Results 91 to 100 of about 2,255,889 (297)

Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency

Frontiers in Pharmacology
IntroductionThe liver plays a critical role in drug pharmacokinetics. In in vivo experiments, it is difficult to isolate the liver’s contribution to drug systemic concentrations from that of the intestine and kidneys.
Vincent Rönnpagel, Felix Morof, Giuliano Ciarimboli, Markus Grube, Marleen J. Meyer-Tönnies, Mladen V. Tzvetkov   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Causes and Consequences of Variability in Drug Transporter Activity in Pediatric Drug Therapy.

, 2016
Drug transporters play a key role in mediating the uptake of endo-and exogenous substances into cells as well as their efflux. Therefore, variability in drug transporter activity can influence pharmaco- and toxicokinetics and be a determinant of drug ...
Gotta, V, van den Anker, Johannes N, Gotta, Verena, Rodieux, Frédérique, van den Anker, John, Pfister, Marc, Rodieux, F, Pfister, M, van den Anker, Johannes N., Gotta V, van den Anker JN, Pfister M, Rodieux F   +12 more
core   +1 more source

Clinical Studies on Drug-Drug Interactions Involving Metabolism and Transport : Methodology, Pitfalls, and Interpretation [PDF]

, 2019
Many drug-drug interactions (DDIs) are based on alterations of the plasma concentrations of a victim drug due to another drug causing inhibition and/or induction of the metabolism or transporter-mediated disposition of the victim drug. In the worst case,
Tornio, Aleksi, Mikko Niemi, Niemi, Mikko, Filppula, Anne M., Aleksi Tornio, Janne T. Backman, Anne M. Filppula, Backman, Janne T.   +7 more
core   +1 more source

Drug Transporters [PDF]

, 2006
Contributors. Preface. 1 Overview of Drug Transporter Families (Guofeng You and Marilyn E. Morris). 2 Organic Cation Transporters (Thomas J. Urban and Kathleen M. Giacomini). 3 Organic Cation/Carnitine Transporters (Ijaz A. Qureshi, Ihsan Elimrani, Ernest Seidman, and Grant Mitchell). 4 Organic Anion Transporters (Megha Nagle, David M.
openaire   +1 more source

OATP1A2 mediates Aβ1-42 transport and may be a novel target for the treatment of Alzheimer’s disease

Frontiers in Pharmacology
Alzheimer’s disease (AD) is a neurodegenerative disease with an unknown cause. Many studies have suggested that the imbalance between the clearance and accumulation of β-amyloid protein (Aβ) in the brain of AD patients is the main cause of AD development
Jinhua Wen, Menghua Zhao, Yuwei Xiao, Sihong Li, Weiqiang Hu   +4 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Transporter protein and drug resistance of Trypanosoma [PDF]

, 2016
Trypanosoma infection is one of the most important infections in livestock and humans. One of the main problems of its therapeutic control and treatment is the resurgence of drug resistance.
Medina, N.P., Mingala, C.N.
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source