Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota
Pharmaceutics, 2021 Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher.
Laura E. McCoubrey +5 more
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Crystals, 2023 Pyrazinamide may exist in at least four known polymorphic forms, which were obtained experimentally. One of these polymorphs, (α), shows outstanding mechanical properties, demonstrating a significant anisotropic plasticity in a three-point bending test ...
Aleksandr S. Dubok, Denis A. Rychkov
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Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization [PDF]
, 2017 En route towards improved delivery systems for targeted chemotherapy, we propose a straightforward approach for the hydrophobic modification of the acrylamide N-(2-Hydroxyethyl) acrylamide (HEAm).
De Geest, Bruno +8 more
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Compressed Oxygen in Drug Stability Experiments
Chemical and Pharmaceutical Bulletin, 2007 A drug stability experiment accelerated by compressed oxygen was established. The stability of 10% ascorbic acid solution as a model was studied and the kinetic parameters were obtained with the newly established experimental method. Because ascorbic acid degrades under both anaerobic and aerobic conditions, the total rate constant k(total) can be ...
Yan Shi +6 more
openalex +5 more sources
In vitro and in vivo screening for novel essential cell-envelope proteins in Pseudomonas aeruginosa [PDF]
, 2015 The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required.
Bragonzi, Alessandra +5 more
core +1 more source
Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability [PDF]
Pharmaceutics, 2018 Many approaches have been developed over time to counter the bioavailability limitations of poorly soluble drugs. With advances in nanotechnology in recent decades, science and industry have been approaching this issue through the formulation of drugs as nanocrystals, which consist of pure drugs and a minimum of surface active agents required for ...
Maria Rosa Gigliobianco +3 more
openaire +7 more sources
Hydrogen-bonded multilayer thin films and capsules based on poly(2-n-propyl-2-oxazoline) and tannic acid : investigation on intermolecular forces, stability, and permeability [PDF]
, 2019 In recent years, hydrogen-bonded multilayer thin films and capsules based on neutral and nontoxic building blocks have been receiving interest for the design of stimuli-responsive drug delivery systems and for the preparation of thin-film coatings ...
Hoogenboom, Richard +5 more
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Stability of peptide drugs in the colon
European Journal of Pharmaceutical Sciences, 2015 This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser(4)]-gonadorelin, deslorelin, and goserelin) in a model of the large intestine using mixed ...
Abdul Basit +4 more
openaire +3 more sources
EVALUATION OF THE STABILITY OF VIGABATRIN IN HOSPITALAR EXTEMPORANEOUS FORMULATIONS
Drug Analytical Research, 2019 The aim of this study was to analyze the chemical stability of the anticonvulsant vigabatrin extemporaneous formulation from tablets in storage conditions of different temperatures and types of packaging used.
Marcio Vinicius Ayres +4 more
doaj +1 more source
Adaptive HIV-1 evolutionary trajectories are constrained by protein stability [PDF]
, 2017 Despite the use of combination antiretroviral drugs for the treatment of HIV-1 infection, the emergence of drug resistance remains a problem. Resistance may be conferred either by a single mutation or a concerted set of mutations.
Kandathil, Shaun M. +3 more
core +1 more source