Results 171 to 180 of about 2,582,033 (201)

Surgical treatment of drug-resistant epilepsy

Burdenko's Journal of Neurosurgery
Background. Surgical treatment is possible for drug-resistant epilepsy. Localization of epileptogenic zone in temporal lobe or outside it influences the effectiveness of surgical treatment. Objective. To evaluate the effectiveness of surgical treatment of drug-resistant epilepsy. Material and methods.
A.A. Zuev, N.V. Pedyash, N.P. Utyashev, N.O. Ivin, A.A. Utyasheva, E.A. Gordeeva   +5 more
openaire   +2 more sources

Drug resistance in epilepsy: human epilepsy.

Novartis Foundation symposium, 2002
The basis of drug resistance in human epilepsy is not understood. Parallels with resistance in cancer suggest that drug resistance proteins may have a role. To examine this possibility, we have studied human brain tissue containing pathologies capable of causing refractory epilepsy.
S M, Sisodiya, W R, Lint, B N, Harding, M V, Squier, M, Thom   +4 more
openaire   +1 more source

Update on Cannabidiol in Drug-Resistant Epilepsy

Indian Journal of Pediatrics
Cannabidiol (CBD) has arisen as a promising therapeutic option for children with drug-resistant epilepsy (DRE). CBD has received regulatory nod from different regulatory authorities in the United States, Europe, and India for children with DRE particularly, Dravet syndrome (DS), Lennox Gastaut syndrome (LGS), and Tuberous sclerosis complex (TSC ...
Akanksha Singh, Priyanka Madaan, Dipika Bansal   +2 more
openaire   +2 more sources

Resective Epilepsy Surgery for Drug-Resistant Focal Epilepsy

JAMA, 2015
Epilepsy surgery is indicated for patients with focal seizures who do not respond to appropriate antiepileptic drug therapy consisting of 2 or more medications.To review resective surgery outcomes for focal epilepsy, to identify which patients benefit the most, and to discuss why epilepsy surgery may not be universally accepted.Medline and Cochrane ...
Barbara C, Jobst, Gregory D, Cascino
openaire   +2 more sources

Neuromodulation for the Treatment of Drug-Resistant Epilepsy

2014
Surgical neuromodulation for epilepsy refers to procedures involving the electrical stimulation of cortical, diencephalic, cerebellar and peripheral targets (such as the vagus nerve). Stereotactic radiosurgery also provides a neuromodulatory approach, affecting the discharging behavior of epileptic neurons in absence of evident target necrosis ...
Romanelli, Pantaleo, Conti, Alfredo
openaire   +3 more sources

Perampanel: A Review in Drug-Resistant Epilepsy

Drugs, 2015
Perampanel (Fycompa®), an orally-active, selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, is a first-in-class antiepileptic drug (AED) offering the convenience of once-daily administration. In the EU and US, perampanel is approved in patients with epilepsy aged ≥12 years for the adjunctive ...
openaire   +2 more sources

Animal models of drug‐resistant epilepsy^*

Epileptic Disorders, 2012
ABSTRACTSeveral animal models are discussed in order to outline features of difficult‐to‐treat or drug‐resistant epilepsy. These models can be categorised as those which show a poor response to different antiepileptic drugs and those in which subgroups of drug‐resistant animals are selected, based on interindividual differences.
openaire   +2 more sources

Drug-Resistant Epilepsy

2021
Susanna O’Kula, Michael Gelfand
openaire   +1 more source

Interneuron Transplantation for Drug-Resistant Epilepsy

Neurosurgery Clinics of North America
Current epilepsy surgical techniques, such as brain resection, laser ablation, and neurostimulation, target seizure networks macroscopically, and they may yield an unfavorable balance between seizure reduction, procedural invasiveness, and neurologic morbidity.
openaire   +2 more sources

Clinical Management of Drug Resistant Epilepsy: A Review on Current Strategies

Neuropsychiatric Disease and Treatment, 2021
Deborah Guery, Sylvain Rheims
exaly