Results 51 to 60 of about 5,099,978 (377)

The Tricalbin-Family Endoplasmic Reticulum-Plasma Membrane Tethering Proteins Attenuate ROS-Involved Caspofungin Sensitivity in Candida albicans

Microbiology Spectrum, 2022
The endoplasmic reticulum-plasma membrane (ER-PM) contacts are one kind of important membrane contact structures in eukaryotic cells, which mediate material and message exchange between the ER and the PM.
Li Yang, Hangqi Zhu, Mingchun Li, Qilin Yu   +3 more
doaj   +1 more source

Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance [PDF]

, 2013
Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson, Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of ...
Atkinson, Nigel S., Ghezzi, Alfredo, Krishnan, Harish R., Lew, Linda, Ong, Darryl S., Prado III, Francisco J.   +5 more
core   +3 more sources

Induction of Aspergillus fumigatus zinc cluster transcription factor OdrA/Mdu2 provides combined cellular responses for oxidative stress protection and multiple antifungal drug resistance

mBio, 2023
Zinc cluster transcription factors (Zcfs) encoding zcf genes are exclusive for fungi and required for multiple cellular processes including metabolism and development.
Christoph Sasse, Emmanouil Bastakis, Fruzsina Bakti, Annalena M. Höfer, Isabella Zangl, Christoph Schüller, Anna M. Köhler, Jennifer Gerke, Sven Krappmann, Florian Finkernagel, Rebekka Harting, Joseph Strauss, Kai Heimel, Gerhard H. Braus   +13 more
doaj   +1 more source

Hsp21potentiates antifungal drug tolerance in Candida albicans [PDF]

, 2013
Peer reviewedPublisher ...
Alix Therese Coste, B Enjalbert, B Enjalbert, B Wachtler, Bernhard Hube, C Fradin, C Onyewu, C Onyewu, D Harcus, Duncan Wilson, F Abe, F Ritossa, FL Mayer, François L. Mayer, G Kappe, H Senn, HJ Lo, ID Jacobsen, J Buchner, JA Lewis, K Richter, K Zakikhany, L Whitesell, LE Cowen, LE Cowen, LE Cowen, LE Cowen, LE Cowen, M Lis, M Ramsdale, M Taipale, M Taipale, MA Pfaller, MA Pfaller, MC Cruz, MC Lorenz, MS Fu, N Booth, N Robbins, P Uppuluri, RK Swoboda, RS Shapiro, RS Shapiro, RS Shapiro, RS Shapiro, S Diezmann, S Hodgetts, S Lindquist, S Nicholls, S Thewes, SD Singh, SL LaFayette, WJ Steinbach   +52 more
core   +2 more sources

Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

Molecules and Cells, 2016
Yingying Pu, Zhilun Zhao, Yingxing Li, Jin Zou, Qi Ma, Yanna Zhao, Yuehua Ke, Yun Zhu, Huiyi Chen, Matthew A. B. Baker, Hao Ge, Yujie Sun, X. Sunney Xie, Fan Bai   +13 more
openalex   +2 more sources

Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy [PDF]

, 2013
Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer ...
Chan, Kiat-Hwa, Gopalan, Began, Hauser, Charlotte A. E., Joshi, Mangesh, Lakshmanan, Anupama, Lam, Dang Hoang, Mishra, Archana, Reithofer, Michael R., Wang, Shu   +8 more
core   +1 more source

Image-based dynamic phenotyping reveals genetic determinants of filamentation-mediated beta-lactam tolerance [PDF]

, 2020
Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Camacho, Rafael, Fauvart, Maarten, Franke, Sabine, Hofkens, Johan, Marchal, Kathleen, Michielsen, Jan, Weytjens, Bram, Wilmaerts, Dorien, Zahir, Taiyeb   +8 more
core   +2 more sources

Prolactin [PDF]

, 1977
During an oral glucose tolerance test (OGTT) glucose and insulin levels were measured in 26 patients with prolactin-producing pituitary tumours without growth hormone excess.
A. Renauld, A. Weissmann, A.C. Herrington, A.J. Lostroh, B. Winkler, C.N. Hales, E. Cerasi, E.E. McGarry, F.H. Schmidt, I.B. Rathgeb, J. Tourniaire, J.D. Manns, K. von Werder, K. Werder von, K. Werder von, M. M. C. Landgraf-Leurs, M.O. Thorner, M.W. Sinkoff, P. Berle, P. C. Scriba, R. Hörl, R. Landgraf, R. Landgraf, R.C. Bodo De, Y.N. Sinha   +24 more
core   +1 more source

A straightforward meta-analysis approach for oncology phase I dose-finding studies [PDF]

Statistics in Medicine, 41(20):3915-3940, 2022, 2021
Phase I early-phase clinical studies aim at investigating the safety and the underlying dose-toxicity relationship of a drug or combination. While little may still be known about the compound's properties, it is crucial to consider quantitative information available from any studies that may have been conducted previously on the same drug.
arxiv   +1 more source

Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

Nature Communications, 2020
The determination of individual cell trajectories through a high-dimensional cell-state space is an outstanding challenge for understanding biological changes ranging from cellular differentiation to epigenetic responses of diseased cells upon drugging ...
Yapeng Su, Melissa E. Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica K. Wang, Jihoon W. Lee, Luke S. Frankiw, A. Xu, Stephanie W. Y. Wong, L. Robert, Kaitlyn Takata, D. Yuan, Yue Lu, Sui Huang, A. Ribas, R. Levine, G. Nolan, Wei Wei, S. Plevritis, Guideng Li, D. Baltimore, J. Heath   +22 more
semanticscholar   +1 more source