Results 91 to 100 of about 280,718 (307)
Strategic Under-utilization of Patents and Entry Deterrence: The Case of Pharmaceutical Industry [PDF]
This paper seeks to explain why some pharmaceutical companies are observed to withdraw their products before patents are expired and simultaneously introduce new patented (competing) products.
Dutta, Arijita +2 more
core +1 more source
Advanced Science, EarlyView.Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao +12 more
wiley +1 more source
Advanced Science, EarlyView.Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza +9 more
wiley +1 more source
In Vitro Oral Cavity Permeability Assessment to Enable Simulation of Drug Absorption
PharmaceuticsBackground/Objectives: The oral cavity represents a convenient route of administration for drugs that exhibit significant hepatic first-pass extraction. In this study, the mucosal permeation properties of selected active pharmaceutical ingredients (APIs)
Pankaj Dwivedi +7 more
doaj +1 more source
The impact of the reference price system on the pharmaceutical market: A theoretical approach [PDF]
This article analyses the impact of the reference price system on the price-setting strategies of the pharmaceutical firms and on the level of generic usage.
Anna Merino
core
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Effects of 'Authorized-Generics' on Canadian Drug Prices [PDF]
This paper examines how the use of ‘authorized-generics’ (AGs) influences Canadian prescription drug prices. An authorized-generic is the actual brand name drug product, manufactured by the brand firm, but sold as a generic by a licensee or subsidiary of
Paul Grootendorst
core
Uji Disolusi dan Penetapan Kadar Tablet Loratadin Inovator dan Generik Bermerek [PDF]
, 2010 Antihistamines Loratadin available in tablet form, as loratadin tablets innovator, branded generic preparations. Socializing generic drugs need information about quality of these drugs, to ensure that the quality of generic drugs not lower or similar to ...
Lastari, P. (Pudji) +2 more
core
Osteoporosis: New-Generation Drugs [PDF]
Breast Care, 2010 A new understanding in the pathophysiology of bone led to the development of a fully human monoclonal antibody directed against RANK ligand (RANKL). Denosumab inhibits the interaction of RANKL with its receptor RANK, thereby suppressing osteoclast differentiation, function and survival.
openaire +2 more sources
Advanced Science, EarlyView.Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng +11 more
wiley +1 more source