Results 51 to 60 of about 4,232,654 (389)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

A Sociological Approach to Drug Use

open access: yesEIRP Proceedings, 2021
Lately, the illicit drug market in Romania has shown a continuous dynamics, registering an increase both in the availability of most types of drugs consumed and in the total amount of drugs confiscated, especially cocaine and cannabis. The availability
Angela-Mihaela Ene
doaj  

Theoretical and practical aspects of preventive work in the fight against drug addiction

open access: yesВестник Тамбовского университета. Серия: Гуманитарные науки, 2020
The aim of the work is to study the theoretical and practical aspects of the emergence of drug addiction, types of preventive work in the fight against drug addiction, the peculiarities of its spread among adolescents. An assessment of the development of
Y. V. Platonova   +3 more
doaj   +1 more source

Incarcerating at Any Cost: Drug Trafficking and Imprisonment in Brazilian Court Reasoning

open access: yesJournal of Illicit Economies and Development, 2019
Brazil has the third largest prison population worldwide—over 700,000 people. At least 28% of them are in prison for drug trafficking. Given that situation, this paper explores the conflicts among the law; the Supremo Tribunal Federal, or Brazilian ...
M. Machado   +3 more
semanticscholar   +1 more source

The Courier Conundrum: The High Costs of Prosecuting Low-Level Drug Couriers and What We Can Do About Them [PDF]

open access: yes, 2019
Since the United States declared its “War on Drugs,” federal enforcement of drug-trafficking crimes has led to increased incarceration and longer prison sentences.
Weber, Adam B.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

The Drug-Trafficking Economy and Its Dynamics in Latin America

open access: yesÍconos, 2013
This article analyzes the behavior of drug-trafficking economy in Latin America during the last twelve years and its influence in the configuration of a new crime scenario in the region.
Daniel Pontón C.
doaj   +1 more source

Unemployment and Drug Trafficking Among Suspects in Custody of the National Drug Law Enforcement Agency, Cross River State Command, Nigeria

open access: yesEuropean Scientific Journal, 2019
The objective of this study is to determine the relationship between unemployment and drug trafficking in Nigeria with particular reference to suspects in custody of the National Drug Law Enforcement Agency (NDLEA), Cross River State Command.
Emmanuel Adeniyi, R. Eneji, J. T. Okpa
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Home - About - Disclaimer - Privacy