Results 251 to 260 of about 366,264 (296)

Mechanisms of Apoptosis in Drug-Resistant Epilepsy

Neuroscience and Behavioral Physiology, 2022
Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune and neurodegenerative processes. Approximately 40% of patients suffer from drug-resistant epilepsy, which leads to an increased risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced ...
E.D. Bazhanova, A.A. Kozlov
openaire   +2 more sources

Efficacy of low glycemic index diet therapy (LGIT) in children aged 2-8 years with drug-resistant epilepsy: A randomized controlled trial.

Epilepsy Research, 2021
BACKGROUND A classic ketogenic diet, even though effective in children with drug-resistant epilepsy is not tolerated well by them and cumbersome to prepare.
K. Lakshminarayanan, A. Agarawal, P. Panda, R. Sinha, M. Tripathi, R. Pandey, S. Gulati   +6 more
semanticscholar   +1 more source

Evaluation and management of drug resistant epilepsy in children.

Current Problems in Pediatric and Adolescent Health Care, 2021
Epilepsy is one of the most common neurological conditions in children. Most children with epilepsy respond to anti- epileptic drugs (AEDs) but approximately 30% of children develop drug resistant epilepsy (DRE) defined as 'the failure of adequate trials
Gogi Kumar
semanticscholar   +1 more source

Vagus nerve stimulation for drug-resistant epilepsy induced by tuberous sclerosis complex.

Epilepsy & Behavior, 2021
OBJECTIVE This study investigated the dynamic and long-term efficacy of vagus nerve stimulation (VNS) in patients with drug-resistant epilepsy (DRE) induced by tuberous sclerosis complex (TSC).
Xuezhi Tong, Xiongfei Wang, Lan Qin, Jian Zhou, Y. Guan, P. Teng, Jing Wang, Yujiao Yang, Tianfu Li, G. Luan   +9 more
semanticscholar   +1 more source

Long-term effectiveness and adverse effects of ketogenic diet therapy in infants with drug-resistant epilepsy treated at a single center in Argentina.

Epilepsy Research, 2021
INTRODUCTION Ketogenic diet therapy (KDT) is a metabolic treatment with proven effectiveness for the treatment of drug-resistant epilepsy in children.
M. Armeno, Antonella Verini, E. Caballero, A. Cresta, G. Valenzuela, R. Caraballo   +5 more
semanticscholar   +1 more source

Management of Drug-Resistant Epilepsy

Continuum, 2016
This review discusses the definition, evaluation, and management of patients with drug-resistant epilepsy.Drug-resistant epilepsy is defined as a failure of two or more appropriately selected and adequately tried anticonvulsant medications to achieve seizure freedom for a sustained period of time in either monotherapy or polytherapy.
openaire   +2 more sources

Genetics of drug resistance in epilepsy

Current Neurology and Neuroscience Reports, 2005
Drug resistance is a major clinical problem in epilepsy, affecting one in three patients. It is likely to have a complex multifactorial basis, with environmental and genetic contributions. Knowledge of robust genetic factors underlying drug resistance might both improve prediction and permit the development of novel rational treatments for resistance ...
openaire   +2 more sources

Neuroimaging of drug resistance in epilepsy

Current Opinion in Neurology, 2014
Drug resistance is an important clinical problem: it is associated with higher rates of somatic and psychiatric comorbidities and cognitive/memory decline, with seizures being just the 'tip of the iceberg'. This review summarizes recent developments in imaging research, focusing specifically on the functional consequence of chronic epilepsies and ...
openaire   +2 more sources

Drug resistance in epilepsy: human epilepsy.

Novartis Foundation symposium, 2002
The basis of drug resistance in human epilepsy is not understood. Parallels with resistance in cancer suggest that drug resistance proteins may have a role. To examine this possibility, we have studied human brain tissue containing pathologies capable of causing refractory epilepsy.
S M, Sisodiya, W R, Lint, B N, Harding, M V, Squier, M, Thom   +4 more
openaire   +1 more source

Neuromodulation in pediatric drug-resistant epilepsy

Epilepsy & Behavior
This is a summary of the three commercially available neuromodulation devices for refractory epilepsy, highlighting their use in children. The article offers a high-level review of the proposed mechanisms of vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation, the pivotal trials leading to their approval for use in the ...
Ann, Hyslop, Marytery, Fajardo
openaire   +2 more sources