Results 71 to 80 of about 251,779 (303)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea

, 2009
The grey mould fungus Botrytis cinerea causes losses of commercially important fruits, vegetables and ornamentals worldwide. Fungicide treatments are effective for disease control, but bear the risk of resistance development.
Pradier Jean-Marc, Pradier, J.M., Walker, Anne-Sophie, Mernke, Dennis, Pradier, Jean Marc, J. M., Leroux, Pierre, Matthias Hahn, Matthias Kretschmer, Sabine Fillinger, Walker, Anne Sophie, Kretschmer, M., Hahn, Matthias, Fillinger Sabine, Jean-Marc Pradier, Mosbach, Andreas, Walker, A.S., Mernke, Denis, Kretschmer Matthias, Mernke, D., Fillinger, S., de Waard, Maarten A, Maarten A De Waard, Walker, Anne Sophie, A. S., Leroux, P., de Waard, M.A., De Waard Maarten A., Leroux Pierre, Fillinger-David, Sabine, Helma, S. H., Anne-Sophie Walker, Pierre Leroux, Waard, Maarten A. De, Schoonbeek, Henk-jan, Leroch, Michaela, Leroch, M., Pradier, Jean Marc, Leroux, Pierre, P., Mosbach, A., Waard, M.A., de, Dennis Mernke, Pradier, Jean-Marc, Hahn Matthias, Leroch Michaela, Walker Anne-Sophie, Schoonbeek Henk-Jan, Fillinger-David, Sabine, Helma, Henk-Jan Schoonbeek, Mernke Dennis, Fillinger, Sabine, Mosbach Andreas, Andreas Mosbach, Michaela Leroch, Kretschmer, Matthias, Schoonbeek, H.J., Hahn, M.   +53 more
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Binding of Small Molecule Drugs to Porcine Vitreous Humor [PDF]

, 2018
Pharmacokinetics in the posterior eye segment has therapeutic implications due to the importance of retinal diseases in ophthalmology. In principle, drug binding to the components of the vitreous, such as proteins, collagen, or glycosaminoglycans, could ...
Anna-Kaisa Rimpelä, Arto Urtti, Saku Reunanen, Hagström, Marja, Rimpelä, Anna-Kaisa, Kidron, Heidi, Urtti, Arto, Heidi Kidron, Marja Hagström, Reunanen, Saku   +9 more
core   +1 more source

Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers

Drug Design, Development and Therapy, 2017
Tae-Eun Kim,1 Na Ha,2 Yunjeong Kim,2 Hyunsook Kim,1 Jae Wook Lee,3 Ji-Young Jeon,2 Min-Gul Kim2,4 1Department of Clinical Pharmacology, Konkuk University Medical Center, Seoul, 2Center for Clinical Pharmacology, Biomedical Research Institute, Chonbuk ...
Kim TE, Ha N, Kim Y, Kim H, Lee JW, Jeon JY, Kim MG   +6 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

SLC2A9 is a high-capacity urate transporter in humans [PDF]

, 2008
Background Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have
Doblado M, Kumari, Meena, Charchar, Fadi J, Samani, NJ, Elliott Paul, Kooner J, M. Marmot (7611368), Eyheramendy S, Dobson Richard J, Marmot, Michael, Connell, JM, Philip Howard, Caulfield, Mark J., J. Chambers (3846385), Connell John M, Munroe, Patricia B, John Chambers, Marmot Michael, Dobson, RJ, Charchar Fadi J, Doblado, M, Kumari, M, Morris Brown, Dobson RJ, Elliott, Paul, Gudrun Veldre, R. J. Dobson (7602557), Caulfield MJ, Iacone, Roberto, Laan, Maris, Lathrop, G. Mark, A. Dominiczak (7611551), Kooner, Jaspal, P. Strazzullo (7611365), Farrall Martin, Viigimaa Margus, Brown, M, Samani, Nilesh J., Francesco P Cappuccio, Lann, Maris, P. Howard (7611350), Nilesh J. Samani (7579793), Farrall, M, K. H. Moley (7611569), Newhouse, Stephen J, Munroe PB, Veldre, Gudrun, Wallace Chris, Evans, S, Chambers, John, Howard P, Martin Farrall, Deb O'Neill, Witkowska K, Newhouse, SJ, M. Laan (7602659), Maris Laan, Charchar FJ, Munroe Patricia B, M. Viigimaa (7602620), Cheeseman C., Dominiczak A, M. Doblado (7611566), Evans Sarah, Onipinla A, Shaw-Hawkins Sue, Lathrop GM, Evans, Sarah, Iacone Roberto, Marmot, M, C. Wallace (7602467), Munroe, PB, Witkowska, K, Wallace, C, M. Farrall (6522599), Moley, KH, Charchar, Fadi J., Brunner E, Eric Brunner, Chris Wallace, Brunner Eric, G. M. Lathrop (7611353), O'Neill, D, Dobson, Richard J., G Mark Lathrop, Richard J Dobson, F. J. Charchar (7591784), Howard Philip, Cappuccio FP, Cappuccio, Francesco, Evans S, E. Brunner (7611371), Lathrop, GM, S. Shaw-Hawkins (7602380), Org Elin, Chambers John, Moley, Kelle Harbert, F. P. Cappuccio (7611356), Wallace, Chris, Connell, J. M. C., Cheeseman, Chris, Sue Shaw-Hawkins, Stephen J Newhouse, Dobson, Richard, Samani NJ, Kelle H Moley, Patricia B Munroe, Howard, P, Wallace C, Cappuccio Francesco P, Veldre Gudrun, Caulfield Mark J, Manuel Doblado, Moley Kelle H, Elin Org, Viigimaa, M, S. J. Newhouse (7602371), Onipinla, Abiodun, Michael Marmot, Elliot, Paul, Dominiczak, A, Veldre G, R. Iacone (7611362), Abiodun Onipinla, Mark J Caulfield, Sarah Evans, Marmot M, Cheeseman Chris, Kooner, J, Brown Morris, J. Kooner (7609340), Laan, M, Moley, Kelle H, Witkowska Kate, Moley, Kelle H., C. Ji (7611359), Shaw Hawkins, Sue, Kumari Meena, P. B. Munroe (7602386), Veldre, G, Farrall, Martin, Pasquale Strazzullo, Laan M, D. O'Neill (7611560), Brown, M. J. (Morris Jonathan), Shaw-Hawkins, Sue, Chris Cheeseman, Samani, Nilesh J, Strazzullo, P, Dobson, Richard; id_orcid, Cappuccio, Francesco P., K. Witkowska (7611563), Munroe, Patricia B., Cappucio, Francesco P., Charchar, FJ, Brunner, Eric, Newhouse SJ, Witkowska, Kate, Kate Witkowska, O'Neill, Deb, Moley KH, Elliott, P, Org, E, Lathrop G. Mark, Paul Elliott, E. Org (7602644), O'Neill Deb, Doblado Manuel, Caulfield, Mark, Marmot, Michael G., John M Connell, Onipinla Abiodun, Caulfield, MJ, Org E, J. M. Connell (7602551), Cappuccio, FP, Newhouse, Stephen, Onipinla, A, Susana Eyheramendy, Newhouse, Stephen J., Brown, Morris, Jaspal Kooner, S. Eyheramendy (7611197), Roberto Iacone, Samani Nilesh J, Fadi J Charchar, Shaw Hawkins S, Strazullo, Pasquale, Cheeseman, C, Elliott P, Strazzullo Pasquale, M. Brown (3020991), Ji Chen, Cheeseman, Chris (Christopher I.), Meena Kumari, Chambers, John, MD, Org, Elin, Anna Dominiczak, S. Evans (6370628), Dominiczak Anna, Iacone, R, Dobson, Richard J, Brunner, E, Margus Viigimaa, P. Elliott (1293702), Viigimaa, Margus, Chen Ji, Connell, John M., Farrall M, Eyheramendy, S, M. J. Caulfield (7602383), Connell, John M, O'Neill D, Eyheramendy, Susana, Chambers J, C. Cheeseman (7611572), Laan Maris, Newhouse Stephen J, Caulfield, Mark J, Ji, C, Doblado, Manuel, Shaw-Hawkins, S, Dominiczak, A. F., Ji C, G. Veldre (7602656), Lathrop, G Mark, Eyheramendy Susana, A. Onipinla (7602377), Cappuccio, Francesco P, M. Kumari (7602503), Kooner Jaspal, Dominiczak, Anna, Nilesh J Samani, Brown M, Chambers, J, Viigimaa M, Strazzullo, Pasquale, Connell JM, Howard, Philip, Ji, Chen, Kumari M   +240 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation

Nature Communications
Multidrug transport by ATP binding cassette (ABC) exporters entails a mechanism to modulate drug affinity across the transport cycle. Here, we combine cryo-EM and molecular dynamics (MD) simulations to illuminate a lipid-competition mechanism to drive ...
Qingyu Tang, Matt Sinclair, Paola Bisignano, Yunsen Zhang, Emad Tajkhorshid, Hassane S. Mchaourab   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A molecular mechanism for eflornithine resistance in African trypanosomes [PDF]

, 2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei.
Creek Darren, Watson David G., Burchmore, Richard J S, Barrett, M.P., Michael P. Barrett, Woods, DJ, Pui Ee Wong, Vincent, I.M., Darren Creek, Vincent, IM, Kamleh, M.A., Richard J S Burchmore, Wong, P.E., Kamleh, Mohammed A, Woods, Debra J, Creek, Darren, Richard J. S. Burchmore, Wong, PE, Vincent, Isabel M, Isabel M Vincent, Michael P Barrett, Isabel M. Vincent, Kamleh, MA, Watson, DG, Woods, D.J., Wong, Pui Ee, Woods Debra J., Mohammed A. Kamleh, David G. Watson, Barrett, Michael P, Creek, D., Barrett Michael P., Barrett, MP, Burchmore, R.J.S., Wong Pui Ee, David G Watson, Kamleh Mohammed A., Vincent Isabel M., Watson, David G, Burchmore, RJS, Creek, D, Watson, D.G., Debra J Woods, Debra J. Woods, Mohammed A Kamleh, Burchmore Richard J. S.   +45 more
core   +1 more source