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Drug Delivery and Drug Transport
2015Drug delivery is a key problem in the treatment of cancer. Most of the differences between tumor and host are quantitative, not qualitative. Therefore, untransformed cells have some sensitivity to many anti-cancer drugs. In particular, the conventional chemotherapy agents have high toxicity toward all proliferating cells, so it is essential that drug ...
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Drug transport and drug resistance in African trypanosomes
Drug Resistance Updates, 2003Drug resistance in African trypanosomes has been studied for almost a hundred years. Beginning with Paul Ehrlich's work that led to the chemoreceptor hypothesis, reduction of net drug uptake has emerged as the most frequent cause of resistance. This review, therefore, focuses on trypanosomal drug transporter genes.
Mäser P, Lüscher A, Kaminsky R
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Renal Drug Transport and Drug-Drug Interactions
Journal of Pharmacy Practice, 2002The kidney plays a vital role in the elimination of xenobiotics including drugs, toxins, and endogenous metabolites. Renal drug elimination involves 3 major processes: glomerular filtration, tubular secretion, and tubular reabsorption. Although glomerular filtration is a simple unidirectional diffusion process, renal tubular secretion and/or ...
Patrick T. Ronaldson, Reina Bendayan
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The impact of drug transporters on adverse drug reaction
European Journal of Drug Metabolism and Pharmacokinetics, 2013In this review, we have highlighted the adverse drug reaction mediated by transporters from two aspects: (1) competitive interactions between drug and drug/metabolite/endogenous substance mediated by transporters; (2) the expression/function change of transporter due to physiologic factors, disease, and drugs induction.
Yan, Zhou +8 more
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Drug transporters and renal drug disposition in the newborn
The Journal of Maternal-Fetal & Neonatal Medicine, 2009The individual response to a drug in terms of drug efficacy and toxicity is highly variable; this represents a major problem in clinical practice. Potential causes for such variability include pathogenesis and severity of the disease being treated, drug interactions, patient age, nutritional status, renal and liver function and concomitant illness ...
De Gregori S +5 more
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Journal of Clinical Psychopharmacology, 2001
L L, von Moltke, D J, Greenblatt
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L L, von Moltke, D J, Greenblatt
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Importance of Drug Transporters in Pharmacokinetics and Drug Safety
Toxicology Mechanisms and Methods, 2008ABSTRACT The exact role of transporters in the absorption, distribution, and excretion (ADE) of drugs is still being elucidated; however, current evidence suggests that their role in these processes may be significant. In this review, the role of transporters in the ADE, pharmacology, toxicology, and clinical drug-drug interactions (DDIs) of drugs will
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Transporter-Mediated Drug-Drug Interactions and Their Significance
2019Drug transporters are considered to be determinants of drug disposition and effects/toxicities by affecting the absorption, distribution, and excretion of drugs. Drug transporters are generally divided into solute carrier (SLC) family and ATP binding cassette (ABC) family.
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Antibody–Drug Conjugates: Smart Chemotherapy Delivery Across Tumor Histologies
Ca-A Cancer Journal for Clinicians, 2022Shanu Modi +2 more
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