Results 81 to 90 of about 2,255,889 (297)

Gellan Gum Promotes the Differentiation of Enterocytes from Human Induced Pluripotent Stem Cells

Pharmaceutics, 2020
The evaluation of drug pharmacokinetics in the small intestine is critical for developing orally administered drugs. Caucasian colon adenocarcinoma (Caco-2) cells are employed to evaluate drug absorption in preclinical trials of drug development. However,
Shimeng Qiu, Tomoki Kabeya, Isamu Ogawa, Shiho Anno, Hisato Hayashi, Tatsuro Kanaki, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
Kabbara, S, Baune, B., Wang, T., Xu, X., McCarthy, P., Jaehne, E., Saleh, E., McClure, B., Woodcock, J., Wiszniak, S., Saleh, E, Schwarz, Q, McClure, B, Woodcock, J, McCarthy, P, Greenberg, Z, Kabbara, S., Wiszniak, S, Xu, X, Jaehne, EJ, van den Buuse, M., Wang, TY, Ramshaw, H., Schwarz, Q., Ramshaw, H, Lopez, A., Lopez, A, Baune, BT, Greenberg, Z., Parish, C., Van Den Buuse, M, Parish, C   +31 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Inhibitory Effect of AB-PINACA, Indazole Carboxamide Synthetic Cannabinoid, on Human Major Drug-Metabolizing Enzymes and Transporters

Pharmaceutics, 2020
Indazole carboxamide synthetic cannabinoid, AB-PINACA, has been placed into Schedule I of the Controlled Substances Act by the US Drug Enforcement Administration since 2015.
Eun Jeong Park, Ria Park, Ji-Hyeon Jeon, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Im-Sook Song, Hye Suk Lee   +7 more
doaj   +1 more source

Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium [PDF]

, 2018
Drug transporters can govern the absorption, distribution, metabolism, and excretion of substrate drugs and endogenous substances. Investigations to examine their potential impact to pharmacokinetic (PK) drug‐drug interactions (DDIs) are an integral part
Yuichi Sugiyama, Zur, Arik A., Kathleen M. Giacomini, Mingxiang Liao, Hanna, Imad, Giacomini, Kathleen M., Lei Zhang, Zamek-gliszczynski, Maciej J., Arik A. Zur, Lai, Yurong, Sugiyama, Yuichi, Maciej J. Zamek‐Gliszczynski, Yoshida, Kenta, Kusuhara, Hiroyuki, Yurong Lai, Vikram Arya, Hong Shen, Liao, Mingxiang, Shen, Hong, Zhang, Lei, Kenta Yoshida, Rodrigues, David, Hiroyuki Kusuhara, Xiaoyan Chu, Galetin, Aleksandra, Aleksandra Galetin, Imad Hanna, David Rodrigues, Arya, Vikram, Chu, Xiaoyan   +29 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Solid-state NMR investigations of the ATP binding cassette multidrug transporter LmrA [PDF]

, 2006
The development of resistance to multiple drugs is a major problem in treatment of number of infectious diseases and cancer. The phenomenon of multidrug resistance (MDR) is based on the synergetic interplay of a number of mechanisms such as target ...
Siarheyeva, Alena
core  

Drug-Transporter Gene and Refractory Epilepsy

, 2003
The drug-transporter gene ABCB1 polymorphism (C to T) at position 3435 was typed in 315 patients with epilepsy, classified as drug-resistant in 200 and drug-responsive in 115, and 200 controls without epilepsy, in a study at the Institute of Neurology ...
J Gordon Millichap, Millichap, J. Gordon
core   +1 more source