Results 261 to 270 of about 396,504 (303)

Drug Transporters in Drug Efficacy and Toxicity

Annual Review of Pharmacology and Toxicology, 2012
Drug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or environmental factors such as dietary ...
M K, DeGorter, C Q, Xia, J J, Yang, R B, Kim   +3 more
openaire   +2 more sources

Transporter-mediated Drug Interactions

Drug Metabolism and Pharmacokinetics, 2002
Since 1994, researchers have isolated various genes encoding transporter proteins involved in drug uptake into and efflux from tissues that play key roles in the absorption, distribution and secretion of drugs in animals and humans. The pharmacokinetic characteristics of drugs that are substrates for these transporters are expected to be influenced by ...
openaire   +2 more sources

Enzymes, Drugs and Transport Phenomena

Protoplasma, 1967
Other contributors to this Symposium on Biophysics and Physiology of Biological Transport have dealt with the physicochemical aspects of membrane transport, what the membranes of cells and their organelles look like, how they behave physiologically, and the biochemical interpretation of the transport of isodium and potassium across such structures ...
K H, Beyer, J E, Baer
openaire   +2 more sources

Cellular Transport of Drugs

Clinical Infectious Diseases, 1994
The ability of drugs to enter cells and to reach an adequate concentration within the appropriate intracellular compartment may be an important determinant of the efficacy of therapy for infections due to intracellular pathogens. Antibiotics vary considerably in their ability to accumulate within cells.
openaire   +2 more sources

Transport of Drugs across Membranes

Protoplasma, 1967
In contrast to many compounds of physiological significance the penetration of drugs through membranes is, in general, passive, by diffusion or filtration. Most drugs are weak organic acids or bases, which in the unionized state are lipid soluble, but are hydrophilic when dissociated.
openaire   +2 more sources

Drug Transport Into Milk

2001
The advantages of breast-feeding for both mother (maternal-infant bonding, cost savings, reduced risk of premenopausal breast cancer, etc.) and for the infant (bactericidal effects of lysozyme, presence of immunoglobulins, more readily digested, decrease in food allergy, lower incidence of obesity and morbidity, etc.) are compelling and ensure the ...
openaire   +2 more sources

Drug Transporters Revisited

Journal of Clinical Psychopharmacology, 2001
L L, von Moltke, D J, Greenblatt
openaire   +2 more sources

Transport of Drugs

1992
The blood-brain barrier (BBB) at cerebral capillaries consists of a continuous layer of endothelial cells connected by tight junctions (zonulae occludens). The capillary wall lacks water-filled channels of suitable size for aqueous diffusion (except for water itself), and the endothelial cell membranes lack carrier systems of suitable affinity for ...
P. J. Robinson, S. I. Rapoport
openaire   +1 more source

Drug Delivery and Drug Transport

2015
Drug delivery is a key problem in the treatment of cancer. Most of the differences between tumor and host are quantitative, not qualitative. Therefore, untransformed cells have some sensitivity to many anti-cancer drugs. In particular, the conventional chemotherapy agents have high toxicity toward all proliferating cells, so it is essential that drug ...
openaire   +1 more source

Drug Transporters

Current Protocols in Toxicology, 2012
Julio C. Davila, Jose E. Manautou
openaire   +1 more source