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Drug-resistant epilepsy: Definition, pathophysiology, and management.
Journal of Neurological Sciences, 2023There are currently >51 million people with epilepsy (PWE) in the world and every year >4.9 million people develop new-onset epilepsy. The cornerstone of treatment in PWE is drug therapy with antiseizure medications (ASMs).
B. Mesraoua +5 more
semanticscholar +1 more source
The Lancet Neurology, 2023
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
openaire +2 more sources
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other factors such as age of seizure onset and presence of associated neurological deficits.
Emilio Perucca +3 more
openaire +2 more sources
JAMA pediatrics, 2023
Importance Despite advances in the understanding of dietary therapies in children with drug-resistant epilepsy, no quantitative comparison exists between different dietary interventions.
N. Devi +4 more
semanticscholar +1 more source
Importance Despite advances in the understanding of dietary therapies in children with drug-resistant epilepsy, no quantitative comparison exists between different dietary interventions.
N. Devi +4 more
semanticscholar +1 more source
Epilepsia, 2023
Despite progress in the development of anti‐seizure medications (ASMs), one third of people with epilepsy have drug‐resistant epilepsy (DRE). The working definition of DRE, proposed by the International League Against Epilepsy (ILAE) in 2010, helped ...
S. Auvin +5 more
semanticscholar +1 more source
Despite progress in the development of anti‐seizure medications (ASMs), one third of people with epilepsy have drug‐resistant epilepsy (DRE). The working definition of DRE, proposed by the International League Against Epilepsy (ILAE) in 2010, helped ...
S. Auvin +5 more
semanticscholar +1 more source
Centromedian thalamic deep brain stimulation for drug-resistant epilepsy: single-center experience.
Journal of Neurosurgery, 2022OBJECTIVE Neuromodulation of the centromedian nucleus of the thalamus (CM) has unclear effectiveness in the treatment of drug-resistant epilepsy. Prior reports suggest that it may be more effective in the generalized epilepsies such as Lennox-Gastaut ...
Jimmy C. Yang +6 more
semanticscholar +1 more source
Current and future pharmacotherapy options for drug-resistant epilepsy
Expert Opinion on Pharmacotherapy, 2022Introduction Epilepsy is a common neurological condition, affecting over 70 million individuals worldwide. Areas covered The present paper reviews current and future (under preclinical and clinical development) pharmacotherapy options for the treatment ...
S. Elkommos, M. Mula
semanticscholar +1 more source
Drug-resistant epilepsy at the age extremes: Disentangling the underlying etiology.
Epilepsy & Behavior, 2022The incidence of epilepsy is highest at the extreme age ranges: childhood and elderly age. The most common syndromes in these demographics - self-limited epilepsies of childhood and idiopathic generalized epilepsies in pediatric age, focal epilepsy with ...
E. Bartolini +4 more
semanticscholar +1 more source
Topiramate for drug-resistant epilepsies
European Journal of Paediatric Neurology, 2000Topiramate is a new anti-epileptic drug with proven efficacy against partial seizures in adults. A retrospective assessment of the use of topiramate in drug-resistant childhood epilepsy was undertaken. Thirty-four children (median age of 10 years; range 2-18 years) were treated for a median of 9 months (range 6-18 months).
S, Yeung +3 more
openaire +2 more sources
Epilepsy Research, 2021
BACKGROUND Approximately one-third of epilepsy patients suffer from drug-resistant epilepsy. The gut microbiome, which is the total genetic makeup of all of the total microbes inhabiting the gut, can affect the CNS through various mechanisms.
Hyemi Lee +3 more
semanticscholar +1 more source
BACKGROUND Approximately one-third of epilepsy patients suffer from drug-resistant epilepsy. The gut microbiome, which is the total genetic makeup of all of the total microbes inhabiting the gut, can affect the CNS through various mechanisms.
Hyemi Lee +3 more
semanticscholar +1 more source
Understanding drug-resistant epilepsy
British Journal of Neuroscience Nursing, 2021Despite the wide choice of antiseizure medications, drug-resistant epilepsy is common. Mark Greener introduces some ways in which researchers are trying to improve outcomes for people with drug-resistant epilepsy.
openaire +1 more source