Case Report: Early infantile drug-resistant epilepsy and gastrointestinal dysmotility associated with a <i>de novo GNAO1</i> variant and a 16p13.11 microdeletion. [PDF]
Liu X, Luo R, Wang J, Chen X, Deng Y.
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A Rare Genetic Disorder Presenting with Neuropsychiatric Involvement and Drug-Resistant Epilepsy: The First Adult Patient with Adenylosuccinate Lyase Deficiency in Türkiye. [PDF]
Altındağ E, Baykan B.
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Efficacy and Safety of Adjunctive Perampanel in Young Children (7-46 Months) With Drug-Resistant Epilepsy: A Real-World Study. [PDF]
Zeng Q +5 more
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Localizing the epileptogenic zone in drug-resistant epilepsy based on ictal SEEG high-resolution time-frequency representation. [PDF]
Fu G +6 more
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Correction: Precision management of cenobamate in drug-resistant epilepsy: integrating pharmacogenetics, therapeutic drug monitoring, and real-world clinical strategies. [PDF]
d'Orsi G +14 more
europepmc +1 more source
Resting-State fMRI Functional Connectivity Alterations in Drug-Resistant Epilepsy Compared to Well-Controlled Epilepsy and Healthy Controls. [PDF]
Vasilev P +6 more
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Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
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Nearly a quarter of patients with seizures have drug-resistant epilepsy. This review examines how this diagnosis should be established and how to recognize pseudoresistance. It explains possible mechanisms of drug-resistant epilepsy and presents treatment strategies.
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Mechanisms of Apoptosis in Drug-Resistant Epilepsy
Neuroscience and Behavioral Physiology, 2022Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune and neurodegenerative processes. Approximately 40% of patients suffer from drug-resistant epilepsy, which leads to an increased risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced ...
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