Results 101 to 110 of about 5,099,978 (377)
Microorganisms, 2023 Antibiotics have played a crucial role in the reduction in the incidence of TB globally as evidenced by the fact that before the mid-20th century, the mortality rate within five years of the onset of the disease was 50%.
Giuseppe Mancuso +4 more
doaj +1 more source
Tolerance to the Prophylactic Effects of Carbamazepine and Related Mood Stabilizers in the Treatment of Bipolar Disorders [PDF]
, 2011 Tolerance development after successful long-term treatment of bipolar disorder is under recognized, as are ways to prevent or show its occurrence or reverse it once it has occurred.
Bonduelle M. +9 more
core +2 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Cells, 2022 Mesenchymal stem cells (MSCs) or fibroblasts are one of the most abundant cell types in the tumor microenvironment (TME) exerting various anti- and pro-apoptotic effects during tumorigenesis, invasion, and drug treatment.
Flóra Vajda +9 more
doaj +1 more source
Improving the Performance of Bayesian Logistic Regression Model with Overdose Control in Oncology Dose-Finding Studies [PDF]
arXiv, 2021 An accurately identified maximum tolerated dose (MTD) serves as the cornerstone of successful subsequent phases in oncology drug development. Bayesian logistic regression model (BLRM) is a popular and versatile model-based dose-finding design.
arxiv
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Emerging Microbes and Infections, 2020 Bacterial persistence is one of the major causes of antibiotic treatment failure and the step stone for antibiotic resistance. However, the mechanism by which persisters arise has not been well understood.
Jin Zou +6 more
doaj +1 more source
Hyperbolic Molecular Representation Learning for Drug Repositioning [PDF]
arXiv, 2022 Learning accurate drug representations is essential for task such as computational drug repositioning. A drug hierarchy is a valuable source that encodes knowledge of relations among drugs in a tree-like structure where drugs that act on the same organs, treat the same disease, or bind to the same biological target are grouped together.
arxiv
Beyond Zero Tolerance: A Reality-Based Approach to Drug Education and School Discipline [PDF]
, 2013 Beyond Zero Tolerance is a comprehensive, cost-effective approach to secondary school drug education and school discipline that is all about helping teenagers by bolstering the student community and educational environment. This innovative model combines
Rodney Skager
core
Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence [PDF]
, 2010 Peer reviewedPublisher ...
Epp, Elias +10 more
core +3 more sources