Results 41 to 50 of about 3,780,548 (370)

Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundThalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which is known to influence ...
Hyung Gon Lee, Woong Mo Kim, Myung Ha Yoon, A Reum Park, Jeong-Il Choi   +4 more
doaj   +1 more source

Metformin synergistically increases the anticancer effects of lapatinib through induction of apoptosis and modulation of Akt/AMPK pathway in SK-BR3 breast cancer cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Combination chemotherapy is a beneficial intervention for breast cancer, versus single therapy. We investigated the effect of Metformin (Met) on Lapatinib (Lap)-induced apoptosis in SK-BR3 cells.
Davood Neamati, Azam Khedri, Mohammad Aberomand, Ali-Asghar Hemati, Maryam Mohammadzadeh, Kourosh Akbari Baghbani, Ghorban Mohammadzadeh   +6 more
doaj   +1 more source

Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method

Journal of Venomous Animals and Toxins including Tropical Diseases, 2008
Propolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South
R. P. Mantovani, V. L. M. Rall, J. E. N. Batalha, A. A. H. Fernandes, A. Fernandes Junior   +4 more
doaj   +1 more source

Fundamental Concepts in the Assessment of Interaction of Biological Response Modifiers with other Agents

Canadian Journal of Infectious Diseases, 1992
The universal response surface approach (URSA) was developed to assess the nature and intensity of drug interactions, ie, synergism. antagonism and additivity.
William R Greco, Wlodzimierz E Dembinski
doaj   +1 more source

In vitro screening of known drugs identified by scaffold hopping techniques shows promising leishmanicidal activity for suramin and netilmicin

BMC Research Notes, 2018
Objective The rapid emergence of drug resistant Leishmanial strains makes it imperative to continue the development of cheap and effective drugs against the parasite.
Supriya Khanra, Y. Pavan Kumar, Jyotirmayee Dash, Rahul Banerjee   +3 more
doaj   +1 more source

Hemodynamic Effects of Co-administration of Midazolam during Anesthesia Induction with Propofol and Remifentanil in Hypertensive Patients [PDF]

Kosin Medical Journal, 2017
Objectives Propofol, midazolam and remifentanil are commonly used for clinical anesthesia. We compared the effects of midazolam-propofol-remifentanil and propofol-remifentanil on hemodynamic responses during anesthesia induction in hypertensive patients.
Ju Deok Kim, Joo Won Kim, His Chiang Kung, Jun Hong Kang, Hye Young Shin, Doo Sik Kim, Sie Jeong Ryu, Kyung Han Kim   +7 more
doaj   +1 more source

Allosteric cross-talk in chromatin can mediate drug-drug synergy

Nature Communications, 2017
Allostery and drug-drug synergism can yield potential novel therapies with existing molecules. Here, the authors provide evidence that two unrelated drugs have increased cytotoxicity in cancer cells, which coincides with increased formation of chromatin ...
Zenita Adhireksan, Giulia Palermo, Tina Riedel, Zhujun Ma, Reyhan Muhammad, Ursula Rothlisberger, Paul J. Dyson, Curt A. Davey   +7 more
doaj   +1 more source

Supramolecular assemblies of rifampicin and cationic bilayers: preparation, characterization and micobactericidal activity

BMC Biotechnology, 2011
Background Cationic bilayers based on the inexpensive synthetic lipid dioctadecyldimethylammonium bromide (DODAB) have been useful as carriers for drug delivery, immunoadjuvants for vaccines and active antimicrobial agents.
Mamizuka Elsa M, Barbassa Lilian, Carmona-Ribeiro Ana M   +2 more
doaj   +1 more source

Combined drug triads for synergic neuroprotection in retinal degeneration

Biomedicine & Pharmacotherapy, 2022
This review focuses on retina degeneration occurring during glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP), and on the potential therapeutic use of triads of repositioned medicines, addressed to distinct but complementary targets, to prevent, delay or stop retina cell death.
Maneu, Victoria, Lax, Pedro, De Diego, Antonio Miguel G., Cuenca, Nicolás, García, Antonio G.   +4 more
openaire   +3 more sources

Synergism in Antiplasmodial Activities of Artemether and Lumefantrine in Combination with Securidaca longipedunculata Fresen (Polygalaceae)

Plants, 2021
Malaria is the most lethal parasitic disease in the world. The frequent emergence of resistance by malaria parasites to any drug is the hallmark of sustained malaria burden.
Douglas O. Ochora, Esezah K. Kakudidi, Jane Namukobe, Perpetua Ipulet, Dancan M. Wakoli, Winnie Okore, Edwin W. Mwakio, Redempthah A. Yeda, Agnes C. Cheruiyot, Dennis W. Juma, Ben Andagalu, Amanda L. Roth, Bernhards R. Ogutu, Abiy Yenesew, Hoseah M. Akala   +14 more
doaj   +1 more source