Results 271 to 280 of about 251,779 (303)

Drug transporters and renal drug disposition in the newborn

The Journal of Maternal-Fetal & Neonatal Medicine, 2009
The individual response to a drug in terms of drug efficacy and toxicity is highly variable; this represents a major problem in clinical practice. Potential causes for such variability include pathogenesis and severity of the disease being treated, drug interactions, patient age, nutritional status, renal and liver function and concomitant illness ...
De Gregori S, De Gregori M, Borghesi A, Regazzi M, Stronati M., RANZANI, GUGLIELMINA   +5 more
openaire   +3 more sources

Drug transport and drug resistance in African trypanosomes

Drug Resistance Updates, 2003
Drug resistance in African trypanosomes has been studied for almost a hundred years. Beginning with Paul Ehrlich's work that led to the chemoreceptor hypothesis, reduction of net drug uptake has emerged as the most frequent cause of resistance. This review, therefore, focuses on trypanosomal drug transporter genes.
Mäser P, Lüscher A, Kaminsky R
openaire   +3 more sources

Importance of Drug Transporters in Pharmacokinetics and Drug Safety

Toxicology Mechanisms and Methods, 2008
ABSTRACT The exact role of transporters in the absorption, distribution, and excretion (ADE) of drugs is still being elucidated; however, current evidence suggests that their role in these processes may be significant. In this review, the role of transporters in the ADE, pharmacology, toxicology, and clinical drug-drug interactions (DDIs) of drugs will
openaire   +2 more sources

Drug Transporters Revisited

Journal of Clinical Psychopharmacology, 2001
L L, von Moltke, D J, Greenblatt
openaire   +2 more sources

Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates

Cell, 2021
Nan Wang, Xin Jiang, Shuo Zhang
exaly  

Transporter-Mediated Drug-Drug Interactions and Their Significance

2019
Drug transporters are considered to be determinants of drug disposition and effects/toxicities by affecting the absorption, distribution, and excretion of drugs. Drug transporters are generally divided into solute carrier (SLC) family and ATP binding cassette (ABC) family.
openaire   +2 more sources

Drug transport and transporters

2013
Roland J. Bainton, Evan D. Kharasch
openaire   +1 more source

Potential drug-drug interaction between sodium-glucose co-transporter 2 inhibitors and statins: pharmacological and clinical evidence

Expert Opinion on Drug Metabolism and Toxicology, 2021
Panagiotis-Nikolaos Lalagkas, Georgios Poulentzas, Christos Kontogiorgis   +2 more
exaly  

Drug Transporters

Current Protocols in Toxicology, 2012
Julio C. Davila, Jose E. Manautou
openaire   +1 more source

Transporter-mediated drug interactions: clinical implications andin vitroassessment

Expert Opinion on Drug Metabolism and Toxicology, 2007
Jiunn H Lin
exaly