Results 41 to 50 of about 2,667,430 (358)

Role of gemcitabine in the treatment of advanced and metastatic breast cancer [PDF]

, 2003
Gemcitabine is an antimetabolite drug with proven antitumor activity and tolerability in metastatic breast cancer. In a total of nine studies, gemcitabine monotherapy has reached response rates of up to 37% in the first-line setting, 26% in the second ...
Heinemann, Volker
core   +1 more source

Analysis of Combination Drug Therapy to Develop Regimens with Shortened Duration of Treatment for Tuberculosis

PLoS ONE, 2014
Rationale Tuberculosis remains a worldwide problem, particularly with the advent of multi-drug resistance. Shortening therapy duration for Mycobacterium tuberculosis is a major goal, requiring generation of optimal kill rate and resistance-suppression ...
G. Drusano, M. Neely, M. van Guilder, A. Schumitzky, David Brown, Steven Fikes, C. Peloquin, A. Louie   +7 more
semanticscholar   +1 more source

Arterial anatomy and arteriographic diagnosis of arteriogenic impotence [PDF]

, 1988
One hundred twenty-six bilateral selective arteriographic examinations of the iliopudendal vascular tree were performed after comprehensive multidisciplinary evaluation in patients with chronic erectile dysfunction.
Bähren, Wolfgang, Gall, Helmut, Scherb, Wolfgang, Stief, Christian Georg, Thon, Walter F.   +4 more
core   +1 more source

Tumor‐Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy

Advancement of science, 2019
The combination of chemotherapeutic drugs and reactive oxygen species (ROS) is a promising strategy to achieve improved anticancer effect. Herein, a nanomedicine (LaCIONPs) that can achieve tumor‐specific chemotherapeutic drug release and ROS generation ...
Sheng Wang, Zhantong Wang, Guocan Yu, Zijian Zhou, Orit Jacobson, Yijing Liu, Ying Ma, Fuwu Zhang, Zhi-Yi Chen, Xiaoyuan Chen   +9 more
semanticscholar   +1 more source

Giant cells lepromatous leprosy. Diffuse dermatitis with exuberant foreign body giant cells in treated lepromatous leprosy

Biomédica: revista del Instituto Nacional de Salud, 2019
Patients with lepromatous leprosy that have received treatment for many years usually get follow up biopsies for persistent skin lesions or positive bacilloscopy even if the values are lower than in the initial bacilloscopy.
Gerzaín Rodríguez, Viviana Arias
doaj   +1 more source

The relation between submaximal aerobic exercise improving vascular elasticity through loss of visceral fat and antihypertensive

Clinical and Experimental Hypertension, 2021
Purpose: We sought to observe the effect of submaximal aerobic exercise on abdominal obesity in hypertension patients and to clarify a correlation between blood pressure improvement and visceral fat, along with arterial elasticity. Materials and Methods:
Hong Fang, Chi Liu, Omer Cavdar
doaj   +1 more source

End-to-End $n$-ary Relation Extraction for Combination Drug Therapies [PDF]

arXiv, 2023
Combination drug therapies are treatment regimens that involve two or more drugs, administered more commonly for patients with cancer, HIV, malaria, or tuberculosis. Currently there are over 350K articles in PubMed that use the "combination drug therapy" MeSH heading with at least 10K articles published per year over the past two decades.
arxiv  

A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

eLife, 2019
Curative cancer therapies are uncommon and nearly always involve multi-drug combinations developed by experimentation in humans; unfortunately, the mechanistic basis for the success of such combinations has rarely been investigated in detail, obscuring ...
A. Palmer, Christopher Chidley, P. Sorger   +2 more
semanticscholar   +1 more source

Olmesartan-based monotherapy vs combination therapy in hypertension: A meta-analysis based on age and chronic kidney disease status. [PDF]

, 2017
Antihypertensive monotherapy is often insufficient to control blood pressure (BP). Several recent guidelines advocate for initial combination drug therapy in many patients. This meta-analysis of seven randomized, double-blind studies (N = 5888) evaluated
Bakris, George, Deedwania, Prakash, Reimitz, Paul-Egbert, Weber, Michael   +3 more
core   +1 more source

The effects of combination treatments on drug resistance in chronic myeloid leukaemia: an evaluation of the tyrosine kinase inhibitors axitinib and asciminib

BMC Cancer, 2020
Background Chronic myeloid leukaemia is in principle a treatable malignancy but drug resistance is lowering survival. Recent drug discoveries have opened up new options for drug combinations, which is a concept used in other areas for preventing drug ...
H. Jonathan G. Lindström, Ran Friedman
doaj   +1 more source