaj   +1 more source

Antiepileptic Drug Therapy in Patients with Drug-Resistant Epilepsy [PDF]

Journal of Epilepsy Research, 2019
Antiepileptic drug (AED) therapy starts with an accurate diagnosis of epilepsy and is followed by sequential drug trials. Seizure freedom is largely achieved by the first two drug trials; thus, epilepsy that cannot be controlled after appropriately conducted trials of the first two drugs is defined as drug-resistant epilepsy (DRE).
Park, Kang Min, Kim, Sung Eun, Lee, Byung In   +2 more
openaire   +2 more sources

Current Principles in the Management of Drug-Resistant Epilepsy [PDF]

, 2022
Drug-resistant epilepsy is associated with poor health outcomes and increased economic burden. In the last three decades, various new antiseizure medications have been developed, but the proportion of people with drug-resistant epilepsy remains ...
Shlobin, Nathan, Sander, Josemir
core   +1 more source

Six adult patients with septo-optic dysplasia and drug-resistant epilepsy: Clinical findings and course

Epilepsy and Behavior Case Reports, 2017
Septo-optic dysplasia (SOD) is a rare disorder associated with optic nerve hypoplasia, pituitary abnormalities and agenesis/dysgenesis of midline brain structures including the septum pellucidum and corpus callosum.
Mashael AlKhateeb, Richard McLachlan, Jorge Burneo, David Diosy, Seyed Mirsattari   +4 more
doaj   +1 more source

Genetic Analysis of Sodium Channel Genes in Pediatric Epilepsy Patients of Pakistan

Genetics Research, 2022
Epilepsy affects millions of people worldwide. Although antiepileptic drugs work for the majority of epileptic patients, these drugs do not work for some of the patients, subjecting them to drug-resistant epilepsy (DRE). Voltage-gated sodium channels act
Aqsa Ashfaq, Tayyaba Saleem, Nadeem Sheikh, Hafsa Maqbool   +3 more
doaj   +1 more source

Modulation of calcium and potassium currents by lamotrigine [PDF]

, 1998
Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CAI and CA3 pyramidal cells in vitro.
Greene, Robert, Wegerer, Jörg von, Greene, Robert W., Grunze, Heinz, Walden, Jörg, Jörg Walden, Heinz Grunze, Robert Greene, Jörg von Wegerer   +8 more
core   +1 more source

Analysis of Patients with Focal Epilepsy and Drug-Resistant Epilepsy in Italy: Evaluation of Their Characteristics, Therapeutic Pathway and the Consumption of Healthcare Resources

, 2022
Valentina Perrone,1 Chiara Veronesi,1 Melania Dovizio,1 Domenica Daniela Ancona,2 Margherita Andretta,3 Fausto Bartolini,4 Arturo Cavaliere,5 Alessandro Chinellato,6 Andrea Ciaccia,7 Mariarosaria Cillo,8 Adele De Francesco,9 Nicola Enieri,6 Fulvio ...
Ciaccia A, Veronesi C, Vercellone A, Cillo M, De Francesco A, Ferrante F, Bartolini F, Dovizio M, Cavaliere A, Ubertazzo L, Perrone V, Procaccini M, Enieri N, Gentile S, Lucatelli D, Ancona DD, Chinellato A, Procacci C, Andretta M, Degli Esposti L   +19 more
core  

Clinical predictors of drug-resistant epilepsy in children

, 2021
Background/aim: In up to 20% of epilepsy patients, seizures may not be controlled despite the use of antiepileptic drugs, either alone or in combination. These individuals are considered to have drug-resistant epilepsy. Drug-resistant epilepsy is usually
YİŞ, ULUÇ, Polat, AYŞE İPEK, Ayanoglu, Muge, Karaoglu, Pakize, Hiz, Semra   +4 more
core   +1 more source

Drug‐resistant epilepsy and mortality—Why and when do neuromodulation and epilepsy surgery reduce overall mortality

, 2022
International audienceAbstract Patients with drug‐resistant epilepsy have an increased mortality rate, with the majority of deaths being epilepsy related and 40% due to sudden unexpected death in epilepsy (SUDEP).
Mickael R. Sperling, Sperling, M.R., Sperling, Mickael, Ryvlin, Philippe, Sylvain Rheims, Rheims, Sylvain, Ryvlin, P., Philippe Ryvlin, Rheims, S.   +8 more
core   +1 more source