Results 1 to 10 of about 1,309,705 (358)

Drug Stability Analysis by Raman Spectroscopy [PDF]

open access: yesPharmaceutics, 2014
Pharmaceutical drugs are available to astronauts to help them overcome the deleterious effects of weightlessness, sickness and injuries. Unfortunately, recent studies have shown that some of the drugs currently used may degrade more rapidly in space ...
Chetan Shende   +3 more
doaj   +5 more sources

Cyclodextrins and Their Derivatives as Drug Stability Modifiers [PDF]

open access: yesPharmaceuticals, 2023
Cyclodextrins (CDs) are cyclic oligosaccharides that contain a relatively hydrophobic central cavity and a hydrophilic outer surface. They are widely used to form non-covalent inclusion complexes with many substances. Although such inclusion complexes typically exhibit higher aqueous solubility and chemical stability than pure drugs, it has been shown ...
Virginia Aiassa   +3 more
openaire   +5 more sources

Drug Stability: ICH versus Accelerated Predictive Stability Studies [PDF]

open access: yesPharmaceutics, 2022
The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), along with the World Health Organization (WHO), has provided a set of guidelines (ICH Q1A-E, Q3A-B, Q5C, Q6A-B) intended to unify the standards
Olga González-González   +6 more
doaj   +2 more sources

A Robust Liquid Chromatographic Method for Confirmation of Drug Stability of Azithromycin in Bulk Samples, Tablets and Suspensions [PDF]

open access: yesPharmaceutics, 2017
A simple, isocratic and robust RP-HPLC method for the analysis of azithromycin was developed, validated and applied for the analysis of bulk samples, tablets and suspensions.
Alex O. Okaru   +4 more
doaj   +2 more sources

Biopolymeric Nanogel as a Drug Delivery System for Doxorubicin—Improved Drug Stability and Enhanced Antineoplastic Activity in Skin Cancer Cells [PDF]

open access: yesPharmaceuticals
In this study, doxorubicin was loaded in a chitosan–albumin nanogel with the aim of improving its stability and exploring the potential of the system in the treatment of skin cancer. Infrared spectroscopy and X-ray diffraction confirmed the encapsulation
Lyubomira Radeva   +6 more
doaj   +2 more sources

Stability of antimycobacterial drugs in susceptibility testing [PDF]

open access: greenAntimicrobial Agents and Chemotherapy, 1992
Aqueous solutions of 0.02% isoniazid, 0.2% streptomycin, 0.2% para-aminosalicylate, and 0.5% ethambutol and ethylene glycol solutions of 0.5% ethionamide stored at 3 to 7 degrees C remained stable for 1 year, as did aqueous solutions of 0.05% ethionamide hydrochloride, 0.05% kanamycin, 0.05% viomycin, and 0.1% capreomycin stored at -20 degrees C.
M E Griffith, Howard L. Bodily
openalex   +5 more sources

Predicting drug response of tumors from integrated genomic profiles by deep neural networks [PDF]

open access: yesarXiv, 2018
The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insights into the oncogenic features modulating drug response. A recent screening of ~1,000 cancer cell lines to a collection of anti-cancer drugs illuminated the link between genotypes and vulnerability.
Chen, Hung-I Harry   +7 more
arxiv   +3 more sources

Molecular Dynamics Studies on HIV-1 Protease: Drug Resistance and Folding Pathways [PDF]

open access: yesarXiv, 2001
Drug resistance to HIV-1 Protease involves accumulation of multiple mutations in the protein. Here we investigate the role of these mutations by using molecular dynamics simulations which exploit the influence of the native-state topology in the folding process.
Carloni, Paolo   +3 more
arxiv   +5 more sources

Compressed Oxygen in Drug Stability Experiments

open access: bronzeChemical and Pharmaceutical Bulletin, 2007
A drug stability experiment accelerated by compressed oxygen was established. The stability of 10% ascorbic acid solution as a model was studied and the kinetic parameters were obtained with the newly established experimental method. Because ascorbic acid degrades under both anaerobic and aerobic conditions, the total rate constant k(total) can be ...
Yan Shi   +6 more
openalex   +5 more sources

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