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Advanced Healthcare Materials, EarlyView.Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo +6 more
wiley +1 more source
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Transporter-Mediated Drug–Drug Interactions
Pharmacogenomics, 2011Drug-drug interactions are a serious clinical issue. An important mechanism underlying drug-drug interactions is induction or inhibition of drug transporters that mediate the cellular uptake and efflux of xenobiotics. Especially drug transporters of the small intestine, liver and kidney are major determinants of the pharmacokinetic profile of drugs ...
Fabian, Müller, Martin F, Fromm
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Current Drug Metabolism, 2004
Any treatment of a pregnant woman with medication (drugs) de facto results in the treatment of her unborn child, even when her unborn child is not the target of drug therapy. This is because, in most instances, the placenta is not a complete barrier to the passage of drugs from the maternal to the fetal compartment.
Jashvant D, Unadkat +2 more
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Any treatment of a pregnant woman with medication (drugs) de facto results in the treatment of her unborn child, even when her unborn child is not the target of drug therapy. This is because, in most instances, the placenta is not a complete barrier to the passage of drugs from the maternal to the fetal compartment.
Jashvant D, Unadkat +2 more
openaire +2 more sources
Renal Drug Transporters and Drug Interactions
Clinical Pharmacokinetics, 2017Transporters in proximal renal tubules contribute to the disposition of numerous drugs. Furthermore, the molecular mechanisms of tubular secretion have been progressively elucidated during the past decades. Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular cells, and multidrug ...
Anton, Ivanyuk +3 more
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Membrane transporters play a central role in protecting the body from xenobiotics (either by preventing their absorption, limiting their distribution, or promoting their elimination). Transporters can also participate in trafficking and compartmentalization of physiological compounds.
Talevi, Alan, Bellera, Carolina Leticia
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Talevi, Alan, Bellera, Carolina Leticia
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Sonicated transdermal drug transport
Journal of Controlled Release, 2002The following review explores the promise shown by sonicated transdermal drug transport as a novel drug delivery system in great detail. It elucidates the advantages of transdermal drug transport (TDT) over the currently prevalent modes of drug administration and then goes on to explain why despite these obvious advantages TDT is so sparingly used ...
Amit, Joshi, Jaideep, Raje
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2002
A wide variety of transporters are found in the intestine, and are involved in the membrane transport of daily nutrients as well as drugs. These intestinal transporters are located in the brush border membrane as well as basolateral membrane. Each transporter exhibits its own substrate specificity, and some have broader specificities than others.
D M, Oh, H K, Han, G L, Amidon
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A wide variety of transporters are found in the intestine, and are involved in the membrane transport of daily nutrients as well as drugs. These intestinal transporters are located in the brush border membrane as well as basolateral membrane. Each transporter exhibits its own substrate specificity, and some have broader specificities than others.
D M, Oh, H K, Han, G L, Amidon
openaire +2 more sources
Pharmacogenetics of Drug Transporters
Current Pharmaceutical Design, 2010During the last decade, a greater focus has been given to impact of genetic variation in membrane transporters on the pharmacokinetics and toxicity of numerous therapeutic drugs. While the majority of transporter-related pharmacogenetic research has been in regards to classic genes encoding the outward-directed ATP-binding cassette (ABC) transporters ...
R M, Franke, E R, Gardner, A, Sparreboom
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Renal Drug Transport and Drug-Drug Interactions
Journal of Pharmacy Practice, 2002The kidney plays a vital role in the elimination of xenobiotics including drugs, toxins, and endogenous metabolites. Renal drug elimination involves 3 major processes: glomerular filtration, tubular secretion, and tubular reabsorption. Although glomerular filtration is a simple unidirectional diffusion process, renal tubular secretion and/or ...
Patrick T. Ronaldson, Reina Bendayan
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