Results 51 to 60 of about 2,255,889 (297)

Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. [PDF]

PLoS ONE, 2017
Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes. Limited data have additionally suggested that drug transporters, that constitute key-actors of
Lisa Chedik, Arnaud Bruyere, Marc Le Vee, Bruno Stieger, Claire Denizot, Yannick Parmentier, Sophie Potin, Olivier Fardel   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Sibley, CH, Malmberg, M, Nsobya, SL, Lebras, J, Nsanzabana, C, Faucher, JF, Thwing, J, Somé, AF, Ogutu, B, Houzé, S, Gadalla, NB, Björkman, A, Desai, M, Schramm, B, Venkatesan, M, Oguike, M, Ménard, D, Hamour, S, Plowe, CV, Dhorda, M, Djimdé, AA, Borrmann, S, Dorsey, G, Wong, RP, Fröberg, G, Stepniewska, K, Guérin, P, Kiechel, JR, Baliraine, FN, Johnson, J, Rombo, L, Kariuki, S, Ouédraogo, JB, Ademowo, G, Kofoed, PE, Grivoyannis, A, Falade, C, Sutherland, CJ, Nzila, A, Piola, P, Zongo, I, Eshetu, T, Dahal, P, Kamugisha, E, Ngasala, B, El-Sayed, BB, Rosenthal, PJ, Nosten, F, Eyase, F, Ursing, J, Otienoburu, SD, Davis, TM, Adam, I, Kironde, F, Zeynudin, A, Checchi, F, Moriera, C, Arze, C, Berens-Riha, N, Mwai, L, Price, RN, Faucher, Jean-François, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Berens-Riha, Nicole, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Kariuki, Simon, Mårtensson, Andreas,, Davis, Timothy, Gadalla, Nahla B, Ménard, Didier, Arze, Cesar, Djimdé, Abdoulaye A, Fröberg, Gabrielle, Ursing, Johan, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, Mwai, Leah, Kironde, Fred, Djimde, Abdoulaye, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Kofoed, Poul-Erik, Dahal, Prabin, Nzila, Alexis, Wong, Rina PM, Nsobya, Samuel L, Zongo, Issaka, Gadalla, Nahla, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Rombo, Lars, Kamugisha, Erasmus, Piola, Patrice, El-Sayed, Badria, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Grivoyannis, Anastasia, Malmberg, Maja, Hamour, Sally, Ogutu, Bernhards, Wong, Rina, Sibley, Carol Hopkins, Ngasala, Billy, Oguike, Mary, Venkatesan, Meera, Baliraine, Frederick N, LeBras, Jacques, El-Sayed, Badria B, Thwing, Julie, Price, Ric, Moriera, Clarissa, Kiechel, Jean-René, Nsanzabana, Christian, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Schramm, Birgit, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Mehul, Borrmann, Steffen, Nosten, Francois, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel, Martensson, A   +144 more
core   +2 more sources

Polymorphisms of SLCO1B1 Gene in Sundanese Ethnic Population of Tuberculosis Patients in Indonesia

Acta Medica Indonesiana, 2023
Background: The blood level of rifampicin, one of the tuberculosis (TB) drugs, depends on the organic anion transporting polypeptide 1B1 (OATP1B1) in hepatocytes. This protein is encoded by the solute carrier organic anion 1B1 (SLCO1B1) gene. Its genetic
Prayudi Santoso, Henny Juliastuti, Heda Melinda Nataprawira, Arto Yuwono Soeroto, Bachti Alisjahbana, Rovina Ruslami, Josephine Debora, Yunia Sribudiani, Ani Melani Maskoen   +8 more
doaj   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium

, 2022
Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or toxicity of many drugs. Numerous mechanisms (e.g., nuclear receptors, epigenetic gene regulation, microRNAs, alternative splicing, post‐translational modifications,
Brouwer, Kim L.R., Neuhoff, Sibylle, Hayden, Elizabeth, Micheline Piquette‐Miller, Piquette‐Miller, Micheline, Sprowl, Jason A., Piquette-Miller, Micheline, Noora Sjöstedt, Henriette E. Meyer zu Schwabedissen, Chitra Saran, Jason A. Sprowl, Raymond Evers, Li, Cindy Yanfei, Saran, Chitra, Elizabeth Hayden, Brouwer, Kim L. R., Shuiying Hu, Cindy Yanfei Li, Sibylle Neuhoff, Oswald, Stefan, Hu, Shuiying, Yue, Wei, Meyer zu Schwabedissen, Henriette E., Wei Yue, Sjöstedt, Noora, zu Schwabedissen, Henriette E. Meyer, Kim L.R. Brouwer, Simone H. Stahl, Evers, Raymond, Stahl, Simone H., Stefan Oswald   +30 more
core   +1 more source

A Bidirectional Permeability Assay for beyond Rule of 5 Compounds

Pharmaceutics, 2021
Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involved ...
Yunhai Cui, Cyril Desevaux, Ines Truebenbach, Peter Sieger, Klaus Klinder, Alan Long, Achim Sauer   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

"In silico" prediction of drug transport across physiological barriers [PDF]

, 2011
Physiological barriers maintain and safeguard homeostasis of certain body compartments by an increased resistance against free diffusion. Distribution and pharmacokinetics of drugs can be altered as well, if they have to cross these barriers in order to ...
Suenderhauf, Claudia
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source