Results 91 to 100 of about 8,164,322 (359)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Drug utilization study in patients with type 2 diabetes mellitus attending diabetes clinic of a tertiary care hospital in rural Bengal

, 2016
Background: Diabetes mellitus (DM) is a common and important health problem affecting the citizens of developed as well as developing nations. Not only does it require long term therapy, it is also crippling in terms of cost of management.
Sekhar Mandal, Tamoghna Maiti, A. Das, Abhijit Das, Ananya Mandal, B. Sarkar, Soumitra Mandal   +6 more
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Systematic review of drug utilization studies & the use of the drug classification system in the WHO-SEARO Region

The Indian journal of medical research, 2015
Background & objectives: Information available on drug consumption is inadequate in most low and middle income countries. This systematic review was conducted to analyse published work on drug utilization research/studies (DUR) in the SEARO region of WHO
Sagar S Bachhav, N. Kshirsagar
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Utilization of Parenteral Morphine by Application of ATC/DDD Methodology: Retrospective Study in the Referral Teaching Hospital

Frontiers in Public Health, 2017
BackgroundFew studies analyzed the pattern of opioid analgesic utilization in hospital settings. The aim of this study was to determine the consumption pattern of parenteral morphine in patients hospitalized in the Serbian referral teaching hospital and ...
Viktorija Dragojevic-Simic, Nemanja Rancic, Dusica Stamenkovic, Radoje Simic   +3 more
doaj   +1 more source

Evaluation of Drug Utilization and Analysis of Anti- Epileptic Drugs at Tertiary Care Teaching Hospital

, 2016
Background: Epilepsy has been considered as a public health problem by WHO and ILAE. It was felt that there remains considerable scope for the development of better epilepsy services in a developing country like India.
Jincymol George, J. Jose, D. Kulkarni, Ramesh R. Pol, Mallappa Shalavadi, C. Mangannavar   +5 more
semanticscholar   +1 more source

Pro-Arrhythmic Potential of Oral Antihistamines (H1): Combining Adverse Event Reports with Drug Utilization Data across Europe

PLoS ONE, 2015
Background There is appreciable utilisation of antihistamines (H1) in European countries, either prescribed by physician and purchased by patients for self-medication.
E. Poluzzi, E. Raschi, B. Godman, A. Koci, U. Moretti, Marija Kalaba, B. Wettermark, M. Sturkenboom, F. De Ponti   +8 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Non-adherence to antidementia medications and associated factors: a study of Spanish population-based registry data

Frontiers in Pharmacology
IntroductionWith an increasing prevalence, dementia is one of the most disabling diseases among the elderly. Impaired cognitive function and behavioral and psychological symptoms predispose patients to medication non-adherence, resulting in increased ...
Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón, M. Aránzazu Pedrosa-Naudín, Diego Fernández-Lázaro, Diego Fernández-Lázaro, Isabel Díaz Planelles, F. Javier Álvarez, F. Javier Álvarez   +9 more
doaj   +1 more source