Results 1 to 10 of about 120,380 (317)

Synthesis and Discovery of Ligustrazine–Heterocycle Derivatives as Antitumor Agents

Frontiers in Chemistry, 2022
Ligustrazine (TMP) is a natural pyrazine alkaloid extracted from the roots of Ligusticum Chuanxiong Hort, which has the potential as an antitumor agent.
Shitang Ma, Shitang Ma, Shitang Ma, Ning Zhang, Jiafu Hou, Shijuan Liu, Jiawen Wang, Baowei Lu, Fucheng Zhu, Peipei Wei, Ge Hong, Tianjun Liu   +11 more
doaj   +2 more sources

Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism

BMC Cancer, 2020
Background Despite an improvement of prognosis in breast and colon cancer, the outcome of the metastatic disease is still severe. Microevolution of cancer cells often leads to drug resistance and tumor-recurrence.
Jérôme Ruhnau, Jonas Parczyk, Kerstin Danker, Britta Eickholt, Andreas Klein   +4 more
doaj   +3 more sources

Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening

Frontiers in Physiology, 2017
Introduction: Cell-based assays using three-dimensional (3D) cell cultures may reflect the antitumor activity of compounds more accurately, since these models reproduce the tumor microenvironment better.Methods: Here, we report a comparative analysis of ...
Robson L. F. Amaral, Mariza Miranda, Priscyla D. Marcato, Kamilla Swiech   +3 more
doaj   +2 more sources

Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells

BMC Complementary Medicine and Therapies, 2021
Background Lung cancer is one of the leading causes of death worldwide due to its strong proliferative and metastatic capabilities. The suppression of these aggressive behaviors is of interest in anticancer drug research and discovery.
Hien Minh Nguyen, Hoai Thi Nguyen, Suthasinee Seephan, Hang Bich Do, Huy Truong Nguyen, Duc Viet Ho, Varisa Pongrakhananon   +6 more
doaj   +2 more sources

Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine

Cell Death and Disease, 2023
Pancreatic cancer is a highly aggressive cancer, and is primarily treated with gemcitabine, with increasing resistance. SIRT6 as a member of sirtuin family plays important roles in lifespan and diverse diseases, such as cancer, diabetes, inflammation and
Nannan Song, Xian Guan, Siqi Zhang, Yanqing Wang, Xuekai Wang, Zhongxia Lu, Daochen Chong, Jennifer Yiyang Wang, Rilei Yu, Wengong Yu, Tao Jiang, Yuchao Gu   +11 more
doaj   +2 more sources

The identification of potent dual-target monopolar spindle 1 (MPS1) and histone deacetylase 8 (HDAC8) inhibitors through pharmacophore modeling, molecular docking, molecular dynamics simulations, and biological evaluation [PDF]

Frontiers in Pharmacology
BackgroundOverexpression of monopolar spindle 1 (MPS1) and histone deacetylase 8 (HDAC8) is associated with the proliferation of liver cancer cells, so simultaneous inhibition of both MPS1 and HDAC8 could offer a promising therapeutic approach for the ...
Huilian Hua, Lixia Guan, Bo Pan, Junyi Gao, Yifei Geng, Miao-Miao Niu, Zhiqin Li, Jindong Li   +7 more
doaj   +2 more sources

Targeting of focal adhesion kinase enhances the immunogenic cell death of PEGylated liposome doxorubicin to optimize therapeutic responses of immune checkpoint blockade

Journal of Experimental & Clinical Cancer Research
Backgrounds Immune checkpoint blockade (ICB) is widely considered to exert long-term treatment benefits by activating antitumor immunity. However, many cancer patients show poor clinical responses to ICB due in part to the lack of an immunogenic niche ...
Baoyuan Zhang, Ning Li, Jiaming Gao, Yuxi Zhao, Jun Jiang, Shuang Xie, Cuiping Zhang, Qingyu Zhang, Leo Liu, Zaiqi Wang, Dongmei Ji, Lingying Wu, Ruibao Ren   +12 more
doaj   +2 more sources

Repurposing the Antibacterial Activity of the Drug Teniposide Against Gram-Positive Bacteria

Cellular Microbiology
Drug repurposing is sparking considerable interest due to reduced costs and development times. The current study details the screening of teniposide, an antitumor drug, for its antibacterial activity against both Gram-positive and Gram-negative strains ...
Federica Dell’Annunziata, Veronica Folliero, Roberta Della Marca, Francesca Palma, Giuseppina Sanna, Anna De Filippis, Pasquale Pagliano, Aldo Manzin, Gianluigi Franci, Massimiliano Galdiero   +9 more
doaj   +2 more sources

Ivosidenib enhances cisplatin sensitivity in ovarian cancer by reducing cancer cell stemness. [PDF]

Cancer Drug Resist
Aim: Cancer stem cells (CSCs) are pivotal in mediating platinum resistance in ovarian cancer. This study aimed to screen compounds sensitizing CSCs to cisplatin by using a small molecule inhibitor library.
Chen M, Huang L, Zhao S, Zhu M, Sun S, Li W, Cai J, Peng M, Wen Y, Wang Z.   +9 more
europepmc   +2 more sources

Identification of Novel HPK1 Hit Inhibitors: From In Silico Design to In Vitro Validation. [PDF]

Int J Mol Sci
Hematopoietic progenitor kinase 1 (HPK1), a negative regulator of T-cells, B-cells, and dendritic cells, has gained attention in antitumor immunotherapy research over the past decade.
Isawi IH, Obeidat RM, Alnabulsi S, Al Zoubi R.   +3 more
europepmc   +2 more sources