Results 31 to 40 of about 1,512,902 (358)
A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]
, 2019 Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia +14 more
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Recent progress in mitochondria-targeted drug and drug-free agents for cancer therapy [PDF]
, 2019 The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions of the cell. Being a critical center of metabolic activities and involved in many diseases, mitochondria have been attracting attention as a potential target for
Jeena, M.T. +3 more
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Anticancer therapeutics: “Addictive” targets, multi-targeted drugs, new drug combinations
Drug Resistance Updates, 2005 The annual meeting of the American Association for Cancer Research (AACR) provided a panoramic view of new developments and trends in cancer research. In the area of new drug development, a recurrent theme was receptor tyrosine kinase (TK) inhibitors, with multi-targeted, small molecule inhibitors - highly potent against a family of receptors such as ...
Broxterman, H.J., Georgopapadakou, NH
openaire +3 more sources
Pharmaceutics, 2021 Pharmaceutical excipients (PEs) are substances included in drug formulations. Recent studies have revealed that some PEs can affect the activity of metabolic enzymes and drug transporters; however, the effects of PEs on CYP2C8 and its interaction ...
Chengming Wen +5 more
doaj +1 more source
Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment [PDF]
, 2014 The rapidly increasing interest in the synthesis of antibody–drug conjugates as powerful targeted anticancer agents demonstrates the growing appreciation of the power of antibodies and antibody fragments as highly selective targeting moieties.
Boyle, Ross W. +6 more
core +1 more source
Acta Pharmaceutica Sinica B, 2020 Accurate tumor targeting, deep penetration and superb retention are still the main pursuit of developing excellent nanomedicine. To achieve these requirements, a stepwise stimuli-responsive strategy was developed through co-administration tumor ...
Congcong Lin +8 more
doaj +1 more source
, 2015 Mass campaigns with antimalarial drugs are potentially a powerful tool for local elimination of malaria, yet current diagnostic technologies are insufficiently sensitive to identify all individuals who harbor infections.
Bever, Caitlin A. +5 more
core +3 more sources
Evaluation of liposomes coated with a pH responsive polymer [PDF]
, 2010 Liposomes have been coated with the pH responsive polymer, Eudragit S100, and the formulation's potential for lower gastrointestinal (GI) targeting following oral administration assessed.
Barea, M.J. +3 more
core +1 more source
Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma
Acta Pharmaceutica Sinica B, 2019 Due to the critical correlation between inflammation and carcinogenesis, a therapeutic candidate with anti-inflammatory activity may find application in cancer therapy.
Xi Cao +7 more
doaj +1 more source
Highly pathogenic coronaviruses: thrusting vaccine development in the spotlight
Acta Pharmaceutica Sinica B, 2020 Coronaviruses (CoVs) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS).
Chunting He, Ming Qin, Xun Sun
doaj +1 more source