Results 31 to 40 of about 1,680,438 (318)

Drug therapy: Telaprevir [PDF]

Hepatology, 2011

Michael D, Leise, W Ray, Kim, Katherine M, Canterbury, John J, Poterucha   +3 more
openaire   +2 more sources

Prefusion-specific antibody-derived peptides trivalently presented on DNA-nanoscaffolds as an innovative strategy against RSV entry

Frontiers in Virology, 2022
Human respiratory syncytial virus (RSV) is the primary cause of acute lower respiratory tract infections in children and the elderly worldwide, for which neither a vaccine nor an effective therapy is approved.
Leila Issmail, Christin Möser, Christian Jäger, Basma Altattan, Daniel Ramsbeck, Martin Kleinschmidt, Mirko Buchholz, David Smith, David Smith, David Smith, Thomas Grunwald   +10 more
doaj   +1 more source

Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity

Human Genomics
Background Individual assessment of CYP enzyme activities can be challenging. Recently, the potato alkaloid solanidine was suggested as a biomarker for CYP2D6 activity.
Johanna I. Kiiski, Mikko Neuvonen, Mika Kurkela, Päivi Hirvensalo, Kreetta Hämäläinen, E. Katriina Tarkiainen, Johanna Sistonen, Mari Korhonen, Sofia Khan, Arto Orpana, Anne M. Filppula, Marko Lehtonen, Mikko Niemi   +12 more
doaj   +1 more source

Distinct types of VHHs in Alpaca

Frontiers in Immunology
IntroductionVHHs (VH of heavy-chain-only antibodies) represent a unique alternative to Q7 conventional antibodies because of their smaller size, comparable binding affinity and biophysical properties.
Xinhao Wang, Lu Zhang, Yao Zhang, Jiaguo Li, Wenfeng Xu, Weimin Zhu   +5 more
doaj   +1 more source

Green light exposure aggravates high-fat diet feeding-induced hepatic steatosis and pancreatic dysfunction in male mice

Ecotoxicology and Environmental Safety, 2021
The increased incidence of metabolic syndrome (MetS) has been demonstrated to be closely associated with external environments, such as unhealthy ambient light exposure.
Shiyao Zhang, Mengyi Xu, Ziyue Shen, Changrui Shang, Wenxiang Zhang, Siyu Chen, Chang Liu   +6 more
doaj   +1 more source

Association analysis between chronic obstructive pulmonary disease and polymorphisms in circadian genes [PDF]

PeerJ, 2020
Background Circadian genes have been suggested to play an important role in lung pathology. However, it remains unknown whether polymorphisms of these genes are associated with chronic obstructive pulmonary disease (COPD).
Guo Chen, Jingwei Zhang, Lijuan Zhang, Xuan Xiong, Dongke Yu, Yuan Zhang   +5 more
doaj   +2 more sources

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs

Stem Cell Research & Therapy, 2023
Background Transplantation of differentiated cells from human-induced pluripotent stem cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of malignant cell transformation is essential for ensuring the safety of such ...
Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Kiyohiro Hashimoto, Nozomu Sakai, Shinya Asano, Saori Watanabe-Matsumoto, Takeshi Watanabe, Bunnai Saito, Hirokazu Matsumoto, Hikaru Ueno, Ryo Ito, Taro Toyoda   +11 more
doaj   +1 more source

aFGF Targeted Mediated by Novel Nanoparticles-Microbubble Complex Combined With Ultrasound-Targeted Microbubble Destruction attenuates Doxorubicin-Induced Heart Failure via Anti-Apoptosis and Promoting Cardiac Angiogenesis

Frontiers in Pharmacology, 2021
The purpose of this study was to evaluate the protective effect of acidic fibroblast growth factor targeted mediated by novel nanoparticles–cationic lipid microbubbles complex (aFGF–NP + CPMBs) combined with ultrasound targeted microbubble destruction ...
Nan-Qian Zhou, Nan-Qian Zhou, Nan-Qian Zhou, Zhi-Xin Fang, Zhi-Xin Fang, Zhi-Xin Fang, Ning Huang, Ning Huang, Ning Huang, Yue Zuo, Yue Qiu, Yue Qiu, Yue Qiu, Li-Juan Guo, Ping Song, Ping Song, Ping Song, Jian Xu, Jian Xu, Jian Xu, Guang-rui Wan, Guang-rui Wan, Guang-rui Wan, Xin-Qiao Tian, Ya-ling Yin, Peng Li, Peng Li, Peng Li   +27 more
doaj   +1 more source