The prospects of Monte Carlo antibody loop modelling on a fault-tolerant quantum computer [PDF]
Frontiers in Drug Discovery, 08 July 2022, 2021 Quantum computing for the biological sciences is an area of rapidly growing interest, but specific industrial applications remain elusive. Quantum Markov chain Monte Carlo has been proposed as a method for accelerating a broad class of computational problems, including problems of pharmaceutical interest.
arxiv +1 more source
SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children [PDF]
, 2018 Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs).
Arasi, Stefania +19 more
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Frontiers in Pharmacology, 2022 The latest consensus has changed CYP2D6 genotyping among Chinese population, while its impact on metoprolol tolerance and adverse events in elderly Chinese patients with cardiovascular diseases remains unclear.
Jianqiao Chen +14 more
doaj +1 more source
Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by Sirt1 to promote ethanol tolerance. [PDF]
, 2018 Drug naïve animals given a single dose of ethanol show changed responses to subsequent doses, including the development of ethanol tolerance and ethanol preference. These simple forms of behavioral plasticity are due in part to changes in gene expression
Adhikari, P +3 more
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Drug-Tolerant Idling Melanoma Cells Exhibit Theory-Predicted Metabolic Low-Low Phenotype
Frontiers in Oncology, 2020 Cancer cells adjust their metabolic profiles to evade treatment. Metabolic adaptation is complex and hence better understood by an integrated theoretical-experimental approach. Using a minimal kinetic model, we predicted a previously undescribed Low/Low (
Dongya Jia +17 more
doaj +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Objective To summarize the dynamic changes of cerebrospinal fluid (CSF) cytology in drug resistant tuberculous meningitis (TBM), and to explore its value in drug resistance and efficacy evaluation of TBM.
CAO Dong⁃dong +10 more
doaj +1 more source
Ethanol reversal of tolerance to the respiratory depressant effects of morphine [PDF]
, 2015 Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different ...
A Fugelstad +62 more
core +3 more sources
Antipsychotic-induced sensitization and tolerance: Behavioral characteristics, developmental impacts, and neurobiological mechanisms [PDF]
, 2016 Antipsychotic sensitization and tolerance refer to the increased and decreased drug effects due to past drug use, respectively. Both effects reflect the long-term impacts of antipsychotic treatment on the brain and result from the brain’s adaptive ...
Li, Ming
core +4 more sources
mSystems, 2023 Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of tuberculosis (TB) treatment and the emergence of drug-resistant strains. M.
Alisha M. Block +6 more
doaj +1 more source
Anthelmintic tolerance in free-living and facultative parasitic isolates of Halicephalobus (Panagrolaimidae) [PDF]
, 2012 Studies on anthelmintic resistance in equine parasites do not include facultative parasites. Halicephalobus gingivalis is a free-living bacteriovorous nematode and a known facultative parasite of horses with a strong indication of some form of tolerance ...
Andrássy +18 more
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