Drug Stability: ICH versus Accelerated Predictive Stability Studies [PDF]
Pharmaceutics, 2022 The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), along with the World Health Organization (WHO), has provided a set of guidelines (ICH Q1A-E, Q3A-B, Q5C, Q6A-B) intended to unify the standards
Olga González-González +6 more
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Cyclodextrins and Their Derivatives as Drug Stability Modifiers. [PDF]
Pharmaceuticals (Basel), 2023 Cyclodextrins (CDs) are cyclic oligosaccharides that contain a relatively hydrophobic central cavity and a hydrophilic outer surface. They are widely used to form non-covalent inclusion complexes with many substances.
Aiassa V, Garnero C, Zoppi A, Longhi MR.
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Glycopeptide antibiotic drug stability in aqueous solution. [PDF]
AAPS Open, 2022 Glycopeptide antimicrobials are a class of naturally occurring or semi-synthetic glycosylated products that have shown antibacterial activity against gram-positive organisms by inhibiting cell-wall synthesis.
Jakaria SM, Budil DE, Murtagh J.
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Solid-in-Oil-in-Water Emulsion: An Innovative Paradigm to Improve Drug Stability and Biological Activity. [PDF]
AAPS PharmSciTech, 2021 An emulsion is a biphasic dosage form comprising of dispersed phase containing droplets that are uniformly distributed into a surrounding liquid which forms the continuous phase.
Sawant A, Kamath S, Kg H, Kulyadi GP.
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Cistracurium Besylate 10 mg/mL Solution Compounded in a Hospital Pharmacy to Prevent Drug Shortages: A Stability Study Involving Four Degradation Products [PDF]
Pharmaceutics, 2023 Background: Stability study of a 10 mg/mL injectable cisatracurium solution stored refrigerated in amber glass ampoules for 18 months (M18). Methods: 4000 ampoules were aseptically compounded using European Pharmacopoeia (EP)-grade cisatracurium besylate,
Marine Roche +7 more
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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders: drug stability, targeting efficiency, and safety. [PDF]
Neural Regen ResVarious nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely studied. However, their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic strategies.
Zhang M +6 more
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Reverse Transcriptase Inhibitors Nanosystems Designed for Drug Stability and Controlled Delivery. [PDF]
Pharmaceutics, 2019 An in-depth analysis of nanotechnology applications for the improvement of solubility, distribution, bioavailability and stability of reverse transcriptase inhibitors is reported.
Grande F +7 more
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Drug stability analysis by Raman spectroscopy. [PDF]
Pharmaceutics, 2014 Pharmaceutical drugs are available to astronauts to help them overcome the deleterious effects of weightlessness, sickness and injuries. Unfortunately, recent studies have shown that some of the drugs currently used may degrade more rapidly in space ...
Shende C +3 more
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Biopolymeric Nanogel as a Drug Delivery System for Doxorubicin—Improved Drug Stability and Enhanced Antineoplastic Activity in Skin Cancer Cells [PDF]
PharmaceuticalsIn this study, doxorubicin was loaded in a chitosan–albumin nanogel with the aim of improving its stability and exploring the potential of the system in the treatment of skin cancer. Infrared spectroscopy and X-ray diffraction confirmed the encapsulation
Lyubomira Radeva +6 more
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A Robust Liquid Chromatographic Method for Confirmation of Drug Stability of Azithromycin in Bulk Samples, Tablets and Suspensions [PDF]
Pharmaceutics, 2017 A simple, isocratic and robust RP-HPLC method for the analysis of azithromycin was developed, validated and applied for the analysis of bulk samples, tablets and suspensions.
Alex O. Okaru +4 more
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