Results 111 to 120 of about 4,947,330 (332)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Sensitivity and drug tolerance of antidrug antibody assays in relation to positive control characteristics.

Bioanalysis, 2018
AIM Detection and characterization of antidrug antibodies (ADA) play a key role in understanding the relation of ADA with safety and efficacy. Positive controls (PCs) are used to estimate the sensitivity and assay sensitivity in the presence of drug ...
D. Egging, Jos Verhagen, Karin de Laat-Arts, Benny de Wit, Tinie van Boekel, M. Buurman, Jochem Eigenhuijsen, Karin Lubbers-Geuijen, Roel Mulder   +8 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Pathology of drug hypersensitivity reactions and mechanisms of immune tolerance

, 2022
Paul Thomson, Sean Hammond, Dean J. Naisbitt   +2 more
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

The Dosing Strategy to Improve Adherence to Roflumilast in Treatment for Chronic Obstructive Lung Disease: A Systemic Review and Meta-Analysis

International Journal of COPD
Jonghoo Lee,1,* Jae-Uk Song2,* 1Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea; 2Division of Pulmonary and Critical Care Medicine, Department of Internal ...
Lee J, Song JU
doaj  

House of cellulose – a new hideout for drug tolerant Mycobacterium tuberculosis

Microbial Cell, 2016
Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB). The treatment of TB requires administration of multiple drugs for long durations because of the unusual drug tolerance of Mtb. The phenotypic drug tolerance of genetically drug-susceptible Mtb in
Ashwani Kumar
doaj   +1 more source

STUDY OF TOLERANCE OF THE DRUG BASED ON QUARTZETIN BY BLOOD INDICATORS IN CLINICALLY HEALTHY DOGS

, 2021
N. Lisova, M. I. Zhyla, A. Rozumnyuk, N. Shkodyak, O. Pyatnychko, O. Sobodoch   +5 more
openalex   +2 more sources

Wnt/β-catenin inhibition disrupts drug-tolerance in isogenic carboplatin-resistant models of Triple-Negative Breast Cancer [PDF]

, 2021
Willy Antoni Abreu de Oliveira, Stijn Moens, Youssef El Laithy, Bernard K. van der Veer, Paraskevi Athanasouli, Emanuela Elsa Cortesi, Maria Francesca Baietti, Kian Peng Koh, Juan‐José Ventura, Frédéric Amant, Daniela Annibali, Frederic Lluı́s   +11 more
openalex   +1 more source

Distinct histone modifications denote early stress-induced drug tolerance in cancer

OncoTarget, 2017
Besides somatic mutations or drug efflux, epigenetic reprogramming can lead to acquired drug resistance. We recently have identified early stress-induced multi-drug tolerant cancer cells termed induced drug-tolerant cells (IDTCs).
A. Emran, D. Marzese, D. Menon, M. Stark, J. Torrano, H. Hammerlindl, Gao Zhang, Patricia Brafford, M. Salomon, N. Nelson, S. Hammerlindl, D. Gupta, G. Mills, Yiling Lu, R. Sturm, K. Flaherty, D. Hoon, B. Gabrielli, M. Herlyn, H. Schaider   +19 more
semanticscholar   +1 more source