Results 71 to 80 of about 2,255,889 (297)

Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers

Drug Design, Development and Therapy, 2017
Tae-Eun Kim,1 Na Ha,2 Yunjeong Kim,2 Hyunsook Kim,1 Jae Wook Lee,3 Ji-Young Jeon,2 Min-Gul Kim2,4 1Department of Clinical Pharmacology, Konkuk University Medical Center, Seoul, 2Center for Clinical Pharmacology, Biomedical Research Institute, Chonbuk ...
Kim TE, Ha N, Kim Y, Kim H, Lee JW, Jeon JY, Kim MG   +6 more
doaj  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Transporter-mediated natural product–drug interactions for the treatment of cardiovascular diseases

, 2017
The growing use of natural products in cardiovascular (CV) patients has been greatly raising the concerns about potential natural product–CV drug interactions.
Weibin Zha, Zha, Weibin, Zha, W.
core   +1 more source

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Beuers, Ulrich, Lehmann, Frank, Terracciano, Luigi, Hruz, Petr, Zimmermann, Christian, Gutmann, Heike, Drewe, Juergen, Beglinger, Christoph, Zimmermann C, Gutmann H, Hruz P, Beuers U, Lehmann F, Terracciano L, Drewe J, Beglinger C   +15 more
core   +1 more source

Transporters involved in hepatobiliary transport of drugs.

Folia Pharmacologica Japonica, 2010
近年，ヒト肝臓において非常に多くのトランスポーターが同定・機能解析されるにつれて，トランスポーターの遺伝子多型や薬物間相互作用による機能変動が薬物動態に与える影響を明らかにするための臨床研究も続々と報告されてきている．それに伴い，異物解毒システムの中でのトランスポーターの重要性が広く認知されてきた．代謝によって消失すると考えられてきた薬物の中にも肝取り込みトランスポーターの基質が含まれていることが明らかとなり，取り込みトランスポーターの機能変動が薬物動態の変化につながる事例が複数報告されてきている．本稿では，ヒト肝臓に発現する主な薬物トランスポーターを紹介すると共に，これらの遺伝子多型・薬物間相互作用が薬物動態や薬効・副作用に与える影響について概説することを目指した．
openaire   +3 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

The NorM MATE transporter from N. gonorrhoeae: insights into drug and ion Binding from atomistic molecular dynamics simulations

, 2014
The multidrug and toxic compound extrusion transporters extrude a wide variety of substrates out of both mammalian and bacterial cells via the electrochemical gradient of protons and cations across the membrane.
Khalid, Syma, Syma Khalid, Leung, Yuk Ming, Yuk Ming Leung, Holdbrook, Daniel A., Thomas J. Piggot, Piggot, Thomas J., Daniel A. Holdbrook   +7 more
core   +1 more source

The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development [PDF]

, 2018
The past few years have ushered in a wealth of new information on transporter biology, ranging from the publication of new crystal structures of the human glucose transporters (SLC2A2)1 to the discovery of the mechanism by which the monocarboxylate ...
Kathleen M. Giacomini, Galetin, Aleksandra, Shiew Mei Huang, Giacomini, Kathleen M., Aleksandra Galetin, Huang, Shiew Mei   +5 more
core   +1 more source

Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation

Nature Communications
Multidrug transport by ATP binding cassette (ABC) exporters entails a mechanism to modulate drug affinity across the transport cycle. Here, we combine cryo-EM and molecular dynamics (MD) simulations to illuminate a lipid-competition mechanism to drive ...
Qingyu Tang, Matt Sinclair, Paola Bisignano, Yunsen Zhang, Emad Tajkhorshid, Hassane S. Mchaourab   +5 more
doaj   +1 more source