Results 51 to 60 of about 4,947,330 (332)

Induction of Aspergillus fumigatus zinc cluster transcription factor OdrA/Mdu2 provides combined cellular responses for oxidative stress protection and multiple antifungal drug resistance

mBio, 2023
Zinc cluster transcription factors (Zcfs) encoding zcf genes are exclusive for fungi and required for multiple cellular processes including metabolism and development.
Christoph Sasse, Emmanouil Bastakis, Fruzsina Bakti, Annalena M. Höfer, Isabella Zangl, Christoph Schüller, Anna M. Köhler, Jennifer Gerke, Sven Krappmann, Florian Finkernagel, Rebekka Harting, Joseph Strauss, Kai Heimel, Gerhard H. Braus   +13 more
doaj   +1 more source

Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis

eLife, 2017
Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams.
Saurabh Mishra, Prashant Shukla, Ashima Bhaskar, Kushi Anand, Priyanka Baloni, Rajiv Kumar Jha, Abhilash Mohan, Raju S Rajmani, Valakunja Nagaraja, Nagasuma Chandra, Amit Singh   +10 more
doaj   +1 more source

Drug Dependence: Drug Addiction, Drug Abuse, Drug Tolerance and Dependence

International Journal of Advanced Research in Science, Communication and Technology, 2023
Dependence means that when a person stops using a drug, their body goes through “withdrawal”: a group of physical and mental symptoms that can range from mild (if the drug is caffeine) to life-threatening (such as alcohol or opioids, including heroin and prescription pain relievers).
null Mrudula Shrikrishna Pachpande, null Nandini Bhushan Patil   +1 more
openaire   +1 more source

Drug-Induced Epigenetic Changes Produce Drug Tolerance

PLoS Biology, 2007
Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important role in these neural adaptations.
Wang, Yan, Krishnan, Harish R, Ghezzi, Alfredo, Yin, Jerry C. P, Atkinson, Nigel S.   +4 more
openaire   +5 more sources

Actionable mechanisms of drug tolerance and resistance in Mycobacterium tuberculosis

The FEBS Journal
The emergence of antimicrobial resistance (AMR) across bacterial pathogens presents a serious threat to global health. This threat is further exacerbated in tuberculosis (TB), mainly due to a protracted treatment regimen involving a combination of drugs.
Dipanwita Datta, Shaina Jamwal, Nishant Jyoti, Srinivas Patnaik, Dhiraj Kumar   +4 more
semanticscholar   +1 more source

Alteration of ribosome function upon 5-fluorouracil treatment favours cancer cell drug-tolerance

bioRxiv, 2020
Partial response to chemotherapy leads to disease resurgence. Upon treatment, a subpopulation of cancer cells, called drug-tolerant persistent cells, display a transitory drug tolerance that lead to treatment resistance 1,2.
Gabriel Thérizols, Zeina Bash-Imam, Baptiste Panthu, C. Machon, A. Vincent, J. Ripoll, Sophie Nait-Slimane, Mounira Chalabi-Dchar, Angéline Gaucherot, M. Garcia, Florian Laforêts, V. Marcel, J. Boubaker-Vitre, Marie Monet, C. Bouclier, C. Vanbelle, Guillaume Souahlia, E. Berthel, M. Albaret, H. Mertani, M. Prudhomme, M. Bertrand, A. David, J. Saurin, P. Bouvet, Eric Rivals, T. Ohlmann, J. Guitton, N. Dalla Venezia, J. Pannequin, Frédéric Catez, Jean-Jacques Diaz   +31 more
semanticscholar   +1 more source

Drug-Tolerant Idling Melanoma Cells Exhibit Theory-Predicted Metabolic Low-Low Phenotype

Frontiers in Oncology, 2020
Cancer cells adjust their metabolic profiles to evade treatment. Metabolic adaptation is complex and hence better understood by an integrated theoretical-experimental approach. Using a minimal kinetic model, we predicted a previously undescribed Low/Low (
Dongya Jia, B. Bishal Paudel, B. Bishal Paudel, B. Bishal Paudel, Corey E. Hayford, Corey E. Hayford, Corey E. Hayford, Keisha N. Hardeman, Keisha N. Hardeman, Herbert Levine, Herbert Levine, Herbert Levine, José N. Onuchic, José N. Onuchic, José N. Onuchic, José N. Onuchic, Vito Quaranta, Vito Quaranta   +17 more
doaj   +1 more source

Persister cells as a possible cause of antibiotic therapy failure in Helicobacter pylori

JGH Open, 2021
Background and Aim Due to the failure of antibiotic treatment and recurrence of infection in patients with Helicobacter pylori, this study was designed to find the possible cause of treatment failure and recurrence of the H.
Parvin Bahmaninejad, Sobhan Ghafourian, Mina Mahmoudi, Abbas Maleki, Nourkhoda Sadeghifard, Behzad Badakhsh   +5 more
doaj   +1 more source

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The ability of Mycobacterium tuberculosis to survive during prolonged treatment has been attributed to either transient stress responses or fixed heritable drug-resistance–producing mutations.
H. Safi, Pooja Gopal, Subramanya Lingaraju, Shuyi Ma, C. Levine, V. Dartois, Michelle Yee, Liping Li, L. Blanc, Hsin-Pin Ho Liang, Seema Husain, M. Hoque, P. Soteropoulos, T. Rustad, D. Sherman, T. Dick, D. Alland   +16 more
semanticscholar   +1 more source

Efficacy and tolerability of antiseizure drugs [PDF]

Therapeutic Advances in Neurological Disorders, 2021
Drug-resistant epilepsy occurs in 25–30% of patients. Furthermore, treatment with a first-generation antiseizure drug (ASD) fails in 30–40% of individuals because of their intolerable adverse effects. Over the past three decades, 20 newer- (second- and third-)generation ASDs with unique mechanisms of action and pharmacokinetic profiles have been ...
openaire   +3 more sources