Results 1 to 10 of about 835,419 (313)

Inner Ear Organoids: A Hydrogel-Based Platform for Drug Screening and Deafness Modeling. [PDF]

Neurosci Bull
Cao Y, Liu X, Chai R, He Z.
europepmc   +3 more sources

Structural Basis of VSIG3: The Ligand for VISTA

Frontiers in Immunology, 2021
B7 family members and their receptors play key roles in regulating T cell responses, and constitute very attractive targets for developing immunotherapeutic drugs.
Xiaoxue Xie, Caiping Chen, Wenting Chen, Jingwei Jiang, Lanlan Wang, Tingting Li, Hongbin Sun, Jun Liu   +7 more
doaj   +1 more source

Identification of active small-molecule modulators targeting the novel immune checkpoint VISTA

BMC Immunology, 2021
Background Cancer immunotherapy has gained increasing popularity as a novel approach to treat cancer. A member of the B7 family, V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a novel immune checkpoint that regulates a broad spectrum ...
Ting-ting Li, Jing-wei Jiang, Chen-xin Qie, Chun-xiao Xuan, Xin-lei Hu, Wan-mei Liu, Wen-ting Chen, Jun Liu   +7 more
doaj   +1 more source

Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models

Cell Death Discovery, 2023
Palmitoylation of proteins plays important roles in various physiological processes, such as cell proliferation, inflammation, cell differentiation etc. However, inhibition of protein palmitoylation has led to few new drugs to date.
Yumeng Wang, Shujie Zhang, Huiqin He, Hongyi Luo, Yannan Xia, Yuanyuan Jiang, Jingwei Jiang, Li Sun   +7 more
doaj   +1 more source

Rhamnan sulphate from green algae Monostroma nitidum improves constipation with gut microbiome alteration in double-blind placebo-controlled trial

Scientific Reports, 2021
Rhamnan sulphate (RS), a sulphated polysaccharide from Monostroma nitidum, possesses several biological properties that help in treating diseases such as viral infection, thrombosis, and obesity.
Yasuhito Shimada, Masahiro Terasawa, Fumiyoshi Okazaki, Hiroko Nakayama, Liqing Zang, Kaoru Nishiura, Koichi Matsuda, Norihiro Nishimura   +7 more
doaj   +1 more source

The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke

Journal of Neuroinflammation, 2020
Background Spontaneous functional recovery occurs during the acute phase after stroke onset, but this intrinsic recovery remains limited. Therefore, exploring the mechanism underlying spontaneous recovery and identifying potential strategies to promote ...
Hao Sun, Xinran He, Xia Tao, Tingting Hou, Mingming Chen, Meijun He, Hong Liao   +6 more
doaj   +1 more source

Exploring Quercetin Anti-Osteoporosis Pharmacological Mechanisms with In Silico and In Vivo Models

Life, 2022
Since osteoporosis critically influences the lives of patients with a high incidence, effective therapeutic treatments are important. Quercetin has been well recognized as a bone-sparing agent and thus the underlying mechanisms warrant further ...
Ying Hu, Wei Yuan, Na Cai, Kun Jia, Yunlong Meng, Fei Wang, Yurui Ge, Huiqiang Lu   +7 more
doaj   +1 more source

TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Transforming growth factor‐β‐activated kinase 1 (TAK1) plays a key role in regulating fibroblast and myoblast proliferation and differentiation. However, the TAK1 changes associated with Duchenne muscular dystrophy (DMD) are poorly understood,
Dengqiu Xu, Sijia Li, Lu Wang, Jingwei Jiang, Lei Zhao, Xiaofei Huang, Zeren Sun, Chunjie Li, Lixin Sun, Xihua Li, Zhenzhou Jiang, Luyong Zhang   +11 more
doaj   +1 more source

The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

Journal of Neuroinflammation, 2018
Background Alzheimer’s disease is characterized by progressive accumulation of β-amyloid (Aβ)-containing amyloid plaques, and microglia play a critical role in internalization and degradation of Aβ. Our previous research confirmed that Nogo-66 binding to
Yinquan Fang, Jianing Wang, Lemeng Yao, Chenhui Li, Jing Wang, Yuan Liu, Xia Tao, Hao Sun, Hong Liao   +8 more
doaj   +1 more source

A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1

Journal of Cachexia, Sarcopenia and Muscle, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by the loss of dystrophin, which results in inflammation, fibrosis, and the inhibition of myoblast differentiation in skeletal muscle.
Dengqiu Xu, Lei Zhao, Jingwei Jiang, Sijia Li, Zeren Sun, Xiaofei Huang, Chunjie Li, Tao Wang, Lixin Sun, Xihua Li, Zhenzhou Jiang, Luyong Zhang   +11 more
doaj   +1 more source