Results 81 to 90 of about 81,901 (217)

Prescription of Generic Drugs

National Journal of Physiology, Pharmacy and Pharmacology, 2013
Healthcare cost is one of the major obstacles for healthcare providers. One of the major components of this increased cost of healthcare related expenses is cost of Medicines. Medicines consume major chunk of total money spent on healthcare.
Mayur Chaudhari, Jaykaran Charan
doaj   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Neurotoxicological Evaluation of Intrathecal Citrate Excipients: Calcium Homeostasis Disruption and Safety Implications in CNS Drug Delivery

Pharmaceutics
Background/Objectives: Intrathecal drug delivery is essential for treating CNS disorders, but the safety of commonly used excipients such as citric acid/sodium citrate (SC) remains unclear.
Jue Wang, Yuan Zhang, Qing He, Ying Du, Xia Zhang, Xinru Tan, Xinting Zhou, Susu Tang, Baoming Ning, Rui Yang, Xia Zhao, Dejiang Tan, Huimin Sun, Jiasheng Tu   +13 more
doaj   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Mastering particle size analysis: lessons, challenges, and future directions from the FDA–CRCG workshop

AAPS Open
Particle-size distribution (PSD) measurement is a cornerstone of pharmaceutical development and regulatory assessment, influencing formulation stability, dissolution, product quality, and performance.
Xiaoming Xu, William C. Smith, James E. Polli, Christine L. Plavchak, Bin Qin, Yan Wang, Nicholas Holtgrewe, Sam G. Raney, Andre O’Reilly Beringhs, Yihua Bruce Yu, Marc Taraban, Vishalakshi Krishnan, Anna Schwendeman, Dana C. Hammell, Jeffrey D. Clogston, Alan F. Rawle, Jernej Grmaš, Yousif Ayoub, Bernard Domnic, Rama Subba Reddy, Joseph Duncan, Matthew McGann, Jeff Bodycomb, Carl C. L. Schuurmans, Michiel Hermes, Jonathan G. Mehtala, Prashun Roy, Kevin Lance, Collin Britten, Kiwan Park, Daniel Beach, Matthew Elmer, Keith B. Rodenhausen, Zhen Xu, Haiou Qu, Kai-Wei Wu, Maxwell Korang-Yeboah, Yuan Zou, Ji Li, Alaa H. Abuznait, Colette Quinn, Anabelle Ethier, Kendice Ip, Dinesh Dhamecha, Qi Li, Dongkai Zhu, Rutu Valapil   +46 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population‐Based Study and Gut Microbiota Analysis

Advanced Science, EarlyView.
Frequent sweetened beverage consumption is associated with accelerated biological aging in a large Chinese population. Five gut microbial genera are consistently enriched in both frequent sweetened beverage consumers and individuals with accelerated aging and show significant mediating effects, suggesting a potential microbiota‐related pathway linking ...
Yuwei Shi, Xinmei Li, Yufan Hao, Qiaoyu Wu, Yuji Yu, Siyu Li, Nuo Xu, Yi‐Hsuan Wu, Eunhye Lee, Chi Chang, Emily Hu, Ying Lu, Elizabeth Delzell, Ann W. Hsing, Shankuan Zhu   +14 more
wiley   +1 more source

Development and comparison of model‐integrated evidence approaches for bioequivalence studies with pharmacokinetic end points

CPT: Pharmacometrics & Systems Pharmacology
By applying nonlinear mixed‐effect (NLME) models, model‐integrated evidence (MIE) approaches are able to analyze bioequivalence (BE) data with pharmacokinetic end points that have sparse sampling, which is problematic for non‐compartmental analysis (NCA).
Xiaomei Chen, Henrik B. Nyberg, Mark Donnelly, Liang Zhao, Lanyan Fang, Mats O. Karlsson, Andrew C. Hooker   +6 more
doaj   +1 more source

A Novel Lactose/MCC/L-HPC Triple-Based Co-Processed Excipients with Improved Tableting Performance Designed for Metoclopramide Orally Disintegrating Tablets

Pharmaceutics
New co-processed excipients comprising lactose (filler and sweetener), microcrystalline cellulose (MCC, filler), and low-substituted hydroxypropyl cellulose (L-HPC, disintegrant and binder) were developed via solvent evaporation for the preparation of ...
Xiaorong Dai, Jiamin Wang, Bo Yan, Qian Wang, Yan Shen, Yongkang Chen, Yu Tian   +6 more
doaj   +1 more source