Results 11 to 20 of about 874,537 (314)
Deciphering the scopolamine challenge rat model by preclinical functional MRI
Scientific Reports, 2021 During preclinical drug testing, the systemic administration of scopolamine (SCO), a cholinergic antagonist, is widely used. However, it suffers important limitations, like non-specific behavioural effects partly due to its peripheral side-effects ...
Gergely Somogyi +5 more
doaj +1 more source
UnCorrupt SMILES: a novel approach to de novo design
Journal of Cheminformatics, 2023 Generative deep learning models have emerged as a powerful approach for de novo drug design as they aid researchers in finding new molecules with desired properties.
Linde Schoenmaker +3 more
doaj +1 more source
Skin Sensitization Potential and Cellular ROS-Induced Cytotoxicity of Silica Nanoparticles
Nanomaterials, 2021 Nowadays, various industries using nanomaterials are growing rapidly, and in particular, as the commercialization and use of nanomaterials increase in the cosmetic field, the possibility of exposure of nanomaterials to the skin of product producers and ...
Sung-Hyun Kim +7 more
doaj +1 more source
BMJ, 2005 EDITOR—Eaton reports that more surveillance of drugs is needed to protect the public.1 All drugs are dangerous, some may also be useful. If drug efficacy is easy to show, drug safety (low risk) is essentially unprovable: absence of demonstration of risk is not demonstration of absence.
openaire +2 more sources
BMC Cardiovascular Disorders, 2022 Background Recent studies have raised concern about the association of fluoroquinolones with an increased risk of aortic aneurysm and aortic dissection. We aimed to evaluate such risk in a Korean population.
Nayeong Son +4 more
doaj +1 more source
Applied Sciences, 2023 Even though synthetic colorants can cause side effects such as allergies and pigmentation, they have not been sufficiently researched. Herein, high-performance liquid chromatography, liquid chromatography-tandem mass spectrometry, and liquid ...
Kyoung-Moon Han +6 more
doaj +1 more source
Effect of Pulmonary Inflammation by Surface Functionalization of Zinc Oxide Nanoparticles
Toxics, 2021 Zinc oxide nanoparticles (ZnO NPs) are used in various industries such as food additives, cosmetics, and biomedical applications. In this study, we evaluated lung damage over time by three types of ZnO NPs (L-serine, citrate, and pristine) following the ...
Ayoung Jung +6 more
doaj +1 more source
BMJ Open, 2022 Objectives To determine whether spontaneous reporting rates of myocarditis and pericarditis differed in immunocompromised patients compared with the whole population overall, and in terms of demographics, vaccine dose and time-to-onset.Design Systematic ...
Saad Shakir +2 more
doaj +1 more source
Journal of Cheminformatics, 2023 Proteochemometric (PCM) modelling is a powerful computational drug discovery tool used in bioactivity prediction of potential drug candidates relying on both chemical and protein information.
Marina Gorostiola González +7 more
doaj +1 more source
BMJ Open, 2022 Objectives To combine spontaneously reported data from multiple countries to estimate reporting rate, and better understand risk factors for myocarditis and pericarditis following COVID-19 messenger RNA (mRNA) vaccines.Design Systematic review of ...
Saad Shakir +2 more
doaj +1 more source