Results 1 to 10 of about 14,958 (94)

Stability of furosemide and torasemide in parenteral nutrition admixture [PDF]

open access: yesActa Poloniae Pharmaceutica, 2023
Furosemide and torasemide (loop diuretics) are used to treat hypertension or pulmonary edema. They are often administered in the parenteral route. In critically ill patients, there is a problem of a limited number of venous accesses, which complicates ...
Szymon Tomczak   +2 more
doaj   +1 more source

Stability Tests and Analytical Methods of Tacrolimus: A Review [PDF]

open access: yesImmunoAnalysis, 2022
Tacrolimus is an immunosuppressive drug widely used in organ or tissue transplantation. Furthermore, its anti-inflammatory effects are employed in treatments for psoriasis, uveitis, and vernal keratoconjunctivitis.
Sara Sajjadi   +2 more
doaj   +1 more source

Interaction of letrozole and its degradation products with aromatase: chemometric assessment of kinetics and structure-based binding validation

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2022
Letrozole is one of the most prescribed drugs for the treatment of breast cancer in post-menopausal women, and it is endowed with selective peripheral aromatase inhibitory activity.
Michele De Luca   +6 more
doaj   +1 more source

Exploring Enzymatic Hydrolysis of Urine Samples for Investigation of Drugs Associated with Drug-Facilitated Sexual Assault

open access: yesPharmaceuticals, 2023
Analyzing urine is common in drug-facilitated sexual assault cases if the analysis of blood is not optimal. The efficient enzymatic pretreatment of urine is important for cleaving glucuronides and improving the detection of the parent drug.
Kathrine Skov   +4 more
doaj   +1 more source

Influence of manufacturing procedure on stability of Unguentum contra perniones preparations [PDF]

open access: yesVojnosanitetski Pregled, 2005
Background. Application of various technological procedures for the manufacture of officinal preparation ointment against chilblains (Unguentum contra perniones) produce essential variations in the quality and stability of the final product. Changing the
Bošković Mirjana   +1 more
doaj   +1 more source

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

open access: yeseLife, 2021
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage ...
Xiangrong Chen   +13 more
doaj   +1 more source

Cistracurium Besylate 10 mg/mL Solution Compounded in a Hospital Pharmacy to Prevent Drug Shortages: A Stability Study Involving Four Degradation Products

open access: yesPharmaceutics, 2023
Background: Stability study of a 10 mg/mL injectable cisatracurium solution stored refrigerated in amber glass ampoules for 18 months (M18). Methods: 4000 ampoules were aseptically compounded using European Pharmacopoeia (EP)-grade cisatracurium besylate,
Marine Roche   +7 more
doaj   +1 more source

Challenges of Dissolution Methods Development for Soft Gelatin Capsules

open access: yesPharmaceutics, 2021
Recently, the development of soft gelatin capsules (SGCs) dosage forms has attracted a great deal of interest in the oral delivery of poorly water-soluble drugs.
Festo Damian   +4 more
doaj   +1 more source

Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions

open access: yesMolecules, 2021
The evolution of different antimicrobial drugs in terrestrial, microgravity and hypergravity conditions is presented within this review, in connection with their implementation during human space exploration.
Ágota Simon   +3 more
doaj   +1 more source

Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease

open access: yesPharmaceutics, 2022
Janus kinase (JAK) inhibitors, such as tofacitinib (Xeljanz) and filgotinib (Jyseleca), have been approved for treatment of ulcerative colitis with several other JAK inhibitors in late-stage clinical trials for inflammatory bowel disease (IBD).
Vipul Yadav   +16 more
doaj   +1 more source

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