Results 81 to 90 of about 251,779 (303)

Gellan Gum Promotes the Differentiation of Enterocytes from Human Induced Pluripotent Stem Cells

Pharmaceutics, 2020
The evaluation of drug pharmacokinetics in the small intestine is critical for developing orally administered drugs. Caucasian colon adenocarcinoma (Caco-2) cells are employed to evaluate drug absorption in preclinical trials of drug development. However,
Shimeng Qiu, Tomoki Kabeya, Isamu Ogawa, Shiho Anno, Hisato Hayashi, Tatsuro Kanaki, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga   +8 more
doaj   +1 more source

Role of Hepatic Drug Transporters in Drug Development [PDF]

The Journal of Clinical Pharmacology, 2016
AbstractHepatic drug transporters can play an important role in pharmacokinetics and the disposition of therapeutic drugs and endogenous substances. Altered function of hepatic drug transporters due to drug‐drug interactions (DDIs), genetic polymorphisms, and disease states can often result in a change in systemic and/or tissue exposure and subsequent ...
Houfu, Liu, Jasminder, Sahi
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Pharmacokinetic aspects of retinal drug delivery [PDF]

, 2017
Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness.
Tiina Turunen, Arto Urtti, Bhattacharya, Madhushree, Kari, Otto K., Pelkonen, Laura, Richardson, Dominique, Elisa Toropainen, Madhushree Bhattacharya, Rimpelä, Anna-Kaisa Irmeli, Rimpelä, Anna Kaisa, Marco Casteleijn, Laura Pelkonen, Jaakko Itkonen, Schmitt, Mechthild, Urtti, Arto, Mika Reinisalo, Marika Ruponen, Lajunen, Tatu, Heidi Kidron, Antopolsky, Maxim, Toropainen, Elisa, Casteleijn, Marco; id_orcid, Heikkinen, Emma, Itkonen, Jaakko, del Amo, Eva M., Mechthild Schmitt, Reinisalo, Mika, Dominique Richardson, Emma Heikkinen, Otto K. Kari, Subrizi, Astrid, Anna-Kaisa Rimpelä, Vellonen, Kati Sisko, Casteleijn, Marco G., Kati-Sisko Vellonen, Tatu Lajunen, Turunen, Tiina, Kidron, Heidi, Astrid Subrizi, Eva M. del Amo, Eva Ramsay, Ruponen, Marika, Maxim Antopolsky, Ramsay, Eva, Vellonen, Kati-Sisko, Casteleijn, Marco   +45 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Beuers, Ulrich, Lehmann, Frank, Terracciano, Luigi, Hruz, Petr, Zimmermann, Christian, Gutmann, Heike, Drewe, Juergen, Beglinger, Christoph   +7 more
core   +1 more source

OATP1A2 mediates Aβ1-42 transport and may be a novel target for the treatment of Alzheimer’s disease

Frontiers in Pharmacology
Alzheimer’s disease (AD) is a neurodegenerative disease with an unknown cause. Many studies have suggested that the imbalance between the clearance and accumulation of β-amyloid protein (Aβ) in the brain of AD patients is the main cause of AD development
Jinhua Wen, Menghua Zhao, Yuwei Xiao, Sihong Li, Weiqiang Hu   +4 more
doaj   +1 more source

Inhibitory Effect of AB-PINACA, Indazole Carboxamide Synthetic Cannabinoid, on Human Major Drug-Metabolizing Enzymes and Transporters

Pharmaceutics, 2020
Indazole carboxamide synthetic cannabinoid, AB-PINACA, has been placed into Schedule I of the Controlled Substances Act by the US Drug Enforcement Administration since 2015.
Eun Jeong Park, Ria Park, Ji-Hyeon Jeon, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Im-Sook Song, Hye Suk Lee   +7 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine : Evaluation of Models for Ocular Drug Transport Study

The transcorneal route is the main entry route for drugs to the intraocular parts, after topical administration. The outer surface, the corneal epithelium (CE), forms the rate-limiting barrier for drug permeability. Information about the role and protein
Auriola, Seppo, Huttunen, Kristiina M., Montaser, Ahmed B., Urtti, Arto, Kidron, Heidi, Ramsay, Eva, Niitsu, Kanako, Terasaki, Tetsuya, Uchida, Yasuo   +8 more
core   +1 more source