Results 21 to 30 of about 874,537 (314)

Expression of Concern to: Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatoxicity

Molecular Medicine, 2020
The Editors-in-Chief would like to alert readers that this article [1] is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the University of Liverpool with respect to the quantitative mass ...
Daniel James Antoine, Dominic P. Williams, Anja Kipar, Hugh Laverty, B. Kevin Park   +4 more
doaj   +1 more source

Drug Safety - Case Reports [PDF]

Drug Safety - Case Reports, 2014
Literature reports of suspected adverse drug reactions (ADRs) associated with medicinal products for human use are not just an integral part of signal detection activities, but are also an important source of information for professionals involved in patient management.
Joshi, Nitin, McMillan, Steve
openaire   +2 more sources

DrugEx v3: scaffold-constrained drug design with graph transformer-based reinforcement learning

Journal of Cheminformatics, 2023
Rational drug design often starts from specific scaffolds to which side chains/substituents are added or modified due to the large drug-like chemical space available to search for novel drug-like molecules.
Xuhan Liu, Kai Ye, Herman W. T. van Vlijmen, Adriaan P. IJzerman, Gerard J. P. van Westen   +4 more
doaj   +1 more source

Determination of Anthelmintic and Antiprotozoal Drug Residues in Fish Using Liquid Chromatography-Tandem Mass Spectrometry

Molecules, 2021
The objective of this study is to develop a comprehensive and simple method for the simultaneous determination of anthelmintic and antiprotozoal drug residues in fish. For sample preparation, we used the “quick, easy, cheap, effective, rugged, and safe” (
Eunjung Kim, Sihyun Park, Hyunjin Park, Jangduck Choi, Hae Jung Yoon, Jeong-Han Kim   +5 more
doaj   +1 more source

An exploration strategy improves the diversity of de novo ligands using deep reinforcement learning: a case for the adenosine A2A receptor

Journal of Cheminformatics, 2019
Over the last 5 years deep learning has progressed tremendously in both image recognition and natural language processing. Now it is increasingly applied to other data rich fields. In drug discovery, recurrent neural networks (RNNs) have been shown to be
Xuhan Liu, Kai Ye, Herman W. T. van Vlijmen, Adriaan P. IJzerman, Gerard J. P. van Westen   +4 more
doaj   +1 more source

Rewarding and Reinforcing Effects of 25H-NBOMe in Rodents

Brain Sciences, 2022
The drug 25H-NBOMe is a new psychoactive substance (NPS). The use of these substances is likely to pose a threat to public health because they elicit effects similar to those of known psychoactive substances with similar chemical structures.
Cheolmin Jo, Hyejin Joo, Dong-Hyun Youn, Jin Mook Kim, Young-Ki Hong, Na Young Lim, Kwan Soo Kim, Su-Jeong Park, Sun Ok Choi   +8 more
doaj   +1 more source

Papyrus: a large-scale curated dataset aimed at bioactivity predictions

Journal of Cheminformatics, 2023
With the ongoing rapid growth of publicly available ligand–protein bioactivity data, there is a trove of valuable data that can be used to train a plethora of machine-learning algorithms.
O. J. M. Béquignon, B. J. Bongers, W. Jespers, A. P. IJzerman, B. van der Water, G. J. P. van Westen   +5 more
doaj   +1 more source

Safety of antiobesity drugs [PDF]

Therapeutic Advances in Drug Safety, 2013
Obesity is a major health problem worldwide. Although diet and physical activity are crucial in the management of obesity, the long-term success rate is low. Therefore antiobesity drugs are of great interest, especially when lifestyle modification has failed.
Cheung, TT, SAMARANAYAKE, NR, Cheung, BMY   +2 more
openaire   +4 more sources

Monitoring of veterinary drug residues in livestock products with antimicrobial resistance

Applied Biological Chemistry
Antimicrobial resistance (AMR) in animal-derived products remains a global concern, while reports on veterinary drug (VD) residues in such products are relatively rare.
Dahae Park, Yu Ra Kim, Ji Young Kim, Jang-Duck Choi, Guiim Moon, Dong Woo Shin   +5 more
doaj   +1 more source

A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery

Scientific Reports, 2021
Members of the solute carrier (SLC) transporter protein family are increasingly recognized as therapeutic drug targets. The majority of drug screening assays for SLCs are based on the uptake of radiolabeled or fluorescent substrates.
Hubert J. Sijben, Julie J. E. van den Berg, Jeremy D. Broekhuis, Adriaan P. IJzerman, Laura H. Heitman   +4 more
doaj   +1 more source